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Background: Betulinic acid (BetA) exhibits a good pro-osteogenic differentiation effect on human periodontal ligament stem cells (hPDLSCs), making it a promising supplement for periodontal regeneration. Circular RNAs (circRNAs) have emerged as important regulators of cellular behaviour, and whether circRNAs are involved in the effects of BetA remains unknown.

Methods: Bioinformatics analysis was used to screen for dysregulated circRNAs involved in osteogenic differentiation based on public datasets.

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