Exploring the ventricular morphology of the heart of Brycon amazonicus (Agassiz, 1829) (Teleostei, Characiformes).

Brycon amazonicus, a fish species widely distributed along freshwater rivers in Latin America, is important in maintaining ecological balance. Although some morphological/physiological aspects of B. amazonicus have been reported, the cardiac histomorphology of this species remains poorly understood.

Casting Skin Dressing Containing Extractions of the Organic Part of Marine Sponges for Wound Healing.

Skin wounds are extremely frequent injuries related to many etiologies. They are a burden on healthcare systems worldwide. Skin dressings are the most popular therapy, and collagen is the most commonly used biomaterial, although new sources of collagen have been studied, especially spongin-like from marine sponges (SPG), as a promising source due to a similar composition to vertebrates and the ability to function as a cell-matrix adhesion framework.

Exploring transparency: A comparative analysis of explainable artificial intelligence techniques in retinography images to support the diagnosis of glaucoma.

Machine learning models are widely applied across diverse fields, including nearly all segments of human activity. In healthcare, artificial intelligence techniques have revolutionized disease diagnosis, particularly in image classification. Although these models have achieved significant results, their lack of explainability has limited widespread adoption in clinical practice.

Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein.

Virus-like particles (VLPs) are an established vaccine platform and can be strong immunogens capable of eliciting both humoral and cellular immune responses against a range of pathogens. Here, we show by cryo-electron microscopy that VLPs of Mayaro virus, which contain envelope glycoproteins E1-E2 and capsid, exhibit an architecture that closely resembles native virus. In contrast to monomeric and soluble envelope 2 (E2) glycoprotein, both VLPs as well as the adenovirus and modified vaccinia virus Ankara (MVA) vaccine platforms expressing the equivalent envelope glycoproteins E1-E2, and capsid induced highly neutralising antibodies after immunisation.

Personalized nutrition and precision medicine in perimenopausal women: A minireview of genetic polymorphisms COMT, FUT2, and MTHFR.

This mini-review explores the potential of precision medicine and personalized nutrition in addressing health challenges faced by perimenopausal women, focusing on the role of genetic polymorphisms in key metabolic pathways. Specifically focus on the single nucleotide polymorphisms (SNPs) in the COMT, FUT2, and MTHFR genes, which influence neurotransmitter metabolism, gut microbiota composition, and folate homeostasis, respectively. These polymorphisms are critical in modulating hormonal fluctuations, metabolic imbalances, and nutrient absorption during perimenopause.

Renal Function Markers Predicts Extubation Failure in Critically Ill Patients: A Retrospective Study.

Several studies attempt to identify predictors for weaning and extubation from mechanical ventilation (MV) and none have been shown to be particularly accurate. Therefore, the objective of the study was to evaluate whether markers of renal function may be associated with extubation failure. This retrospective study collected data through electronic medical records for 2 consecutive years.

Bioactive glasses for bone tissue engineering: a bibliometric study of the top 100-most cited papers.

Using bioactive glasses (BGs) for bone reconstruction is a promising and expanding field of investigation in regenerative medicine. Therefore, the aim of this study was to assess the key features of the 100 most cited papers on BG in bone tissue engineering through bibliometric measures. A search was conducted in the Web of Science citation indexing database until October 2023.

The effect of breakfast skipping and sleep disorders on glycemic control, cardiovascular risk, and weight loss in type 2 diabetes.

Background & Aims: Meal timing is an emerging branch of science that investigates the influence of eating patterns on the circadian rhythm and overall health. There are still discrepancies in the literature as to whether late distribution of food intake and sleep disorders could impact biochemical, anthropometric, and cardiovascular markers. The objectives of this study were firstly observe skipping breakfast and sleep disorders over 12 months.

Understanding and evaluating risk perception, knowledge, and food safety self-reported practices of public-school students in Brazil.

Foodborne diseases are a global burden. Actions to fight this group of diseases are necessary, especially for the younger demographic, which consists of consumers, food handlers, and the future workforce of the food chain. To this end, outlining the food safety profile of the target audience is imperative.

Sclareolide as Antifungal Strategy Against : Unveiling Its Mechanisms of Action.

Cryptococcal infection commonly begins as an opportunistic infection in humans, however, this can escalate to a systemic or life-threatening form in immunocompromised individuals. Here, we aim to identify novel antifungal molecules from plants resources. Sclareolide, a phytochemical classified as a sesquiterpene lactone, was assessed against H99.

Long-Term Physical Activity Mitigates Inflammaging Progression in Older Adults Amidst the COVID-19 Pandemic.

Background: Inflammaging and physical performance were investigated in older adults before and after the COVID-19 pandemic.

Methods: Older women ( = 18) and men ( = 7) (mean age = 73.8 ± 7.

Correction: Lana et al. Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord Injuries. 2024, , 461.

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Validation of Clinical Protocol of Astigmatism Induction in Pseudophakic Patients.

Purpose: Validate a novel approach for assessing residual astigmatism's impact on visual acuity in pseudophakic patients using defocus curves and spherical equivalent compensation.

Materials And Methods: Thirteen patients over 40 with cataracts and normal ophthalmological examinations were enrolled in a prospective, non-randomized cohort study. The defocus curve method was employed, wherein visual acuity was measured with spherical lenses ranging from -2.

Mindfulness and trial-based cognitive therapy for the psychological well-being in the judiciary: A controlled and randomized study protocol.

Introduction: The judiciary sector faces high absenteeism due to mental health issues, yet applying effective therapies like mindfulness and trial-based cognitive therapy (TBCT) remains unexplored.

Objectives: Develop and apply Mindfulness-Integrated Trial-Based Cognitive Therapy (M-TBCT) in the judiciary to assess its acceptability, feasibility, and efficacy in enhancing psychological well-being and reducing depression, anxiety, and improving self-care.

Methods: Conduct a controlled, randomized study in two phases: Phase 1 involves a pilot study to structure the M-TBCT protocol and test its acceptability and feasibility in the judiciary ( = 30); Phase 2, an efficacy trial with 90 participants, comparing M-TBCT to a waitlist.

Morphodynamics drive the transport and accumulation of anthropogenic microparticles in tropical coastal depositional systems in southeastern Brazil.

A significant limitation in current coastal pollution research is that microplastics (<5 mm) comprise only a fraction of all anthropogenic microparticles (AMP, <5 mm) scale residues. Comprehensive AMP assessments, including those comprising semisynthetic, and modified natural compositions, are lacking. For instance, the accumulation of AMP in different coastal morphological features within a depositional system remains poorly known, fueling long-lasting debates about the distribution process of microparticles.

The Emergence of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Piauí, Brazil.

Introduction: In Brazil, the emergence of feline sporotrichosis, a neglected subcutaneous mycosis primarily transmitted by cats and caused by the fungus Sporothrix brasiliensis, has been monitored via molecular tools. This approach underscores the geographic expansion of this disease and highlights the critical role of molecular surveillance in understanding its epidemiology and guiding public health interventions.

Methods: We investigated three domestic cats (Felis catus) with multiple skin lesions in Picos, Piauí, Brazil.

Infection and pulmonary vascular diseases consortium: United against a global health challenge.

Leveraging the potential of virtual platforms in the post-COVID-19 era, the Infection and Pulmonary Vascular Diseases Consortium (iPVDc), with the support of the Pulmonary Vascular Research Institute (PVRI), launched a globally accessible educational program to highlight top-notch research on inflammation and infectious diseases affecting the lung vasculature. This innovative virtual series has already successfully brought together distinguished investigators across five continents - Asia, Europe, South and North America, and Africa. Moreover, these open global forums have contributed to a comprehensive understanding of the complex interplay among immunology, inflammation, infection, and cardiopulmonary health, especially concerning pulmonary hypertension and related pulmonary disorders.

Optimizing Surgical Outcomes: A Case Series on BREAST-V for Treating Breast Asymmetries.

Background: Breast asymmetry occurs when there is a discrepancy in the shape, volume, or positioning of the breasts. Various factors, including unequal development of breast buds, endocrine disorders, chest wall deformities, and surgical or posttraumatic sequelae, can contribute to this condition. Although breast asymmetry is common, clinically severe cases are rare and often require surgical correction because of potential postural, aesthetic, and psychological issues.

Toward New Therapeutics for Visceral Leishmaniasis: Efficacy and Mechanism of Action of Amides Inspired by Gibbilimbol B.

The problems with current strategies to control canine visceral Leishmaniasis (CVL), which include the euthanasia of infected animals, and also the toxicity of the drugs currently used in human treatments for CVL, add urgency to the search for new therapeutic agents. This study aimed to evaluate the activity against of 12 amides that are chemically inspired by gibbilimbol B, a bioactive natural product that was initially obtained from . Three of these compounds--(2-ethylhexyl)-4-chlorobenzamide (), -(2-ethylhexyl)-4-nitrobenzamide (), and -(2-ethylhexyl)-4-(-butyl)benzamide () -demonstrated activity against the intracellular amastigotes without toxicity to mammalian host cells (CC > 200 μM); compounds , , and resulted in EC values of 12.

Enhancing Ex Vivo Limbal Epithelial Cell Expansion on Amniotic Membrane: A Comparative Study of Monolayer (2D) Versus Sandwich (3D) Culture Configurations.

Purpose: This study compared two-dimensional (monolayer) and three-dimensional (sandwich) systems for expanding ex vivo limbal epithelial cells on amniotic membrane and evaluated the outcomes after transplantation into rabbits with experimentally induced limbal stem cell deficiency.

Methods: Evaluations included markers for progenitor cells, proliferation, apoptosis, and clinical monitoring for up to 63 days. In the monolayer culture, epithelial cells derived from limbal explants were expanded on amniotic membrane as the substrate.

Keratoconus Detection in High-Astigmatism Pediatric Patients: Optimal Pentacam Indices and Cutoff Points.

Purpose: To assess the accuracy of various Pentacam indices in distinguishing keratoconus (KC) in pediatric patients with high astigmatism and to establish appropriate cutoff values.

Methods: This prospective multicenter cross-sectional study included 312 eyes from 167 patients aged 6 to 18 years (mean age, 13.1 ± 3.