Carboxysomes: The next frontier in biotechnology and sustainable solutions.

Some bacteria possess microcompartments that function as protein-based organelles. Bacterial microcompartments (BMCs) sequester enzymes to optimize metabolic reactions. Several BMCs have been characterized to date, including carboxysomes and metabolosomes.

GLP-1 RECEPTOR AGONISTS USE AND INCIDENCE OF GLAUCOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS: GLP-1 receptor agonists use and incidence of glaucoma.

Introduction: In diabetics, glucagon-like peptide 1 (GLP-1) receptor agonists (RA) may protect against microvascular alterations and oxidative stress, both of which have been implicated in glaucoma. Multiple studies suggest a possible relation between GLP-1 RA use and the development of glaucoma. This study performs a systematic review of the literature regarding the incidence of glaucoma development in type 2 diabetes patients treated with GLP-1 receptor agonists compared to a control group.

Adjuvant Immunotherapy in High-Risk Muscle-Invasive Urothelial Cancer: An Updated Meta-Analysis of Randomized Controlled Trials.

Introduction: Neoadjuvant cisplatin-based chemotherapy followed by radical surgery is the standard treatment for muscle-invasive urothelial carcinoma (MIUC). The Checkmate-274 and AMBASSADOR trials have demonstrated improvements in disease-free survival (DFS) with adjuvant immunotherapy. Consequently, this meta-analysis aimed to assess the effectiveness of strategies involving checkpoint inhibitors in managing high-risk MIUC.

A comprehensive methodology to assess human bone transversal toughness based on macroscopic specimens, the compliance method, and 3D bio-faithful numerical simulations.

This study proposes a method for assessing the transverse toughness of human long-bone cortical tissue. The method is based on a three-point bending test of pre-notched femur diaphysis segments, post-processed using the compliance method coupled with numerical simulations. Given the cracking nature of bone and if cracking processes remain confined to the crack tip, it is assumed that the compliance method can be used.

In the era of transition from fiction to reality: Robotic-assisted neurointervention-a systematic review and meta-analysis.

Objective: In recent years, the application of robotic assistance in diagnostic and therapeutic endovascular neurointerventional procedures has gained notable attention. In this systematic review and meta-analysis, we aim to evaluate the feasibility, safety, and current indications of robotic-assisted neurointerventions and to assess the degree of robotic assistance and reasons for unplanned manual conversion from robotic assistance.

Methods: We searched Medline, Scopus, Web of Science, and Cochrane Library databases following PRISMA guidelines and included studies with ≥ 4 patients reporting on robotic-assisted neurointerventions.

Cycling Isokinetic Peak Force Explains Maximal Aerobic Power and Physiological Thresholds but Not Cycling Economy in Trained Triathletes.

: Assessments of muscle strength help prescribe and monitor training loads in cyclists (e.g., triathletes).

Intra and Inter-Test Reliability of Isometric Hip Adduction Strength Test with Force Plates in Professional Soccer Players.

Assessing the reliability of measurement instruments and equipment is essential to ensure the accurate tracking of athletes over extended periods, minimizing the measurement errors caused by chance or other factors. However, a less common but equally important analysis is the verification of inter-measurement agreement, which complements the reliability results. To evaluate the intra- and inter-test reliability of an isometric hip adduction strength and asymmetries test in professional soccer players.

Awake Craniotomy for Eloquent Brain Arteriovenous Malformations: A Systematic Review and Individual Patient Data Meta-Analysis.

Background: Arteriovenous Malformations (AVMs) pose a risk of neurologic deterioration, particularly when located in eloquent areas. While awake surgery is well-established for treating low-grade gliomas near eloquent areas, its efficacy for AVMs is less conclusively reported.

Methods: This study conducted a systematic review and individual patient data (IPD) meta-analysis following Cochrane Collaboration and PRISMA guidelines.

Relationship between cardiorespiratory fitness and falls in older adults: A population-based study.

Aim: The present study investigated the relationship between cardiorespiratory fitness (CRF) and episodes and severity of falls in older adults.

Methods: This cross-sectional study drew on data from the Brazilian 2019 National Health Survey. The sample consisted of 18 991 older adults (aged ≥60 years).

Postmortem fingerprint identification: A novel adaptive approach to the transillumination technique using moistened black volcano powder for fragile epidermal tissue.

Postmortem identification through fingerprints often encounters significant challenges, particularly with damaged epidermal tissue, due to factors such as carbonization, putrefaction, mummification, or saponification. Traditional techniques frequently fall short in cases involving fragile skin, which complicates the collection of clear fingerprint impressions. This study presents and evaluates an adaptive modification of the transillumination technique, integrating it with moistened black volcano powder to enhance fingerprint recovery from compromised postmortem tissue.

Evaluating carbon removal: Integrating technical potential with environmental, social, governance criteria, and sequestration permanence.

Climate modeling suggests that achieving international climate goals requires a reduction in current CO emissions by over 90%, with any remaining emissions to be addressed through carbon dioxide removal (CDR) solutions. Sixteen CDR strategies are evaluated by integrating technical potential, environmental, social, and governance (ESG) criteria, along with sequestration permanence. This evaluation, conducted by ENGIE's scientific council using an interdisciplinary Delphi panel methodology, proposes a "quality" measure for each technology.

Mercury Levels in the Worldwide Farmed Fish: A Systematic Review.

Aquaculture, specifically farmed fish, contributes to global aquatic fish stuff production. The present study systematically reviewed mercury levels in farmed fish. One hundred two scientific articles were found in four databases.

Metabolic acidosis with elevated anion gap and euglycemic ketoacidosis in pregnant and postpartum women with severe Covid-19.

Background/objectives: Pregnant and postpartum women have a higher risk for developing severe Covid-19 and other clinical and obstetric complications. This study aims to evaluate the frequency of metabolic acidosis with elevated anion gap and describe a case series of euglycemic ketoacidosis (EKA) in pregnant and postpartum women with severe confirmed or suspected Covid-19.

Materials And Methods: Observational retrospective study carried in a reference intensive care unit from May 2020 to June 2022.

Congenital absence of the left atrial appendage: a positive coincidence for the electrophysiologist? A case report.

Background: The congenital absence of the left atrial appendage (LAA) is an extremely rare anatomical anomaly, with only 23 cases documented in medical literature. The LAA plays a critical role in thrombus formation, particularly in patients with atrial fibrillation (AF), thus impacting stroke prevention strategies and the management of anticoagulation.

Case Summary: We report a 48-year-old male with a 2-year history of hypertension and prior episodes of tachycardic palpitations, who presented with AF and chest pain.

Incidence of hepatobiliary malignancies in primary sclerosing cholangitis: systematic review and meta-analysis.

Background And Aims: Primary sclerosing cholangitis (PSC) is a known risk factor for hepatobiliary malignancies. We conducted a systematic review and meta-analysis of published studies to determine the incidence and risk factors for hepatobiliary malignancies in people with PSC.

Methods: Pubmed and Embase databases were searched from inception to April 10, 2024 for cohort studies reporting data on the incidence of cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), or gallbladder cancer (GBC) in PSC.

The Healthy Oral Microbiome: A Changing Ecosystem throughout the Human Lifespan.

Microorganisms have co-evolved with a variety of plants and animals, developing complex symbiotic relationships with their hosts and the environment. The diversity of symbionts acquired over time help their hosts to adapt, survive, and evolve more rapidly and efficiently, improving fitness across the lifespan. Understanding these synergistic relationships between humans and their endogenous microbiota may provide valuable information on human physiology and on potential mechanisms associated with the onset of diseases.

Platelet-Neutrophil aggregate formation induces NLRP3 inflammasome activation in VITT.

Background: Although rare, vaccine-induced thrombotic thrombocytopenia (VITT) following adenoviral vector COVID-19 vaccination is a concerning and often severe adverse effect of vaccination. The generation of high anti-platelet factor 4 (PF4) antibody titers, promotes the formation of immune complexes capable of activating platelets and neutrophils through FcγRIIa.

Objective: Given that Platelet-leukocyte aggregate (PLA) formation and inflammasome activation are common features of thromboinflammatory diseases, we aimed to evaluate if these are also features of VITT.

Palm and interesterified palm oil-enhanced brown fat whitening contributes to metabolic dysfunction in C57BL/6J mice.

Palm oil is widely used in the food industry owing to its high stability and versatility. The interesterified version has been used as an alternative to oils rich in trans fatty acids. However, the health effects of these vegetable oils are not yet fully understood.

The effects of exercise on anxiety and depression in adults with cancer: A meta-review of meta-analyses.

Background: This meta-review aimed to synthesize the evidence of the effects of exercise on anxiety and depression symptoms amongst adults with cancer, and cancer-survivors, comparing effects sizes between meta-analysis.

Methods: Major databases were searched up to February 9, 2024 for meta-analyses evaluating the effects of exercise, using anxiety and/or depression scales. Effect size (ES) values were calculated as standardized differences in the means and expressed as the Standardized Mean Difference (SMD) with the 95% confidence interval (95%CI).

Comparison between 2- and 4-plate fixation in Le Fort I osteotomy: a mixed methods systematic review.

Objective: Achieving postsurgical skeletal stability is crucial for successful outcomes and patient satisfaction. Precision maxillofacial surgery, which integrates precision techniques with minimally invasive approaches, is increasingly recognized for its potential to enhance long-term stability and reduce surgical risks and complications. This study aimed to comprehensively evaluate the impact of fixation techniques (2 vs 4 plates) during Le Fort I osteotomy in orthognathic surgery on skeletal stability.