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Study of the Gut Microbiome in Patients with Psoriatic Arthritis.
Eur J Rheumatol
September 2024
Division of Dermatology and Rheumatology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro Faculty of Medicine, Rio de Janeiro, Brazil.
Article Synopsis
- Gut dysbiosis is thought to be connected to immune-mediated diseases like psoriasis, with this study focusing on the gut microbiome in patients with severe psoriatic disease and those with psoriatic arthritis.
- The research utilized 16S rRNA gene sequencing to analyze stool samples from 30 patients, revealing significant differences in the gut microbiome composition, particularly an increase in the Bacteroides genus in those with psoriatic arthritis.
- Although the study highlights these microbiome differences, it notes limitations like the small patient group and ongoing questions about whether gut dysbiosis is a cause or effect of the disease, emphasizing the potential for future interventions.