The impact of resistance training in patients diagnosed with metabolic dysfunction-associated steatotic liver disease: a systematic review.

Resistance training, as a modality of physical exercise, has been recognized as a fundamental pillar in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Current reviews, however, have not given due priority to the specific effects of this type of training on hepatic and clinical markers in individuals with MASLD. This study aimed to compile the available evidence on the impact of resistance training on hepatic and clinical parameters in individuals diagnosed with MASLD.

Putative paraneoplastic alopecia in a cat with apocrine adenocarcinoma.

Feline paraneoplastic alopecia is associated with intraabdominal neoplasms. A 13-year-old female cat was presented with a history of a cutaneous mass on the head, followed by ventrally distributed alopecia with shiny skin. Necropsy revealed an apocrine adenocarcinoma and telogenisation/miniaturisation of the hair follicles, respectively.

Life cycle of Amblyomma calcaratum (Ixodida: Ixodidae) under laboratory conditions.

The life-cycle of Amblyomma calcaratum was evaluated experimentally under laboratory conditions using birds (Serinus canaria, Gallus gallus) and rodents (Calomys callosus) as hosts for immatures and a rabbit (Oryctolagus cuniculus) as host for adults. Developmental periods of the non-parasitic stages were observed in an incubator at 27 °C and 90% RH. The passerine S.

Sarcopenia and the biological determinants of aging: A narrative review from a geroscience perspective.

Background: The physiopathology of sarcopenia shares common biological cascades with the aging process, as does any other age-related condition. However, our understanding of the interconnected pathways between diagnosed sarcopenia and aging remains limited, lacking sufficient scientific evidence.

Methods: This narrative review aims to gather and describe the current evidence on the relationship between biological aging determinants, commonly referred to as the hallmarks of aging, and diagnosed sarcopenia in humans.

Power exercises with elastic bands combined with endurance training improve pulse pressure, systolic blood pressure, and functional parameters in older adults.

Objective: This study aimed to investigate the effects of power training (PT) using elastic bands combined with endurance training (ET) on pulse pressure (PP), systolic (SBP) and diastolic blood pressures (DBP), autonomic response (AR), and functional parameters in older adults.

Methods: Thirty participants were randomly assigned to the control group ( n = 15) and the intervention group (IG) ( n = 15). IG participants performed PT with elastic bands combined with ET twice weekly for 8 weeks.

Innovative Photoprotection Strategy: Development of 2-(Benzoxazol-2-Yl)[(2-Hydroxynaphthyl)Diazenyl] Phenol Derivatives for Comprehensive Absorption of UVB, UVA, and Blue Light.

Overexposure to blue light due to the excessive use of electronic devices has been implicated in premature skin aging and eye damage, among other injuries to health. This study aimed to synthesize two azo derivatives of the 2-(amino-2'-hydroxyphenyl) benzoxazole and explore their potential as UV and blue light filters, proposing a new spectral profile. The synthesis of the heterocyclic compounds involved condensation reactions and diazotation.

Advanced Oral Health Protection: A Multifunctional Dentifrice Designed to Prevent Oral Diseases and Conditions.

In 1948, the United Nations General Assembly in Paris declared that a standard of health was a universal human right.1 There is no reason to suggest that this affirmation should not include oral health as well. Oral health is a human right! Oral diseases are a public health problem that impair quality of life and generate increased costs and demands.

Sex-differences in neuromuscular control of hip abductors during isometric submaximal tasks.

Background: One key focus in the literature is the need to better understand how males and females perform neuromuscular control, which requires consideration of muscle morphology, as it may change neural drive during force production. Although previous studies focused on muscles around the knee and ankle, it is crucial to explore the behavior of other muscles, such as the hip abductors, since many lower limb conditions more common in females have been associated with alterations in hip muscles.

Research Questions: Are electromyography (EMG) variables (amplitude and low- and high frequency bands) of hip abductors during submaximal isometric tasks different between males and females? How is muscle size associated with EMG responses during these tasks?

Methods: Thirty-six participants (males, n = 18; females, n = 18) had muscle and subcutaneous thickness of gluteus medius (GMed) and tensor fascia latae (TFL) measured.

Cytotoxic properties of hydroalcoholic extract on androgen unresponsive prostate cancer cells.

Androgen independent phase in prostate cancer (PCa) commonly limits the therapeutic efficacy. through its main active compound, α-thujone, appears to be an option, considering its anti-proliferative, anti-metastatic and pro-apoptotic effects on hepatocellular carcinoma. However, studies on PCa are limited.

Clinical Staging of Alcohol Use Disorder: Proposal of a New Stratified Approach.

Introduction: Clinical staging is widely applied in various fields of Medicine. Staging makes it possible to constitute early diagnoses and interventions, improving prognosis and preventing disease progression. In relation to Alcohol Use Disorder (AUD), staging is still an underdeveloped subject in the scientific literature.

Improving triage performance in emergency departments using machine learning and natural language processing: a systematic review.

Background: In Emergency Departments (EDs), triage is crucial for determining patient severity and prioritizing care, typically using the Manchester Triage Scale (MTS). Traditional triage systems, reliant on human judgment, are prone to under-triage and over-triage, resulting in variability, bias, and incorrect patient classification. Studies suggest that Machine Learning (ML) and Natural Language Processing (NLP) could enhance triage accuracy and consistency.

White diet is not necessary during dental bleaching treatment: A systematic review and network meta-analysis of clinical studies.

Objectives: This systematic review with network meta-analysis (NMA) answered whether a white diet is necessary during dental bleaching and if there was any coloring food impacting more significantly the bleaching potential.

Data Sources: The review followed the PRISMA Extension Statement for NMA. Six electronic databases and gray literature were searched until April 2024.

Nanoencapsulation with Eudragit® and chia mucilage increases the stability and antifungal efficacy of carvacrol against spp.

Carvacrol is a consolidated natural antimicrobial. However, its use in food is a challenge due to characteristic odour and high volatility. Nanoencapsulation has emerged to overcome these drawbacks.

Glycolic acid and ultrasonic activation: Effects on smear layer removal, dentin penetration, dentin structure and bond strength of the root dentin filling material.

Background: Glycolic acid (GA) has been tested as enamel and dentin etchant, and final irrigant for smear layer removal. This study evaluated the effects of GA and ultrasonic activation (US) on smear layer removal, dentin penetration, dentin structure and bond strength of the root dentin filling material.

Material And Methods: The root canals of 210 teeth were distributed into four test groups: smear layer removal (N=50), dentin penetration (N=50), dentin structure (N=10) and bond strength (N=100).

Effects of nanocapsules containing lumefantrine and artemether in an experimental model of cerebral malaria.

Background: Malaria, a tropical neglected disease, imposes a significant burden on global health, leading to the loss of thousands of lives annually. Its gold standard treatment is a combination therapy of lumefantrine (LUM) and artemether (ART). Nanotechnology holds significant potential for improving drug bioavailability and potency while reducing adverse effects.

The transformative journey of community health workers in implementing a lifestyle intervention in Brazil: A qualitative study.

Introduction: Community health workers (CHWs) stand as critical frontline agents within the Brazilian healthcare system. In this qualitative study, we examined the impact of a community-based behavioral change intervention spearheaded by CHWs.

Methods: The intervention focused on promoting healthy behaviors - physical activity, nutrition, and emotional well-being - among individuals aged 50 and older living in a rural community in Brazil.

Lipid-core nanocapsules containing simvastatin do not affect the biochemical and hematological indicators of toxicity in rats.

Our research group previously studied the effectiveness of lipid-core nanocapsules (LNC) containing simvastatin (SV-LNC) in treating cognitive impairment in rats. While our results were promising, we needed to evaluate the potential toxicity of the nanoparticles themselves. This study aimed to compare the biochemical and hematological parameters of adult Wistar rats receiving LNC or SV-LNC to those receiving low doses of simvastatin crystals dispersed in a saline solution over 45 days.

Gender-dependent effect of physical activity on the risk of incident multimorbidity during the COVID-19 pandemic: Findings from the PAMPA cohort, Brazil.

Objectives: We aimed to investigate the association between physical activity (PA) and the risk of incident multimorbidity in adults from southern Brazil during the COVID-19 pandemic.

Study Design: Prospective Study.

Methods: We analyzed data from the Prospective Study about Physical and Mental Health (PAMPA) cohort, a longitudinal study of adults living in southern Brazil.

Rifaximin prophylaxis in MASLD‑hepatocellular carcinoma: Lessons from a negative animal model.

The incidence of hepatocellular carcinoma (HCC) has been rising, particularly among individuals diagnosed with metabolic dysfunction-associated steatotic liver disease. In the present study, the prophylactic effects of rifaximin (RIF) on HCC, inflammatory markers and cardiovascular risk (CVR) were investigated in an animal model. Adult Sprague-Dawley rats were randomly allocated into three groups (n=10, each): Control [standard diet/water plus gavage with vehicle (Veh)], HCC [high-fat choline deficient diet (HFCD)/diethylnitrosamine (DEN) in drinking water/Veh gavage] and RIF [HFCD/DEN/RIF (50 mg/kg/day) gavage] groups.

An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings.

Introduction: Interventions to treat speech-language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have received less attention.

Methods: Following Core Outcome Set Standards for Development Recommendations (COSSTAD), this study comprised: Stage 1 - systematic review to identify measures; Stage 2 - consensus groups to identify important outcome constructs for people with PPA (n = 82) and care partners (n = 91); Stage 3 - e-Delphi consensus with 57 researchers.

Leisure-time physical activity, cardiorespiratory fitness, and cognitive decline in middle-aged and older adults - The ELSA-Brasil study.

Objectives: Dementia is a fast-growing public health problem. This study examined the association of physical activity and estimated cardiorespiratory fitness (eCRF) with the risk of cognitive impairment.

Study Design: Multicentric, prospective cohort study.