High Expression of GABA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma.

Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABA) receptor, which is a ligand-gated ion channel. GABA receptor activation via GABA binding allows for an intracellular influx of Cl ions, thus inducing cellular hyperpolarization. Each GABA receptor consists of a combination of five subunits, and several subunits have been proposed as biomarkers and therapeutic targets in cancer.

Blockchain in Health Information Systems: A Systematic Review.

(1) Background: With the increasing digitalization of healthcare systems, data security and privacy have become crucial issues. In parallel, blockchain technology has gradually proven to be an innovative solution to address this challenge, as its ability to provide an immutable and secure record of transactions offers significant promise for healthcare information management. This systematic review aims to explore the applications of blockchain in health information systems, highlighting its advantages and challenges.

Physical Fitness, Executive Functions, and Academic Performance in Children and Youth: A Cross-Sectional Study.

The aim of this cross-sectional study was to investigate the relationship between physical fitness, executive function, and academic performance in children and adolescents. A total of 131 students (49% female) aged 10-15 years from a public school in Rio de Janeiro were assessed in executive functions (hearts and flowers, Corsi's block, and digit span tasks), academic performance (Portuguese, reading, math, and overall school grade), physical tests (touch test disc, agility, lower limb and upper limb explosive strength), and anthropometric measurements. Regression results showed that the composite of sports-related fitness measures was the best predictor of executive functions (β = 0.

Effects of multiple cold-water immersion during pre-season on recovery performance in under-20 male soccer players: A randomized controlled trial.

Introduction: This study was designed to evaluate the effects of multiple cold-water immersions performed daily during the preseason period on biochemical, clinical, and neuromuscular aspects of muscle damage of soccer players.

Methods: This two-arm, prospectively registered, randomized controlled trial, blinded to statistician and assessors, was conducted at professional football club facilities. Twenty-three under-20 semi-professionals male soccer players were randomly allocated into cold water immersion group (bathtub with water and ice at 10 °C ± 1 °C for 10 min) or control group (rest for 10 min), every day, after training sessions during a preseason.

Local, proximal, and distal effects of resistance training with blood flow restriction on strength and size of upper limb muscles in healthy individuals: A systematic review.

Introduction: Resistance training with blood flow restriction (BFR) can promote gains in muscle strength and size using low-load protocols.

Objective: To gather the evidence on local, proximal, and distal effects of resistance training with BFR on the strength and size of upper limb muscles in healthy individuals.

Methods: Searches were performed in CENTRAL, PEDro, MEDLINE, SciELO, SCOPUS, and Science Direct databases from inception to March 2023.

Enhancement of a Mathematical Model for Predicting Puberty Stage in Boys: A Cross-Sectional Study.

Background: Previously, we developed a mathematical model capable of predicting pubertal development (PD) through seven anthropometric variables, with an accuracy of 75%. We believe that it is possible to develop a similar model that uses fewer anthropometric measurements and provides greater precision.

Objective: Develop a mathematical model capable of predicting PD through anthropometric variables.

Synergistic effect of ozone treatment with α-amylase on the modification of microstructure and paste properties of japonica rice starch.

The objective was to evaluate the synergistic effect of ozonization and α-amylase on modifying the microstructure and paste properties of starch, using 0.00042 g of ozone/100 g of buffer for various durations. Enzymatic susceptibility was increased, achieving maximum values of 12.

Digital health and quality of care in Primary Health Care: an evaluation model.

Introduction: The implementation of technologies in Primary Health Care with monitoring and evaluation of the quality of health care is fundamental to direct the access and quality of health care in the context of the Sustainable Development Goals. Our objective was to develop a model for evaluating digital health interventions in primary care, considering its impact on first contact, longitudinality, integrality and coordination in health.

Methodology: This is an exploratory methodological study of a qualitative nature.

Functional near-infrared spectrometry for auditory speech stimuli in cochlear implant users: a systematic literature review.

Objective: This study aims to identify the acquisition features of functional near-infrared spectroscopy (fNIRS) in cochlear implant users.

Methods: A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE, LILACS, Web of Science, Scopus, PsycINFO, IEEE Xplore, Google Scholar, and ProQuest Dissertations & Theses Global were searched using the PECOS acronym.

SSVEP modulation via non-volitional neurofeedback: anproof of concept.

Neuronal oscillatory patterns are believed to underpin multiple cognitive mechanisms. Accordingly, compromised oscillatory dynamics were shown to be associated with neuropsychiatric conditions. Therefore, the possibility of modulating, or controlling, oscillatory components of brain activity as a therapeutic approach has emerged.

Artificial intelligence model for predicting sexual dimorphism through the hyoid bone in adult patients.

The objective of this study was to develop a predictive model using supervised machine learning to determine sex based on the dimensions of the hyoid bone. Lateral cephalometric radiographs of 495 patients were analyzed, collecting the horizontal and vertical dimensions of the hyoid bone, as well as the distance from the hyoid to the mandible. The following algorithms were trained: Logistic Regression, Gradient Boosting Classifier, K-Nearest Neighbors (KNN), Support Vector Machine (SVM), Multilayer Perceptron Classifier (MLP), Decision Tree, AdaBoost Classifier, and Random Forest Classifier.

Detecting a Stalker: The Effect of Body Posture, Gaze Direction, and Camouflage Pattern on Predator Detection.

The success of a predatory attack is related to how much a predator manages to approach a prey without being detected. Some carnivore mammals use environmental objects (e.g.

Phase angle as a marker of muscle quality: A systematic review and meta-analysis.

Background & Aims: Phase angle (PhA) is a biomarker derived from raw bioelectrical impedance analysis (BIA) values: resistance (R) and reactance (Xc). PhA reflects cellular membrane integrity and, as a result, has been considered a marker of fluid distribution, making it a potential prognostic indicator. A growing body of research demonstrates independent associations between PhA and muscle strength, mass, and composition.

Barriers and Facilitators Affecting Access to Health Care for People With Syphilis: Protocol for a Scoping Review.

Background: Syphilis is a systemic, preventable, and curable infection caused by the bacterium Treponema pallidum. Despite being treatable, syphilis continues to have a high incidence, with a resurgence observed even in countries with strong health surveillance systems. This highlights the need to understand the various strategies used globally to improve access to care for individuals with syphilis.

The effect of particle size on structural and catalysts for oxygen evolution reaction of (CoFeNiMnCr)O prepared by controlled synthesis with polyvinylpyrrolidone (PVP).

In this study, high-entropy spinel oxides (CoNiMnFeCr)O were synthesized using a PVP-assisted sol-gel method, marking the first report of this approach for producing high-entropy oxides. This method provides new insights into morphology customization through precise temperature control during calcination. Samples were calcined at 800, 900, and 1000 °C, and structural, optical, and electrochemical characterizations were performed to evaluate the impact of synthesis conditions on the oxygen evolution reaction (OER) performance.

Effect of nanoencapsulation on the solubility and antioxidant activity of astaxanthin pigmented oil extracted from shrimp waste (Litopeneaus vannamei).

Astaxanthin-pigmented oil from shrimp waste meal was nanoencapsulated by O/W emulsification using porcine gelatin (EAG) and a combination with soy protein (EAGS 2:2 and EAGS 3:1) to improve the solubility and antioxidant activity of the pigmented oil. The encapsulates presented spherical shape and smooth surface; particle size equal to 159.68 (14.

Cystic Lesions and Odontogenic Tumors in Older People: A Brazilian Multicenter Study.

Background: Some odontogenic cysts (OCs) and odontogenic tumors (OTs) are infiltrative and often recur, causing bone destruction and tooth loss. In the elderly, in particular, these injuries cause significant morbidity, making rehabilitation difficult and compromising the quality of life of these individuals. Objective: To determine the prevalence and demographic characteristics of OCs, non-odontogenic cysts (NOCs), and OTs diagnosed in an elderly Brazilian population (≥60 years).

Impact of conservative therapy on otologic signs and symptoms in patients with temporomandibular disorders: A systematic review and meta-analysis.

Objective: To evaluate the effect of conservative therapeutic interventions in adult patients with temporomandibular disorders (TMD) and associated otologic symptoms.

Methods: An electronic search across six databases and grey literature was conducted. Studies were assessed for risk of bias, a random-effects meta-analysis, and the certainty of the evidence was evaluated using the GRADE tool.

Proof of Concept for the Organic Electrorefinery Technology with Actual Effluents.

This work describes results of a first proof of the concept of electrorefinery with a real waste obtained from a cashew nut factory, and it shows the effect of the current densities of both the anodic oxidation and electrochemically assisted separation processes on the performance of the system. Results obtained demonstrate that electrorefinery is a promising option to minimize the carbon fingerprint, worth studying for increasing the sustainability of the environmental remediation of wastes, because valuable species can be obtained from the destruction of pollutants and recovered within the same integrated process. They also point out that there is still a long way to reach an optimum solution for this technology, but it is worth the effort to be made.

Empirical Testing of a Middle-Range Theory for Ineffective Breathing Pattern in Children With Congenital Heart Disease.

Aim: To test a middle-range theory (MRT) for the nursing diagnosis of ineffective breathing pattern in children with congenital heart disease (CHD) based on analysis of two general propositions.

Methods: This cross-sectional study is guided by STROBE. The propositions represent hypotheses about the relationships between the concepts of this MRT to be tested empirically, and thus, log-linear models were used to verify the structure of the proposition related to the stimuli.

Breathing Modulates Network Activity in Frontal Brain Regions during Anxiety.

Anxiety elicits various physiological responses, including changes in the respiratory rate and neuronal activity within specific brain regions such as the medial prefrontal cortex (mPFC). Previous research suggests that the olfactory bulb (OB) modulates the mPFC through respiration-coupled oscillations (RCOs), which have been linked to fear-related freezing behavior. Nevertheless, the impact of breathing on frontal brain networks during other negative emotional responses, such as anxiety-related states characterized by higher breathing rates, remains unclear.