Clinical Interplay Between Autism Spectrum Disorder and Bipolar Disorder: A Narrative Review.

Introduction: Autism Spectrum Disorder (ASD) and Bipolar Disorder (BD) present significant challenges in diagnosis due to their complex nature. This review aims to examine the interface and overlapping features of these conditions.

Methods: We conducted a narrative review to examine clinical overlap, common psychiatric comorbidities, and shared neurobiological bases between ASD and BD.

The Effects of Hydrological Disasters on the Population's Health in the Northeast Region of Brazil.

The Northeast region of Brazil is characterized by long periods of drought. However, the region is also frequently affected by floods. The socioeconomic characteristics of the locality make the population more vulnerable to the impacts of these disasters.

Predicting extubation failure in neonates: The role of lung ultrasound and corrected gestational age in safe weaning in the NICU.

Unlabelled: To evaluate the accuracy of the lung ultrasound score (LUS) in predicting ventilatory weaning failure during neonatal hospitalization in the NICU and to identify factors associated with weaning failure, including corrected gestational age (CGA). This prospective, longitudinal, pragmatic and observational cohort study included neonates on mechanical ventilation for at least 48 h. The primary outcome was the accuracy of lung ultrasound in predicting 3-day weaning failure, with the ROC curve used to determine the best LUS cutoff (sensitivity and specificity).

Mismatch negativity in children with developmental Dyslexia.

Objective: To describe and compare the latencies and amplitudes of Mismatch Negativity between children with and without Developmental Dyslexia.

Methods: Cross-sectional and comparative study, consisting of a study group of 52 children with Developmental Dyslexia and a control group of 52 children with typical development, matched by age and sex, aged between 9 years and 11 years and 11 months of both sexes. All participants underwent Otoscopy, Acoustic Immittance Measurements, Pure Tone Audiometry, Speech Audiometry, Brainstem Auditory Evoked Potential and Mismatch Negativity.

Determinants of agricultural employment during the COVID-19 pandemic: A spatial analysis of Brazilian municipalities.

The impact of COVID-19 has extended beyond the health toll it has taken on populations. The global economy has experienced significant downturns, with unemployment rates reaching unprecedented highs for this century. Nonetheless, the agricultural sector has been uniquely affected by the pandemic, particularly given its crucial role in food supply.

Association of systemic inflammation and long-term dysfunction in COVID-19 patients: A prospective cohort.

COVID-19 has significant long-term impacts, including a chronic syndrome known as long-COVID, characterized by persistent symptoms post-recovery. The inflammatory response during acute infection is hypothesized to influence long-term outcomes. This study aimed to identify inflammatory biomarkers predictive of functional outcomes one year after hospital discharge.

Magnetic Composite Carbon from Microcrystalline Cellulose to Tackle Paracetamol Contamination: Kinetics, Mass Transfer, Equilibrium, and Thermodynamic Studies.

This study reported a one-spot preparation of magnetic composite carbon (MCC@Fe) from microcrystalline cellulose (MC). The pure cellulose was impregnated in iron (III) chloride solution and carbonized at 650 °C. The MCC@Fe composite adsorbent underwent various characterization techniques.

Analysis of the Antibiotic-Potentiating Activity, Absorption, Distribution, Metabolism, and Excretion (ADME) and the Molecular Docking Properties of Phytol Against Multi-Drug-Resistant (MDR) Strains.

Phytol is a diterpene from the long-chain unsaturated acyclic alcohols, known for its diverse biological effects, including antimicrobial and anti-inflammatory activities. Present in essential oils, phytol is a promising candidate for various applications in the pharmaceutical and biotechnological sectors. This study aimed to evaluate the antibacterial and drug-potentiating effects of phytol against multidrug-resistant bacteria and to evaluate its properties: ADME and molecular docking.

Approaches to regenerative endodontic therapy in necrotic human teeth with complete root formation: a systematic review.

Introduction: Regenerative endodontic procedures (REPs) aim to replace damaged dental structures and regenerate the dentin-pulp complex. Initially focused on teeth with incomplete root formation, recent research shows promise for necrotic teeth with complete root formation.

Methodology: This review, following PRISMA guidelines and registered in PROSPERO, included clinical studies on regenerative endodontic therapy in necrotic human teeth with complete root formation.

SARS-CoV-2 strains and clinical profiles of COVID-19 patients in a Southern Brazil hospital.

Introduction: The COVID-19 pandemic had a widespread global impact and presented numerous challenges. The emergence of SARS-CoV-2 variants has changed transmission rates and immune evasion, possibly impacting the severity. This study aims to investigate the impact of variants on clinical outcomes in southern Brazil.

Gatekeeping Through Remote Family Physician Consultations in Tertiary University Hospital During the COVID-19 Pandemic: A Cross-Sectional Study.

: To explore the potential of gatekeeping for specialized consultations and patient care via remote interactions with family physicians. This cross-sectional study was conducted at a tertiary hospital between November 2020 and December 2021, when specialized consultations were canceled due to the COVID-19 pandemic. Patients who were evaluated for remote consultation with family physicians were included.

Phytotoxic Activity of O. Berg, a Dominant Myrtaceae Woodland Tree Native of Brazil.

Limited phytodiversity and regeneration rates occur in some of the southern Brazilian formations known as the Myrtacean Woodlands. Data on phytotoxicity, chemical composition, and allelopathic potential of O. Berg, a dominant species in such woodlands, is missing.

Hybrid and Plant-Based Burgers: Trends, Challenges, and Physicochemical and Sensory Qualities.

Burgers have become a staple of global cuisine and can have several different versions and combinations. For example, hybrid burgers have a percentage of animal protein in their formulation, while plant-based burgers contain 100% plant-based proteins. Therefore, the aim of this study was to investigate the emerging trends and challenges in the formulation of hybrid and plant-based burgers, with an emphasis on new ingredients and the evaluation of their physical, chemical, and sensory properties.

CNT@NiFeO nanocomposite for phenobarbital removal: adsorption study and characterization.

The contamination of seas, rivers, lakes, and groundwater by industrial, hospital, and domestic effluents is a global health problem. Scientific approaches are needed to assess and mitigate the impacts of those pollutants, seeking more sustainable alternatives that meet established environmental standards. Among the various contaminants that are released into water sources, phenobarbital (PHEN), a long-acting barbiturate, applied as a hypnotic, sedative, and in the treatment of seizures is an aquatic pollutant, raises significant concerns for human health and the environment.

Grazing intensity for enhanced resource use efficiency in integrated crop-livestock systems: Balancing soil carbon storage and food security.

Preserving natural resources while addressing global food demand is a critical responsibility of the agricultural sector. In light of this, strategically integrating domestic herbivores into crop monocultures is seen as a promising opportunity to generate additional income and improve the efficiency of food production. Our study presents long-term results from experimentation on Integrated Crop-Livestock Systems (ICLS), revealing its productive and environmental benefits.

Sarcopenia and the biological determinants of aging: A narrative review from a geroscience perspective.

Background: The physiopathology of sarcopenia shares common biological cascades with the aging process, as does any other age-related condition. However, our understanding of the interconnected pathways between diagnosed sarcopenia and aging remains limited, lacking sufficient scientific evidence.

Methods: This narrative review aims to gather and describe the current evidence on the relationship between biological aging determinants, commonly referred to as the hallmarks of aging, and diagnosed sarcopenia in humans.

Innovative Photoprotection Strategy: Development of 2-(Benzoxazol-2-Yl)[(2-Hydroxynaphthyl)Diazenyl] Phenol Derivatives for Comprehensive Absorption of UVB, UVA, and Blue Light.

Overexposure to blue light due to the excessive use of electronic devices has been implicated in premature skin aging and eye damage, among other injuries to health. This study aimed to synthesize two azo derivatives of the 2-(amino-2'-hydroxyphenyl) benzoxazole and explore their potential as UV and blue light filters, proposing a new spectral profile. The synthesis of the heterocyclic compounds involved condensation reactions and diazotation.

Clinical Staging of Alcohol Use Disorder: Proposal of a New Stratified Approach.

Introduction: Clinical staging is widely applied in various fields of Medicine. Staging makes it possible to constitute early diagnoses and interventions, improving prognosis and preventing disease progression. In relation to Alcohol Use Disorder (AUD), staging is still an underdeveloped subject in the scientific literature.

Nanoencapsulation with Eudragit® and chia mucilage increases the stability and antifungal efficacy of carvacrol against spp.

Carvacrol is a consolidated natural antimicrobial. However, its use in food is a challenge due to characteristic odour and high volatility. Nanoencapsulation has emerged to overcome these drawbacks.