Conservative Management of Pediatric Patients With Appendicolith Appendicitis Versus Non-appendicolith Appendicitis: A Systematic Review and Meta-analysis.

Introduction: Up to one-third of pediatric patients with acute appendicitis present with radiological evidence of appendicoliths. However, whether appendicolith presence influences prognosis under conservative management compared to non-appendicolith appendicitis remains uncertain.

Methods: We systematically searched PubMed, Cochrane, Embase, and Web of Science databases for studies comparing pediatric appendicolith and non-appendicolith appendicitis managed conservatively with antibiotics, fluids, and percutaneous drainage.

Degradation of Rhodamine B dye using the mesoporous material KIT-6/TiO photocatalyst obtained by in situ anchoring method.

In this study, a novel synthesis approach was employed to create the KIT-6/TiO photocatalyst with different ratios of Si/Ti. The results of the X-ray diffraction revealed that incorporating TiO with the anatase phase maintained the mesoporous structure of KIT-6 (Korean Institute of Technology 6). The scanning electron microscope and transmission electron microscope images exhibited unobstructed mesopores, validating their anchoring within the internal structure of the support.

Topical anesthetics methods used to reduce needle pain/discomfort prior to local anesthesia in children and adolescents: a scoping review.

Objectives: The aim of this study was to review the most effective topical anesthetic methods for reducing pain/discomfort prior to dental local anesthetic needle puncture for dental procedures in children and adolescents.

Methods: A scoping review was conducted. Individual search strategies were developed for each of the bibliographic databases (Cochrane, Embase, LILACS, LIVIVO, Pubmed, Scopus, PsyINFO, Web of Science), and in the gray literature (Google Scholar, Open Gray), comprehensively, without restrictions on language, publication data, or level of socioeconomic development of the country in which the study was conducted.

Metabolic signatures by LC-HRMS/MS of jabuticaba (Plinia cauliflora) juice, liqueur, and wines reveal the wealthiest sources of bioactive metabolites.

This study aimed to determine the total phenolic content, antioxidant and anti-inflammatory activities, and metabolomic profiling of Jabuticaba beverages. The metabolomic profiling showed a greater abundance of flavonoids in liqueur samples, while sweet wine predominantly contained phenolic acids. On the other hand, dry wine was characterized by a higher abundance of terpenes.

Mental health and university dropout among nursing students: A cross-sectional study.

Introduction: Various factors and motivations linked to higher education dynamics can impact professional training, academic involvement, student well-being, and dropout. Knowledge of these factors enables the adoption of more appropriate strategies to promote student retention.

Objective: Identification of potential motivations for dropping out of university and the relationship with symptoms of depression, anxiety and stress among undergraduate nursing students.

Bacillus subtilis inoculated in organic compost could improve the root architecture and physiology of soybean under water deficit.

Bacillus subtilis is known to promote root growth and improve plant physiology, while organic compost enhances soil water retention. This study explored the combined effect of inoculating B. subtilis in organic compost on soybean growth under water deficit.

Insights into the representativeness of biodiversity assessment in large reservoir through eDNA metabarcoding.

Monitoring biodiversity on a large scale, such as in hydropower reservoirs, poses scientific challenges. Conventional methods such as passive fishing gear are prone to various biases, while the utilization of environmental DNA (eDNA) metabarcoding has been restricted. Most eDNA studies have primarily focused on replicating results from traditional methods, which themselves have limitations regarding representativeness and bias.

Microencapsulated Escape Lysine with Tannin as an Adjuvant in Sheep Diets.

The use of escape protein, which is absorbed in the small intestine, can improve the production of ruminant animals because it meets their protein requirements better. This study hypothesized that wax lipid matrices are effective encapsulants for escape lysine in ruminants and tested tannin extract as an adjuvant. Forty intact male Santa Ines × Dorper sheep (~4 months old, BW 23 ± 1.

Biotechnological Perspectives on the Therapeutic Potential of Phenylpropanoid Cinnamaldehyde in Inflammatory Diseases: Signaling Pathways.

The traditional use of plants of the Cinnamomum genus dates back to traditional Eastern medicine for millennia and they have also been used in Western integrative medicine practices, especially for their anti-inflammatory activity. In the context of chemical diversity, the absolute majority of species in this genus have cinnamaldehyde as the majority component, which in turn holds the title of the active ingredient, whose biological effect profile has already been demonstrated in numerous experiments in acute and chronic inflammatory conditions. In this context, the objective of this research was to investigate how cinnamaldehyde can influence inflammatory phenomena.

Efficacy of birthing ball exercises to reduce labor pain and cesarean rates: an updated meta-analysis of randomized controlled trials.

Purpose: This updated systematic review and meta-analysis aims to evaluate the impact of a birthing ball (BB) exercises on low-risk parturients during labor, offering a more comprehensive understanding through a larger sample size, robust analysis, and focus on relevant endpoints that were underexplored in previous studies due to limited data.

Methods: We searched PubMed, Embase, Scopus, and Cochrane Central for randomized controlled trials (RCTs) comparing BB (also named Swiss ball) exercises with no intervention or standard care in parturients undergoing low-risk labor. Risk ratios (RR) and mean differences (MD) were calculated using a random-effects model.

Statin use and dementia risk: A systematic review and updated meta-analysis.

Unlabelled: Dementia affects 55 million people globally, with the number projected to triple by 2050. Statins, widely prescribed for cardiovascular benefits, may also have neuroprotective effects, although studies on their impact on dementia risk have shown contradictory results. In this systematic review and meta-analysis, we searched PubMed, Embase, and Cochrane following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.

Buthionine sulfoximine acts synergistically with doxorubicin as a sensitizer molecule on different tumor cell lines.

The chemotherapeutic drug doxorubicin (DOX) has been widely used for treating solid tumors attributed to its antiproliferative effectiveness; however, its clinical use is limited due to side effects, including cardiotoxicity, myelosuppression, and drug resistance. Combining DOX with buthionine sulfoximine (BSO), a glutathione (GSH) synthesis inhibitor, showed promising results in overcoming these adverse effects, potentially reducing the required DOX dose while maintaining efficacy. The aim of the present study was to examine the effects of different concentrations of BSO and DOX, both individually and in combination, utilizing B16/F10 (murine melanoma), SNB-19 (human glioblastoma), S180 (murine sarcoma), and SVEC4-10 (murine endothelial) cell lines.

Efficacy and safety of intravenous tirofiban in patients with acute ischemic stroke due to large artery atherosclerosis undergoing endovascular thrombectomy: A systematic review and meta-analysis.

Introduction: Intravenous tirofiban (IT) is shown to be potentially effective in acute ischemic stroke (AIS) patients submitted to mechanical thrombectomy, despite its safety and efficacy are not well established. However, there is a lack of evidence on the effects of IT on endovascular thrombectomy (EVT) in patients with AIS due to large artery atherosclerosis (LAA).

Objectives: To assess the safety and efficacy of IT in AIS patients due to LAA submitted to EVT.

Reach and engagement on the history of nursing on social media in light of Pierre Lévy.

Objective: To analyze the reach and engagement on the history of nursing on social media of the Memory Center of the School of Nursing, Federal University of Minas Gerais (CEMENF/UFMG), in light of Pierre Lévy.

Methods: Documentary study carried out on CEMENF's Instagram and on the YouTube of the School of Nursing of UFMG, from September to December 2021. The findings were analyzed according to Pierre Lévy's concepts.

Novel tryptophyllin peptides from Physalaemus centralis inhibit oxidative stress-induced endothelial dysfunction in rat aorta preparation.

Amphibian skin is a rich source of molecules with biotechnological potential, including the tryptophyllin family of peptides. Here, we report the identification and characterization of two tryptophyllin peptides, FPPEWISR and FPWLLS-NH, from the skin of the Central Dwarf Frog, Physalaemus centralis. These peptides were identified through cDNA cloning and sequence comparison.

BidCorpus: A multifaceted learning dataset for public procurement.

Digital transformation has significantly impacted public procurement, improving operational efficiency, transparency, and competition. This transformation has allowed the automation of data analysis and oversight in public administration. Public procurement involves various stages and generates a multitude of documents.

3D-Printed PCL-Based Scaffolds with High Nanosized Synthetic Smectic Clay Content: Fabrication, Mechanical Properties, and Biological Evaluation for Bone Tissue Engineering.

Background: The 3D printing of macro- and mesoporous biomimetic grafts composed of polycaprolactone (PCL) infused with nanosized synthetic smectic clay is a promising innovation in biomaterials for bone tissue engineering (BTE). The main challenge lies in achieving a uniform distribution of nanoceramics across low to high concentrations within the polymer matrix while preserving mechanical properties and biological performance essential for successful osseointegration.

Methods: This study utilized 3D printing to fabricate PCL scaffolds enriched with nanosized synthetic smectic clay (LAP) to evaluate its effects on structural, chemical, thermal, mechanical, and degradative properties, with a focus on in vitro biological performance and non-toxicity.

Aroeira (Myracrodruon urundeuva) and Malva (Herissantia crispa) have forage potential for ruminant nutrition in arid regions.

The Caatinga biome has a wide variety of plants which, despite their irregular distribution, are frequently used to feed animals. This study aimed to evaluate the gas production kinetics of Caatinga plants: Malva (Herissantia crispa), Aroeira (Myracrodruon urundeuva), Marmeleiro (Croton sonderianus), and Bamburral (Hyptis suaveolens). Buffel grass (Cenchrus ciliaris), a cultivated forage, was used as a control.

Investigation of bacterial nanocellulose/calcium phosphates-based composite containing cerium for bone repair.

Bacterial nanocellulose (BNC) has attracted considerable attention in the field of biomedical engineering due to its potential for use in bone regeneration applications. The present study investigates the in vitro and in vivo efficacy of bacterial nanocellulose (BNC) combined with calcium and cerium ions (BNC-Ce:CaP) in bone regeneration applications. XRD analysis confirmed the presence of monetite and hydroxyapatite phases in BNC-CaP, while BNC-Ce:CaP revealed an additional brushite phase.

Anthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom .

With praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Berk. resulted in the isolation of new conjugated long-chain fatty acids (8,10,12,13)-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid () and (7,8,9,11)-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid () and three previously described compounds, (7,8,9)-7,8-dihydroxyoctadec-9-enoic acid (), (2)-dec-2-ene-1,10-dioic acid (), and a ketolactone marasmeno-1,15-dione ().

Statins as potential disease-modifying therapy of Parkinson's disease: a systematic review and meta-analysis with trial sequential analysis.

Background: Recent evidence indicates that statins have anti-inflammatory and antioxidant effects, leading to several investigations of whether statins have a neuroprotective effect and may benefit patients with Parkinson's disease (PD). However, the potential mechanisms of this class of medications as modifiers of the course of PD in already diagnosed patients is still unclear.

Objectives: To assess the effectiveness of statins as modifiers of established PD.

Synthesis of Silver Nanoparticles and Evaluation of Antimicrobial Activity Using the Aqueous Extract of Pterodon emarginatus Seeds.

The decline in research for new antimicrobials, combined with the rise in bacterial resistance, has become a critical issue that is expected to worsen over time. As an alternative, health sciences have integrated materials engineering to develop new bioactive compounds through the interaction of nanoparticles with plant-derived compounds. These compounds offer advantages such as high bioavailability and low cost, exemplified by , a plant native to the Brazilian Cerrado.

Single-Step Deposition of Chalcopyrite (CuFeS) Thin Films.

Thin films of chalcopyrite, CuFeS, are promising candidates for use as absorber layers in photovoltaic cells due to their low band gap and high absorbance. These films are typically deposited in two or three steps, always involving an annealing process. In this work, the CuFeS film was deposited on a glass substrate in a single deposition step using the cathodic cylindrical plasma deposition (CCyPD) technique.

Polyacrylamide Hydrogel Containing Starch and Sugarcane Bagasse Ash: Synthesis, Characterisation, and Application in Cement Pastes and Mortars.

Internal curing is a process based on the addition of materials that function as water reservoirs in cementitious media. Superabsorbent hydrogels are an alternative that can be used as an internal curing agent, as they have the ability to absorb and release water in a controlled manner. In the present work, superabsorbent hydrogels based on crosslinked polyacrylamide in the presence of starch and sugarcane bagasse ash (SCBA) were developed and applied to mortars as an internal curing agent.