58 results match your criteria: "Federal University of Parana - Curitiba[Affiliation]"
Tyrosine kinase inhibitors in patients with chronic myelogeneous leukemia: defining the role of social risk factors and non-adherence to treatment.
Pharm Pract (Granada)
July 2015
Hematopoietic Stem Cell Transplantation Division, Clinical Hospital, Federal University of Paraná . Curitiba, PR ( Brazil ).
Objective: To assess the role of social risk factors on adherence to tyrosine kinase inhibitors (TKI) therapy in chronic myeloid leukemia (CML) patients.
Methods: This is a retrospective study and eligible patients were adults with CML on TKI treatment. Cases of no adherence to treatment were confirmed during pharmacists' consultation (patient-reported adherence).
The use of prebiotics during the first year of life for atopy prevention and treatment.
Immun Inflamm Dis
October 2013
Head of Pediatric Allergy Service, Clinics Hospital, Federal University of Paraná Curitiba, Parana, Brazil.
The incidence of allergic diseases has increased in recent decades. Therefore, the aim of this systematic review was to assess the efficacy of prebiotics for the prevention and treatment of allergic manifestations in children. We sought to conduct a systematic review of the effectiveness of prebiotics in the prevention and treatment of allergic diseases in children.
View Article and Find Full Text PDFA non-canonical landscape of the microRNA system.
Front Genet
October 2014
Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná Curitiba, Brazil.
Microribonucleic acids, best known as microRNAs or miRNAs, are small, non-coding RNAs with important regulatory roles in eukaryotic cells. Here, I present a broad review on highly relevant but generally non-depicted features of miRNAs, among which stand out the non-conventional miRNA seed sites, the unusual messenger RNA (mRNA) target regions, the non-canonical miRNA-guided mechanisms of gene expression regulation, and the recently identified new class of miRNA ligands. Furthermore, I address the miRNA uncommon genomic location, transcription, and subcellular localization.
View Article and Find Full Text PDF'Pseudo-Dominant' Inheritance in Friedreich's Ataxia: Clinical and Genetic Study of a Brazilian Family.
Mov Disord Clin Pract
December 2014
Article Synopsis
- Friedreich's ataxia (FA) is an inherited disorder that causes progressive difficulties in movement, heart problems, muscle weakness, and reflex issues, along with other symptoms such as loss of sensory perception and speech difficulties.
- The diverse range of symptoms can complicate diagnosis, and understanding the inheritance pattern can provide important clues; a rare "pseudodominant" inheritance pattern may also manifest, complicating this further.
- A study was conducted on a Brazilian family of Italian descent, where sibling variations in symptoms highlighted the complexity of FA's diagnosis.
Freezing of Gait 3 Years After Bilateral Globus Pallidus Internus Deep Brain Stimulation in Generalized Dystonia.
Mov Disord Clin Pract
September 2014
Low hepatitis B vaccine response in children with Down syndrome from Brazil.
Child Care Health Dev
July 2014
Department of Medicine, University Positivo, Curitiba, Paraná, Brazil; Laboratory of Immunopathology, Clinical Hospital, Federal University of Paraná Curitiba, Curitiba, Paraná, Brazil.
Article Synopsis
- Vaccination against hepatitis B in children with Down syndrome is less effective, with only 48.3% showing a positive immune response post-vaccination.
- A study involving 120 Brazilian children with Down syndrome showed no significant difference in vaccine response based on gender or age.
- These findings highlight the need for ongoing monitoring and support for Down syndrome patients receiving the hepatitis B vaccine.
Targeting IL-23: insights into the pathogenesis and the treatment of psoriasis.
Indian J Dermatol
July 2011
Department of Medical Pathology, Federal University of Parana - Curitiba, PR - Brazil.
Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis. Studies with anti-IL-12/23 therapeutic agents, which act in different steps of the psoriatic inflammatory cascade, have also shown demonstrable efficacy. Here, we discuss this approach and its potential within the armamentarium for the treatment of psoriasis.
View Article and Find Full Text PDFRhinitis is also common in infants with asthma.
Iran J Allergy Asthma Immunol
March 2010
Pediatric Allergy Division, Federal University of Paraná Curitiba, Paraná, Brazil.
The aim of this study was to assess the frequency of rhinitis in asthmatic infants. A cross-sectional study was conducted using clinical data obtained from a standardized allergy work-up form that includes specific questions on common allergic diseases. Asthmatic patients were seen at the first visit to the Pediatric Allergy Unit, from January 2001 to January 2006, were selected for analysis.
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