Adherence in Evidence-Based Neurotrauma Guidelines: A Worldwide Survey.

Background: Traumatic brain injury (TBI) management guidelines vary across regions and there is limited research on real-world adherence to these guidelines. We conducted a global survey to assess the adherence of neurosurgeons to TBI guidelines and evidence-based medicine (EBM).

Method: A 24-item survey was created using Google Forms, covering demographic information, neurotrauma training, basic knowledge of EBM, surgical and in-hospital management.

Impact of health conditions on non-medical costs: a time series analysis of disability insurance and hospital medical costs in Brazil (2010-2019).

Background: Disability insurance represents a significant economic burden within Brazil's social security system, yet long-term cost trends across disease groups remain understudied, hindering informed prevention and management strategies. Hospital costs, which account for approximately 40% of direct healthcare expenses, were selected as a comparative reference to contextualize the economic burden of disability insurance.

Objective: This study analyzes long-term cost trends of newly granted disability insurance by disease groups in Brazil, comparing them to public health system hospitalization expenses.

Water pollution caused by ash from grassland fires alters the molecular, biochemical, and morphological biomarkers of non-biting midge larvae.

The frequency and intensity of wildfires have been increasing in many parts of the world, which may result in biodiversity loss. Wildfires can devastate plant communities, generating toxic ash that pollutes watercourses through runoff. However, our understanding of the effects of ash exposure on aquatic biodiversity is still limited.

Proximal tibial osteotomies for treating grade IV medial patellar luxation in two feline stifles.

Objectives: There is a lack of literature regarding the surgical management of high-grade patellar luxation in cats. Among the available options, corrective osteotomies are suitable for correcting severe bone deformities. Therefore, this study aimed to report on the surgical management of grade IV medial patellar luxation (MPL) through tibial corrective osteotomies in two cats.

Oral pemphigus vulgaris diagnostic characteristics and treatment: a systematic review.

Pemphigus vulgaris (PV) is a rare, potentially fatal, immune-mediated chronic disease characterized by the presence of bullous intraepithelial lesions on mucous membranes and skin. This study aimed to perform a systematic literature review covering PV clinical and histopathological aspects and treatment. The literature searches were carried out in the Pubmed, Periódicos Capes, Scopus, Science Direct, Web of Science and Scielo databases.

Deciphering surface water-groundwater connectivity using chemical and stable isotope tracers (H and O) in the headwaters of São Francisco River, Brazil.

This study assessed the chemical composition of major elements and stable isotopes (H and O) in precipitation, groundwater, and surface water in São Francisco 1 (SF1) sub-basin (approximately 14,000 km), located at the São Francisco River headwater region, fractured aquifer system region with a complex geologic framework. Both groundwater and surface water exhibited low mineral content, with average electrical conductivity of 147.2 ± 99.

The impact of COVID-19 on breast cancer mortality trends in Brazil: A time-series study.

Background: There is a lack of research on whether COVID-19 disruptions in breast cancer screening, diagnosis, and treatment affected mortality rates over time.

Method: This ecological time series study, covering the period between 2013 and 2023, utilizes the inflection point regression model and calculates the Annual Percentage Change (APC). The study used open-access data from the Brazilian Mortality Information System.

Effects of DC on an Innovative Animal Model of Cardiometabolic Syndrome.

Cardiometabolic syndrome (CMS) is a complex clinical condition that encompasses metabolic dysregulation, cardiovascular disease, and diabetes risk factors. Worldwide, CMS is underdiagnosed, and its occurrence significantly increases cardiovascular morbimortality. Despite available pharmacological treatments, the approach is fragmented, and the associated clinical conditions are treated independently.

Effect of physical therapy on the isokinetic performance of knee flexors and extensors and functional balance in older adults with Parkinson's disease, according to severity.

Objective: To analyze the effects of a physical therapy intervention on the muscle strength and power of the knee flexors and extensors and functional balance in older adults with Parkinson's disease (PD), according to its clinical severity.

Methods: Forty older adults diagnosed with PD were evaluated before and after 48-week of a basic exercise program (two 20-min sessions a week) to improve functional balance and quadriceps strength. The variables analyzed were: motor aspects of PD, assessed using the Unified Parkinson's Disease Rating Scale (UPDRS); functional mobility; peak torque (PT) and mean power (MP) at the knee flexors and extensors, evaluated using an isokinetic dynamometer (CYBEX®) on both legs at 60°/s (PT) and 240°/s (P); Timed Up and Go (TUG) test; and Tinetti Index.

Application of OSA-VET and qualiquantitative tear tests in brachycephalic dogs with and without keratoconjunctivitis sicca.

The aim was to compare the outcomes acquired from the OSA-Vet device with conventional quantitative and qualitative tear tests and between groups within each test, in brachycephalic dogs both healthy and those diagnosed with keratoconjunctivitis sicca. The dogs were divided into four groups: healthy dogs (HD), with mild KCS (MIKCS); moderate KCS (MOKCS); severe KCS (SKCS). All patients underwent ocular surface diagnostic examination in the following order, with a 10-minute interval between tests: non-invasive tear film breakup time (TBUTNI - OSA-Vet), tear meniscus height (TMH-OSA-Vet), meniscometry (I-Tear test), Schirmer Tear Test-1 (STT-1), and tear film breakup time (TBUT).

Estimation of genetic parameters for racing time and ranking in Thoroughbred horses.

This study aimed to estimate genetic parameters for race time in seconds and final ranking, as well as to analyze the genetic trends associated with race time. The study utilized a dataset consisting of 23,290 records of race times and final ranks at distances of 1,000, 1,600, and 2,000 m from 6,213 Thoroughbred horses from the São Paulo Jockey Club. Our model considered the year of the run, animal sex, race class, track conditions, the linear effect of horse weight and age, and the quadratic effect of age as fixed covariates.

The effect of protease supplementation in broiler chicken diets containing maize from different batches on growth performance and nutrient digestibility.

Maize is the primary energy source in poultry diets. Nutritional and physical traits related to maize composition can affect nutrient utilization, as well as the efficacy of exogenous enzymes. A study was conducted to evaluate the effect of maize from different batches and protease supplementation on growth performance and ileal nutrient digestibility of broiler chickens from 1 to 40 days of age.

Induction of ectosome formation by binding of phospholipases D from Loxosceles venoms to endothelial cell surface: Mechanism of interaction.

Members of the phospholipase D (PLD) superfamily found in Loxosceles spider venoms are potent toxins with inflammatory and necrotizing activities. They degrade phospholipids in cell membranes, generating bioactive molecules that activate skin cells. These skin cells, in turn, activate leukocytes involved in dermonecrosis, characterized by aseptic coagulative necrosis.

Hidden diversity in anthropophilic sand flies of the Monticola Series (Diptera, Psychodidae).

The Monticola series comprises two anthropophilic and widely distributed species in Brazil: Pintomyia (Pifanomyia) monticola (Costa Lima, 1932) and Pintomyia (Pifanomyia) misionensis (Castro, 1959). They mainly occur in the Atlantic Rainforest, and it is known that Pi. monticola comprises at least two well-structured genetic lineages regarding a fragment of the cytochrome c oxidase subunit I (COI) gene.

A novel electrochemical immunosensor for the determination of tuberculosis diagnosis exploiting graphene-affinity peptide.

Conventional methods for diagnosing tuberculosis (TB), a significant global health challenge, often have drawbacks like time-consuming procedures, limited sensitivity, and the need for complex, expensive infrastructure. Hence, the development of electrochemical immunosensors has emerged as a promising strategy for TB detection due to their simplicity, speed, sensitivity, portability, and cost-effectiveness. In this study, we developed a rapid, simple, and low-cost immunosensor using a lab-made screen-printed electrode (SPE) based on the peptide TB 68-G as a recognition site.

The negative impact of the COVID-19 pandemic on breast cancer care in Brazil: a time series study in regions with different human development indices.

Background: The impact of the COVID-19 pandemic on breast cancer care across Brazilian regions with varying Human Development Index (HDI) levels remains unclear. This study evaluates the pandemic's effects on screening mammograms, tumor staging at diagnosis, and treatment initiation in the Brazilian Public Health System between 2017 and 2022, focusing on regions with different HDI levels.

Methods: This ecological time series study uses an inflection point regression model and monthly percentage change (MPC) to analyze an open-access Brazilian Public Healthcare System dataset.

3D Digital and Printed Hearts from Different Canine Breeds as an Educational Tool for Radiographic Interpretation.

Three-dimensional (3D) printing is a new method of creating anatomical models, which can enhance the training of students and health professionals. The large breed-variation in dogs means that interpretation of thoracic radiographs can be challenging for the inexperienced radiologist. The aim of this study was to develop digital and printed 3D cardiac models from six canine breeds and evaluate their use as a tool for studying breed variations in radiology.

The negative impact of the COVID-19 pandemic on breast cancer tackle in Brazil's public and private healthcare system: time series study between 2014 and 2022.

Background: The COVID-19 pandemic has overwhelmed the healthcare systems of many countries and negatively impacted the care of other diseases.

Objective: To evaluate the trend of screening mammograms, oncological breast surgeries, and breast cancer hospitalizations in Brazil's public and private healthcare system between 2014 and 2022.

Method: This ecological time series study uses the inflection point regression model and semester percentage change (SPC).

Symptomatology and IgG Levels before and after SARS-CoV-2 Omicron Breakthrough Infections in Vaccinated Individuals.

(1) Background: After the COVID-19 pandemic, there is concern regarding the immunity of the population to SARS-CoV-2 variants, particularly the Omicron variant and its sub-lineages. (2) Methods: The study involved analyzing the immune response and symptomatology of 27 vaccinated individuals who were subsequently infected by Omicron sub-lineages. Blood samples were collected for serological analysis, including the detection of IgG antibodies reactive to the Nucleocapsid (N) and Spike (S) antigens of SARS-CoV-2.

Assessment of left atrial function using tissue motion annular displacement in healthy dogs.

Objectives: Recently, tissue motion annular displacement by speckle tracking has been shown to be a reliable method for evaluating deformation of the left atrium in healthy dogs. The aim of this study was to investigate whether tissue motion annular displacement is a feasible alternative method for studying left atrial function.

Materials And Methods: One hundred healthy dogs were included.

Long-Term Nose Evaluation After Treatment of Bilateral Cleft Lip Using the Spina Technique.

Introduction: Bilateral cleft lip (BCL) repair is a challenge due to anatomic and functional distortions, worse than unilateral cleft. With regard to the nose, BCL can result in certain characteristics, such as a short columella, a flattened and widened tip, and horizontally oriented nostrils. Lip and nose treatment is advocated by some surgeons to achieve a better outcome.