Differential amino acid usage leads to ubiquitous edge effect in proteomes across domains of life that can be explained by amino acid secondary structure propensities.

Amino acids are the building blocks of proteins and enzymes which are essential for life. Understanding amino acid usage offers insights into protein function and molecular mechanisms underlying life histories. However, genome-wide patterns of amino acid usage across domains of life remain poorly understood.

Symptomatology and IgG Levels before and after SARS-CoV-2 Omicron Breakthrough Infections in Vaccinated Individuals.

(1) Background: After the COVID-19 pandemic, there is concern regarding the immunity of the population to SARS-CoV-2 variants, particularly the Omicron variant and its sub-lineages. (2) Methods: The study involved analyzing the immune response and symptomatology of 27 vaccinated individuals who were subsequently infected by Omicron sub-lineages. Blood samples were collected for serological analysis, including the detection of IgG antibodies reactive to the Nucleocapsid (N) and Spike (S) antigens of SARS-CoV-2.

Morphophysiological Adaptations of Aquatic Macrophytes in Wetland-Based Sewage Treatment Systems: Strategies for Resilience and Efficiency under Environmental Stress.

There is a common misconception that aquatic macrophytes face significant challenges in wetland-based sewage treatment systems. This study aims to correct this perception by focusing on the crucial morphophysiological adaptations of aquatic macrophytes that enable them to thrive in wetland-based sewage treatment systems, particularly under environmental stress. These adaptations are vital for improving the efficiency and resilience of wastewater treatment processes, offering sustainable solutions in the face of variable environmental conditions and complex contaminant mixtures.

Development and Characterization of Film-Forming Solution Loaded with (L.) Skeels for Topical Application in Post-Surgical Therapies.

Background/objectives: Considering the antioxidant and antimicrobial properties attributed to compounds in extract, this research aimed to advance postoperative therapeutic innovations. Specifically, the study assessed the physicochemical properties of a film-forming solution (FFS) incorporated with , evaluating its therapeutic potential for postoperative applications.

Methods: The extract was meticulously characterized to determine its chemical composition, with particular emphasis on the concentration of phenolic compounds.

Clinical Pathology Evaluation in Pet Rabbits Vaccinated Against Rabbit Hemorrhagic Disease Virus 2 (RHDV2).

A recombinant vaccine for rabbit hemorrhagic disease virus 2, a highly pathogenic virus, was granted emergency use authorization in the United States after the detection and spread of the virus starting in 2018. The goal of the current study was to assess pet rabbits (n = 29) through physical examination and routine clinical pathology testing using repeated assessments post-vaccination. In addition, seroconversion was also monitored after the initial vaccination and booster vaccination.

Ultra-Pressurized Deposition of Hydrophobic Chitosan Surface Coating on Wood for Fungal Resistance.

Fungi (, , and , ) impart wood rot, leading to economic and environmental issues. To overcome this issue, toxic chemicals are commonly employed for wood preservation, impacting the environment and human health. Surface coatings based on antimicrobial chitosan (CS) of high molar mass (145 × 10 Da) were tested as wood preservation agents using an innovative strategy involving ultra-pressurizing CS solutions to deposit organic coatings on wood samples.

Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis.

Propolis possesses many bioactive compounds that could modulate the gut microbiota and reduce the production of uremic toxins in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This clinical trial aimed to evaluate the effects of propolis on the gut microbiota profile and uremic toxin plasma levels in HD patients. These are secondary analyses from a previous double-blind, randomized clinical study, with 42 patients divided into two groups: the placebo and propolis group received 400 mg of green propolis extract/day for eight weeks.

Efficacy of Type III Thyroplasty in Vocal Masculinization in Trans Men: A Retrospective Observational Study.

Objective: This observational study aims to evaluate the efficacy of type III thyroplasty (TP3) in achieving vocal masculinization in transgender men who have not obtained satisfactory results from testosterone therapy alone. Specifically, it aims to determine the change in the fundamental frequency (F0) of the voice before and after surgery and compare the results with previous studies.

Study Design: A retrospective observational study.

Pharmacological evaluation of a new nanoformulation in the erectile tissue of rabbits and humans.

The failure of achieving a penile erection for satisfactory sexual intercourse is known as erectile dysfunction (ED). The primary mediator for penile erection is nitric oxide (NO). ED is often associated with endothelial/nitrergic dysfunction characterized by a reduction of the bioavailability of NO.

Breast and axillary marking in the neoadjuvant setting: survey results from experts of the Brazilian society of mastology.

Introduction/objectives: The precise location of the tumor site is essential for the success of surgical treatment. Neoadjuvant chemotherapy (NAC) is a challenge for preoperative tumor and node localization. Thus, the knowledge and attitudes of the affiliated members of the Brazilian Society of Mastology (SBM) regarding breast and axilla marking were evaluated and a consensus regarding management and treatment was reached.

Impacts of PM exposure near cement facilities on human health and years of life lost: A case study in Brazil.

Cement factories significantly contribute to atmospheric pollution by generating fine particulate matter (PM), which can potentially increase the mortality risk. The lack of information on the health impacts of PM pollution from cement operations in Brazil prompted this investigation. We used corrected PM measurements from low-cost sensors from March 2021 to October 2022 in Rio Branco do Sul, city in the southern region of the country and home to Latin America's largest cement plant, to assess exposure data.

The Mesoionic 1,3,4-thiadiazolium Derivative, MI-D, is a Potential Drug for Treating Glioblastoma by Impairing Mitochondrial Functions Linked to Energy Provision in Glioma Cells.

Background: Mesoionic compound MI-D possesses important biological activities, such as antiinflammatory and antitumoral against melanoma and hepatocarcinoma. Glioblastoma is the most aggressive and common central nervous system tumor in adults. Currently, chemotherapies are not entirely effective, and the survival of patients diagnosed with glioblastoma is extremely short.

One Health Index applied to countries in South America.

Introduction: The One Health concept has proposed an integrated and unified approach aiming for health balance and enhancement by recognizing the interdependence of human, animal, and environmental health. The COVID-19 pandemic has pushed global One Health initiatives and policy improvement toward preventive measures for future pandemics, particularly of zoonotic origin. Such a scenario may be particularly relevant for South America, which is considered highly vulnerable due to its natural biodiversity superposed to socioeconomic and environmental issues, demanding effective methods and indicators for proper One Health strategies and goals that are aligned with macroregional contexts.

Assessment of left atrial function using tissue motion annular displacement in healthy dogs.

Objectives: Recently, tissue motion annular displacement by speckle tracking has been shown to be a reliable method for evaluating deformation of the left atrium in healthy dogs. The aim of this study was to investigate whether tissue motion annular displacement is a feasible alternative method for studying left atrial function.

Materials And Methods: One hundred healthy dogs were included.

Subcutaneous rapid-acting insulin analogues in mild to moderate diabetic ketoacidosis: A meta-analysis of randomized controlled trials.

Introduction: Diabetic Ketoacidosis (DKA) is commonly treated with intravenous (IV) regular insulin. However, patients with less severe DKA may benefit from a subcutaneous (SC) scheme.

Methods: We systematically searched PubMed, Cochrane, and Embase for randomized controlled trials (RCTs) comparing SC rapid-acting insulin analogue (RAIAs) with IV regular insulin.

Translabyrinthine versus Retrosigmoid Approach for Vestibular Schwannoma: A Systematic Review and An Updated Meta-Analysis.

Objective: Several approaches can be used in the surgical treatment of vestibular schwannoma (VS), and the best approach remains uncertain in the literature. This systematic review and meta-analysis aim to compare the translabyrinthine approach (TLA) with the retrosigmoid approach (RSA) for VS in terms of postoperative complications.

Data Sources: PubMed, Web of Science, Embase, and Cochrane.

Diagnosis and management of a severe uremic stomatitis: Case report of multiple clinical features.

Uremic stomatitis is an underreported disease that occurs in the oral mucosa, associated with high levels of blood urea in patients with chronic kidney disease. This case report describes a 36-year-old male patient with severe and multiple oral manifestations of uremic disease. Intraoral examination revealed ulceration, atrophic and hemorrhagic areas were seen on the ventral surface of the tongue, floor of the mouth, and buccal mucosa.

Determinants of quality of life decrease in family caregivers of care-dependent patients: a longitudinal study.

Purpose: Family caregivers of care-dependent patients experience a decline in their Quality of Life (QoL). However, the determinants contributing to this decrease in QoL are still not fully understood. Therefore, this study aimed to estimate prospectively the determinants contributing to decreased QoL among family caregivers of care-dependent patients.

Irrigation with fibrinolytic agents versus saline for percutaneous drainage of abdominal abscesses: A meta-analysis with trial sequential analysis of randomized trials.

Introduction: Fibrinolytic agents (FA) activate the fibrinolytic system, converting plasminogen into plasmin to break down fibrin. Their use for irrigation of abdominal abscesses is debated, and this meta-analysis evaluates their efficacy.

Methods: We searched PubMed, Embase, and Cochrane Central for randomized controlled trials (RCTs) comparing FA and saline in percutaneous drainage of abdominal abscesses.

An overview of soil and plant assessment for predicting site quality and recovery strategies of one the largest tailings dam failures worldwide.

Brazil's Fundão dam collapse is one of the world's largest disasters of tailing dam failures. Previous research has evaluated toxic metals and non-metals (Cd, Cr, Ni, Pb, As, Hg) in the same soil samples used in this study, and results have indicated that only Fe and Mn concentrations increased above the original baseline (Melo et al., 2023).