One-pot synthesis at room temperature of epoxides and linalool derivative pyrans in monolacunary NaPWO-catalyzed oxidation reactions by hydrogen peroxide.

In this work, we describe a new one-pot synthesis route of valuable linalool oxidation derivatives (, 2-(5-methyl-5-vinyltetrahydrofuran-2-yl propan-2-ol) (1a)), 2,2,6-trimethyl-6-vinyltetrahydro-2-pyran-3-ol (1b) and diepoxide (1c), using a green oxidant (, hydrogen peroxide) under mild conditions (, room temperature). Lacunar Keggin heteropolyacid salts were the catalysts investigated in this reaction. Among them, NaPWO was the most active and selective toward oxidation products.

An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model.

Background: Around 300 million people world-wide suffer from asthma, and the prevalence of allergic diseases has increased. Much effort has been used in the study of mechanisms involved in the immune response observed in asthma to intervene for the treatment of this condition. During inflammation in asthma, Th2 cytokines and eosinophils are essential components of the host immune system.

Immunization with SmIg, a novel tegument protein from Schistosoma mansoni, fails to induce protection in mice but reduces liver pathology.

Proteins associated with the schistosome tegument are of great importance for the development of new intervention strategies since they may be exposed on the surface of the parasite. Herein, we have isolated a cDNA clone encoding for the Schistosoma mansoni SmIg and its recombinant protein was tested as a potential vaccine candidate. Initially, its amino acid sequence was analysed by bioinformatics and shown to possess an N-terminal signal peptide, a C-terminal transmembrane helix, 4 glycosylation sites, an immunoglobulin conserved domain and 73% similarity with a hypothetical S.