Leishmania sp. can affect the cardiovascular system of dogs - A systematic review of over 80 years.

Cardiovascular involvement in Leishmania sp. infections still requires further elucidation, with cutaneous and organic changes being more frequently observed. The aim of this study was to conduct a systematic review of cardiovascular involvement in dogs with canine visceral leishmaniasis, considering a publication span of over 80 years.

Case Report: osteonecrosis of the maxilla and mandible related to trastuzumab, docetaxel and carboplatin.

We present a case of a patient with HER-2 positive breast cancer who developed extensive areas of osteonecrosis in the mandible and maxilla due to the combination of trastuzumab, carboplatin, and docetaxel. The pathogenesis is discussed based on the literature.

High-Energy Nutrition in Hospitalised Paediatric Patients With Congenital Heart Disease: A Systematic Review and Meta-Analysis.

Aims: Congenital heart disease (CHD) is a significant cause of growth failure and neonatal mortality worldwide, and requirement-focused nutritional management can deeply impact the prognosis. Despite multiple trials, there is no published meta-analysis on the impact of high-energy nutrition in this population.

Methods: We searched PubMed, Embase and Cochrane Central for RCTs comparing high-energy to standard formulas in hospitalised patients.

Venom from Spiders Collected in Southeastern and Northeastern Brazilian Regions Cause Hemotoxic Effects on Human Blood Components.

Spiders of the genus represent a public health problem in Brazil due to the severity of the cutaneous and systemic effects that may result from their bite. In the systemic form of loxoscelism, hemolytic anemia, thrombocytopenia, and disseminated intravascular coagulation can occur. Despite the seriousness of accidents, the venom of some species has not yet been properly characterized considering these hemotoxic effects, such as that of , , and .

Biodegradation of trimethoprim and sulfamethoxazole in secondary effluent by microalgae-bacteria consortium.

Trimethoprim (TMP) and sulfamethoxazole (SMX) are bacteriostatic agents, which are co-administered to patients during infection treatment due to their synergetic effects. Once consumed, TMP and SMX end up in wastewater and are directed to municipal wastewater treatment plants (WWTPs) which fail to remove these contaminants from municipal wastewater. The discharge of WWTP effluents containing antibiotics in the environment is a major concern for public health as it contributes to the spread of antimicrobial resistance.

Bioengineering stimuli-responsive organic-inorganic nanoarchitetures based on carboxymethylcellulose-poly-l-lysine nanoplexes: Unlocking the potential for bioimaging and multimodal chemodynamic-magnetothermal therapy of brain cancer cells.

Regrettably, glioblastoma multiforme (GBM) remains the deadliest form of brain cancer, where the early diagnosis plays a pivotal role in the patient's therapy and prognosis. Hence, we report for the first time the design, synthesis, and characterization of new hybrid organic-inorganic stimuli-responsive nanoplexes (NPX) for bioimaging and killing brain cancer cells (GBM, U-87). These nanoplexes were built through coupling two nanoconjugates, produced using a facile, sustainable, green aqueous colloidal process ("bottom-up").

Health literacy assessment of individuals with and without Chagas disease: a cross-sectional study.

Background: Chagas disease (CD) is neglected that affects vulnerable individuals, whose majority has low ability to understand health information.

Objectives: To assess health literacy and its association with sociodemographic, clinical, and quality of life (QoL) characteristics.

Design And Setting: A cross-sectional study the participants with Chagas disease (ChD) were identified through serological diagnosis during blood donation, while those without the disease were seronegative blood donors.

Spinal antinociceptive effect of the PnTx4(5-5) peptide is possibly mediated by the NMDA autoreceptors.

Background: Medications currently used to treat pain are frequently associated with serious adverse effects and rapid development of tolerance. Thus, there is a need to develop more effective, and safer medicines for the population. Blocking NMDA receptors (NMDAR) has shown to be a promising target for the development of new drugs.

TiO nanotubes incorporated into a glaze-coating ceramic: surface roughness, color, and antibiofilm activity.

This study evaluated the surface roughness, color change, and antibacterial effect of a ceramic glaze enhanced with TiO nanotubes (n-TiO). n-TiO (0, 2, 2.5, and 5 wt%) was added to a ceramic glaze powder, applied to the surface of forty feldspathic ceramic specimens, and sintered.

The SARS-CoV-2 (COVID-19) pandemic and diagnosis and treatment of women with abnormal uterine bleeding: findings from Brazil.

Objective: To determine practice patterns in the diagnosis and management of nongestational abnormal uterine bleeding (AUB) in women in reproductive years during the SARS-CoV-2 (COVID-19) pandemic in Brazil.

Materials And Methods: A web-based survey was conducted to determine the impact of the COVID-19 pandemic on the diagnosis and management of women with AUB. Survey elements included treatment location, the use of ultrasonography, laboratory evaluation for iron deficiency and some hormone determinations, and endometrial evaluation by histopathology, as well as the practice of hysteroscopy, hysterectomy and medical therapy including the placement of the 52 mg levonorgestrel-intrauterine system (LNG-IUS).

Concordance Among In Vivo Reflectance Confocal Microscopy, Trichoscopy, and Histopathology in the Evaluation of Alopecia Areata Incognita.

Objectives: Alopecia areata incognita is a non-scarring autoimmune hair loss condition primarily affecting women aged 20 to 40. It is often misdiagnosed due to its resemblance to other conditions. Diagnosis relies on clinical suspicion, trichoscopic findings, and histological features.

Picloram drift in Peltophorum dubium, a species native to the Brazilian Cerrado.

Peltophorum dubium, a common tree in areas close to agricultural activity in the Brazilian Cerrado, is vulnerable to damage from the drift of picloram, an herbicide widely used in pastures and agriculture in Brazil. The aim was to evaluate the application of 0.0; 19.

Cholinergic modulation of upper airway control: maturational changes and mechanisms at cellular and synaptic levels.

Respiration is governed by a central rhythm and pattern generator, which has the pre-Bötzinger complex as the inspiratory oscillator initiating the coordinated activity of several respiratory muscles, including the diaphragm, intercostals, and upper airway muscles. The diaphragm is the main inspiratory pump muscle driving inflow, whereas dilator upper airway muscles, such as tongue muscles, reduce airway resistance during inspiration. Breathing exhibits a marked state-dependent pattern attributed to changes in neuromodulatory tone in respiratory-related brain regions, including decreases in noradrenaline and serotonin and increases in acetylcholine levels during rapid eye movement (REM) sleep.

Antimicrobial Resistance in spp. Isolated from Native Brazilian Fish Species: A Growing Challenge for Aquaculture.

spp. has emerged as a pathogen that is affecting global aquaculture, with , , and causing piscine lactococcosis. While antimicrobials are commonly used to treat diseases in aquaculture, reports of antimicrobial resistance in fish isolates are increasing.

Evaluation of the Psychometric Properties of the Digital Health Literacy Instrument (DHLI-BrA) for Use in Brazilian Adolescents.

This study evaluated the psychometric properties of the Portuguese version of Digital Health Literacy Instrument for Brazilian Adolescents (DHLI-BrA). Two hundred and sixty Brazilian adolescents answered the DHLI-BrA and the Brazilian version of quality-of-life and health literacy instruments: WHOQOL-Bref, eHEALS-BrA, NVS-BR, and REALMD-20. Then, they answered a questionnaire on sociodemographics, health, Internet access, and digital health aspects.

Assessment of the psychometric properties of the eHealth Literacy Scale for Brazilian adolescents.

With the increase in digitalization of adolescents and health services, the population must demonstrate digital health literacy skills to be able to navigate online health information, as well as identify, evaluate, and apply relevant information. The present study aimed to investigate the psychometric properties of the adapted version of the eHealth Literacy Scale (eHEALS-BrA) for Brazilian adolescents. This study was conducted between September 2022 and May 2023, involving a total of 260 adolescents aged 13 to 19, with a mean age of 15.

A Tropical Estuary Where Mercury Does Not Biomagnify and its Adjacent Waters that Render Extremely High Mercury Concentrations in Top Predators.

In general, mercury (Hg) undergoes biomagnification in aquatic systems. The absence of Hg biomagnification in a certain aquatic environment constitutes an exceptional finding and this seems to be the case for Sepetiba Bay, in Rio de Janeiro state (RJ), Brazil. There are three distinct ecological populations of Guiana dolphins in the Sepetiba Bay (SB)-Ilha Grande Bay (IGB) Complex, inhabiting: (1) the inner part of SB; (2) SB entrance; and (3) IGB.

Perception of Gratitude During an Online Mindfulness-Based Intervention (eMBI) in Patients with Interstitial Lung Disease in Brazil: An Exploratory Qualitative Study.

Interstitial lung diseases (ILDs) have an impact on patient quality of life at some point. Alternatives such as pulmonary rehabilitation, oxygen supplementation, yoga, and mindfulness practices can help in the care of patients with ILD. The current study was designed to explore the perceptions of gratitude by patients with various ILDs during an MBI.

Cystic Lesions and Odontogenic Tumors in Older People: A Brazilian Multicenter Study.

Background: Some odontogenic cysts (OCs) and odontogenic tumors (OTs) are infiltrative and often recur, causing bone destruction and tooth loss. In the elderly, in particular, these injuries cause significant morbidity, making rehabilitation difficult and compromising the quality of life of these individuals. Objective: To determine the prevalence and demographic characteristics of OCs, non-odontogenic cysts (NOCs), and OTs diagnosed in an elderly Brazilian population (≥60 years).