SKELETAL MUSCLE SENSITIVITY TO WASTING INDUCED BY UROTHELIAL CARCINOMA.

Background: Skeletal muscle wasting is a common phenotypic feature of several types of cancer, and it is associated with functional impairment, respiratory complications, and fatigue. However, equivocal evidence remains regarding the impact of cancer-induced muscle wasting on the different fiber types.

Aim: The aim of this study was to investigate the impact of urothelial carcinoma induced in mice on the histomorphometric features and collagen deposition in different skeletal muscles.

Individual and mutual effects of diabetes, hypertension, and obesity on acute respiratory distress syndrome mortality rates in clinical patients: a multicentre study.

Patients with comorbidities are more vulnerable to severe clinical cases of acute respiratory distress syndrome (ARDS) and COVID-19 require complex health care. To analyse the association between the individual and combined effects of diabetes, hypertension, and obesity on ARDS mortality rates among patients receiving clinical care. A multicentre study encompassing retrospective data analysis and conducted with 21,121 patients from 6,723 health services across Brazil, during the 2020-2022 time period.

Morphological anomalies in hard ticks (Acari: Ixodidae) from Brazil.

Tick abnormalities have been unusual in nature, and they can be divided into local and general. In the present study, external morphological anomalies were described in 31 individual adult ticks of 15 different species of Ixodidae, which were collected on wild hosts (20 ticks), domestic hosts (7 ticks), and in the environment (4 ticks) in 11 states of Brazil from 1998 to 2022. Among the 31 tick specimens, 14 (45%) were categorized as local anomalies, and 17 (55%) as general anomalies.

Maternal Th17 Profile after Zika Virus Infection Is Involved in Congenital Zika Syndrome Development in Children.

Brazil is one of the countries that experienced an epidemic of microcephaly and other congenital manifestations related to maternal Zika virus infection which can result in Congenital Zika Syndrome (CZS). Since the Zika virus can modulate the immune system, studying mothers' and children's immune profiles become essential to better understanding CZS development. Therefore, we investigated the lymphocyte population profile of children who developed CZS and their mothers' immune response in this study.

High Incidence of Respiratory Syncytial Virus in Children with Community-Acquired Pneumonia from a City in the Brazilian Pre-Amazon Region.

Introduction: Although fewer children have been affected by the severe form of the coronavirus disease 2019 (COVID-19), community-acquired pneumonia (CAP) continues to be the leading global cause of child hospitalizations and deaths.

Aim: This study investigated the incidence of respiratory syncytial virus (RSV) as well its subtypes (RSV A and B), adenovirus (ADV), rhinovirus (HRV), metapneumovirus (HMPV), coronavirus (NL63, OC43, 229E and HKU1), parainfluenza virus subtypes (PI1, PI2 and PI3), bocavirus and influenza A and B viruses (FluA and FluB) in children diagnosed with CAP during the COVID-19 pandemic.

Methods: A total of 200 children with clinically confirmed CAP were initially recruited, of whom 107 had negative qPCR results for SARS-CoV-2 and were included in this study.

Ensiling Sorghum with Urea, Aerobic Exposure and Effects on Intake, Digestibility, Ingestive Behaviour and Blood Parameters of Feedlot Lambs.

This study was carried out to evaluate the effect of ensiling sorghum silage with urea and amending the aerobic exposure nutrients intake and apparent digestibility, ingestive behaviour and blood serum metabolites of feedlot lambs. Forty uncastrated crossbred Dorper × Santa Inês lambs, aged 150 ± 15 days and with an initial body weight of 21.73 ± 2.

Environmental assessment of on-site source-separated wastewater treatment and reuse systems for resource recovery in a sustainable sanitation view.

Sustainable sanitation solutions are necessary for promoting public health and environmental security. In this study, on-site domestic wastewater treatment (WWT) systems used for households in rural and peri-urban areas of Brazil were compared in different scenarios from a life cycle assessment (LCA) perspective. The evaluated scenarios represented different practices in wastewater management, such as direct discharge into the soil, rudimentary treatment, septic tank, public sewerage system, and source separation of wastewater streams for water, nutrient, and organic matter recovery.

Nanosilica modulates C:N:P stoichiometry attenuating phosphorus toxicity more than deficiency in Megathyrsus maximus cultivated in an Oxisol and Entisol.

Silicon (Si) nanoparticles can attenuate nutritional disorders caused by phosphorus in forages through nutritional homeostasis. This paper aims to evaluate the effects of P deficiency and toxicity in Megathyrsus maximus cultivated in two types of soils and to verify whether Si application via fertigation can mitigate these imbalances. The following two experiments were carried out: cultivation of forage plants in pots with Entisol and Oxisol, in a 3 × 2 factorial design, with three nutritional levels of phosphorus (deficient, adequate, and excessive) and two Si concentrations in the irrigation water (0 and 1.

Field study of metal concentrations and biomarker responses in resident oysters of an estuarine system in southern Brazil.

Pollutant exposure is considered an important factor responsible for the decline in marine biodiversity of Latin American coastal ecosystems. This threat has been detected in an estuarine system in southern Brazil, which prompted an investigation into the long-term biological effects of a chronic metal contamination on resident oysters from the Laguna Estuarine System (LES). Here, we present the species- and size-specific variations of biomarker responses (catalase, glucose-6-phosphate dehydrogenase, glutathione S-transferase, and protein carbonylation) in the gills and digestive gland of Crassostrea gigas and Crassostrea gasar.

Delays in obtaining hospital care and abortion-related complications within a context of illegality.

Abortion, particularly when illegal, highlights inequities in different populations. Although abortion-related mortality is lower compared to other obstetric causes, abortion complications tend to be more lethal. Delays in seeking and obtaining care are determinants of negative outcomes.

Intake and serum levels of micronutrients and chronic oral diseases burden.

Objective: To investigate pathways from micronutrient intake and serum levels to Chronic Oral Diseases Burden.

Methods: We analyzed cross-sectional data from NHANES III (n = 7936) and NHANES 2011-2014 (n = 4929). The exposure was the intake and serum levels of vitamin D, calcium, and phosphorus.

Electrochemical sensor based on carbon nanotube decorated with manganese oxide nanoparticles for naphthalene determination.

In this work, an electrochemical sensor was developed for the determination of naphthalene (NaP) in well water samples, based on a glass carbon electrode (GCE) modified as a nanocomposite of manganese oxides (MnO) and COOH-functionalized multi-walled carbon nanotubes (MWCNT). The synthesis of MnO nanoparticles was performed by the sol-gel method. The nanocomposite was obtained by mixing MnO and MWCNT with the aid of ultrasound, followed by stirring for 24 h.

Canine and feline papillomaviruses: an update.

Papillomaviruses are small viruses able to cause disease not only in mammalians, but also in birds and reptiles. In recent years, a rising number of papillomaviruses have been identified in dogs and cats, totaling 24 canine papillomavirus (CPV) and six feline papillomavirus (FcaPV). The canine and feline papillomaviruses (CPVs and FcaPVs, respectively) are responsible for multiple lesions in these domestic species but the potential pathological relevance of some recently identified types remains to be determined.

Cytotoxic and Antileishmanial Effects of the Monoterpene β-Ocimene.

Leishmaniasis is a group of infectious-parasitic diseases with high mortality rates, and endemic in many regions of the globe. The currently available drugs present serious problems such as high toxicity, costs, and the emergence of drug resistance. This has stimulated research into new antileishmania drugs based on natural products and their derivatives.

The dissolved methane recovery from treated sewage in upflow anaerobic sludge blanket (UASB) reactors: The energy demand, carbon footprint and financial cost.

The goal of this research was to quantify the energy demand and carbon footprint over the life cycle, along with the financial cost, of sewage treatment with the recovery of dissolved methane (d-CH). The sewage treatment is composed of pre-treatment, followed by treatment in upflow anaerobic sludge blanket (UASB) reactors, trickling filter and secondary decanter, post-treatment with disinfection, and biogas recovery in the three-phase separator of the UASB reactor. The methods used in this study were attributional life cycle assessment and techno-economic analysis - LCA and TEA, respectively.

Methyl gallate nanomicelles impairs neutrophil accumulated in zymosan-induced arthritis.

Arthritis is a chronic disease that affects, approximately, 1 % of the total global population. It is characterized by chronic inflammation, accompanied in most of the cases of motor disability and sever pain. The main therapies available have high risk of failure and advanced treatments are scarce and highly cost.

Association between HLA Class II Alleles/Haplotypes and Genomic Ancestry in Brazilian Patients with Type 1 Diabetes: A Nationwide Exploratory Study.

We aimed to identify , , and alleles/haplotypes associated with European, African, or Native American genomic ancestry (GA) in admixed Brazilian patients with type 1 diabetes (T1D). This exploratory nationwide study enrolled 1599 participants. GA percentage was inferred using a panel of 46 ancestry informative marker-insertion/deletion.

The Impact of Radiolabeled Nanomaterials.

Nanotechnology has changed the world, with a great impact on industry and medicine. In this commentary, we discuss the importance of radiolabeled nanomaterials for the construction of theranostic, imaging and therapeutic agents in order to pave the future of medicine.

Thermal exchanges, physiological responses and productive performance of Guinea Fowl (Numidia meleagris) subjected to different air temperatures.

The objective of this research was to evaluate the thermal exchanges, physiological responses, productive performance and carcass yield of Guinea Fowl confined under thermoneutral conditions and under thermal stress. For the experiment, 96 animals were confined in 8 experimental boxes of 1 m of area, each, divided in equal numbers and placed inside two distinct climatic chambers, where the birds were distributed in a completely randomized design, with two treatments (air temperatures of 26 and 32 °C, respectively). For the collection of physiological responses and carcass yield 16 birds were evaluated and for the collection of data on feed and water consumption and productive responses, 48 birds per treatment were evaluated.

AgMoO·2HO nanorods under high pressure: In situ Raman spectroscopy.

This work presents a pressure-dependent behavior of silver trimolybdate dihydrate (AgMoO·2HO) nanorods using in situ Raman scattering. The AgMoO·2HO nanorods were obtained by the hydrothermal method at 140 °C for 6 h. The structural and morphological characterization of the sample was performed by powder X-ray diffraction (XRD) and scanning electron microscopy (SEM).

One-year follow-up of microscopical and clinical behavior of bioactive self-etching resin sealant.

Background: The development of early carious lesions can be prevented with the use of sealants. This study aimed to evaluate the retention and sealant quality of conventional and bioactive self-etching sealants by direct (clinical) and indirect (microscopical) assessment.

Materials And Methods: Sixty newly erupted mandibular second molars (International Caries Detection and Assessment System ≤2) from adolescents were selected for the split-mouth trial study.

Molecular characterization of Brazilian FeLV strains in São Luis, Maranhão Brazil.

The feline leukemia virus (FeLV) belongs to the Retroviridae family and Gammaretrovirus genus, and causes a variety of neoplastic and non-neoplastic diseases in domestic cats (Felis catus), such as thymic and multicentric lymphomas, myelodysplastic syndromes, acute myeloid leukemia, aplastic anemia, and immunodeficiency. The aim of the present study was to carry out the molecular characterization of FeLV-positive samples and determine the circulating viral subtype in the city of São Luís, Maranhão, Brazil, as well as identify its phylogenetic relationship and genetic diversity. The FIV Ac/FeLV Ag Test Kit (Alere™) and the commercial immunoenzymatic assay kit (Alere™) were used to detect the positive samples, which were subsequently confirmed by ELISA (ELISA - SNAP® Combo FeLV/FIV).

Immunomodulatory Activity of Probiotics in Models of Bacterial Infections.

As resistance to conventional antibiotics among bacteria continues to increase, researchers are increasingly focusing on alternative strategies for preventing and treating bacterial infections, one of which is microbiota modulation. The objective of this review is to analyze the scientific literature on the immunomodulatory effects of probiotics in bacterial infections. This is an integrative review of the literature based on systematic steps, with searches performed in the databases Medline, PubMed, Scopus, Embase, and ScienceDirect.