Machine Learning Assessment of Dredging Impacts on the Phytoplankton Community on the Brazilian Equatorial Margin: A Multivariate Analysis.

Dredging in estuarine systems significantly impacts phytoplankton communities, with suspended particulate matter (SPM) and dissolved aluminum (Al) serving as indicators of disturbance intensity. This study assessed the effects of dredging in the São Marcos Estuarine Complex (SMEC), Brazil, over three distinct events (2015, 2017, 2020), involving varying sediment volumes and climatic influences. Prolonged dredging operations and increased sediment volumes led to a pronounced 43.

Zein Nanoparticles-Loaded Flavonoids-Rich Fraction from : Potential Antileishmanial Applications.

Leishmaniasis, caused by protozoa of the genus , is a major global health issue due to the limitations of current treatments, which include low efficacy, high costs, and severe side effects. This study aimed to develop a more effective and less toxic therapy by utilizing zein nanoparticles (ZNPs) in combination with a nonpolar fraction (DCMF) from (Syn. ), a plant rich in dimeric flavonoids called brachydins.

Optical, Mechanical, and Chemical Impact of Brushing with Activated Charcoal Toothpowder and Toothpaste on Dental Enamel: An In Vitro Evaluation.

This in vitro study evaluated the effects of brushing with activated charcoal powder or toothpaste on enamel surface properties, including color change (ΔE), Knoop microhardness (HK), roughness (Ra), and the characteristics of the resulting brushing slurry [pH, fluoride (F), and calcium (Ca) concentration]. A total of 48 enamel samples were stained and divided into 4 groups ( = 12): activated charcoal toothpaste (AC-T), activated charcoal powder (AC-P), hydrogen peroxide-based whitening toothpaste (HP-T), and conventional toothpaste (C-T, positive control). The samples were subjected to a brushing cycling model, and ΔE, HK, Ra and enamel morphology were analyzed at baseline (T0) and after brushing cycle (T1).

A new coamorphous ethionamide with enhanced solubility: Preparation, characterization, in silico pharmacokinetics, and controlled release by encapsulation.

This study reports the synthesis and the experimental-theoretical characterization of a new coamorphous system consisting of ethionamide (ETH) and mandelic acid (MND) as a coformer. The solid dispersion was synthesized using the slow solvent evaporation method in an ethanolic medium. The structural, vibrational, and thermal properties of the system were characterized.

Bio-based plasticizer Babassu oil for custom-made conductive additive-manufacturing filaments: towards 3D-printed electrodes applied to cocaine detection.

Babassu (Atallea sp.), a native palm tree from South America's Amazon produces bio-oil and biochar with significant potential for industrial applications. Babassu oil as a bio-based plasticizer is reported here for the first time to replace petrochemical alternatives in the production of conductive filaments for additive manufacturing purposes.

Prevalence of depression and anxiety in women with chronic pelvic Pain: A systematic review and Meta-Analysis.

Purpose: This study aimed to present the prevalence of depression and anxiety in women with Chronic Pelvic Pain (CPP) and their associated factors.

Methods: This systematic review and meta-analysis were conducted using the PubMed, Embase, and SciELO platforms, focusing on studies published between 2010 and 2024.

Results: Eight studies were evaluated and demonstrated a significant prevalence of anxiety and depression in women with CPP, ranging from 22.

Pesticide contamination and associated ecological risks in estuarine waters of Brazil's Legal Amazon.

Pesticide contamination remains a significant environmental concern globally, with important implications for aquatic ecosystems. Despite being one of the world's largest pesticide consumers, monitoring and assessment of pesticide pollution are limited in Brazil, especially in sensitive regions like the Amazon. In this study, the occurrence and environmental risks of 8 pesticides of different classes, namely alachlor, atrazine, chlorfenvinphos, isoproturon, irgarol, simazine, diuron, and its transformation product DCPMU (1-(3,4-dichlorophenyl)-3-methyl urea) were analysed in surface water of the São Marcos Estuarine Complex (SMEC) in two consecutive years.

Higher levels of IL-6 and IL-10 cytokines in visceral leishmaniasis-HIV co-infected patients from Brazilian high endemic area.

Visceral Leishmaniasis (VL) is an endemic disease in Latin America, and the clinical outcome worsens when a patient has HIV co-infection. In these patients, the immune response is complex and cytokines profile variable. We evaluate Th1/Th2/Th17 cytokine profile in VL/HIV patients from Brazilian high endemic area.

Predictors of Hepatic Fibrosis in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.

Background/objectives: Approximately 25% of the world's population and more than 60% of patients with type 2 diabetes (T2D) have metabolic-dysfunction-associated steatotic liver disease (MASLD). The association between these pathologies is an important cause of morbidity and mortality in Brazil and worldwide due to the high frequency of advanced fibrosis and cirrhosis. The objective of this study was to determine the epidemiologic and clinical-laboratory profile of patients with T2D and MASLD treated at an endocrinology reference service in a state in northeastern Brazil, and to investigate the association of liver fibrosis with anthropometric and laboratory measurements.

Life cycle of Amblyomma calcaratum (Ixodida: Ixodidae) under laboratory conditions.

The life-cycle of Amblyomma calcaratum was evaluated experimentally under laboratory conditions using birds (Serinus canaria, Gallus gallus) and rodents (Calomys callosus) as hosts for immatures and a rabbit (Oryctolagus cuniculus) as host for adults. Developmental periods of the non-parasitic stages were observed in an incubator at 27 °C and 90% RH. The passerine S.

Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy.

As a multifactorial and heterogeneous disease, cancer has a high mortality rate, and the search for more effective treatments is an enormous challenge. Metal coordination compounds open a range of possibilities that conventional organic and biological molecules can no longer fulfil due to increasing drug resistance. Metallodrugs still have tremendous potential to help overcome drug resistance and find new cures in medicine, considering that at least 25 metallic elements participate in healthy functioning of the human body.

Clonal outbreak of Candida vulturna in a paediatric oncology ward in Maranhão, Brazil.

Objective: To describe an outbreak due to Candida vulturna, a newly emerging Candida species belonging to the Candida haemulonii species complex in the Metschnikowiaceae family.

Methods: In this retrospective cohort study we genotyped 14 C. vulturna bloodstream isolates, occurring in a 4-month-period in paediatric cancer patients in a Brazilian hospital.

Comprehensive analysis of the electronic, thermodynamic, and spectroscopic properties of a Cu(II)-based complex with 1,10-phenanthroline and L-glutamine.

This study reports additional information's of geometric, electronic, thermodynamic, and vibrational properties of a Cu(II) complex with 1,10-phenanthroline and L-glutamine ligands. The experimental spectroscopic analyses were corroborated by density functional theory (DFT). Furthermore, these properties were evaluated using an implicit solvation method with water and methanol solvents, including vacuum condition.

Exploring Thermal Stability, Vibrational Properties, and Biological Assessments of Dichloro(l-histidine)copper(II): A Combined Theoretical and Experimental Study.

Dichloro(l-histidine)copper(II) crystal ([Cu(l-His)Cl] complex) was obtained by the slow evaporation method and characterized concerning its thermal stability, phase transformations, and electronic and vibrational properties. X-ray diffraction (XRPD) confirmed that this complex crystallizes with an orthorhombic structure (222 space group). Thermal analyses (TG and DTA) demonstrate stability from ambient temperature up to 460 K, followed by a phase transition from the orthorhombic structure to the amorphous form around 465 K, as confirmed by temperature-dependent XRPD studies.

GSTM1 and GSTT1 deletions in penile cancer are associated with TNM stage but not with HPV DNA status.

Deletions of the GSTT1 and GSTM1 are associated with chemical carcinogenesis and genitourinary malignancies like bladder cancer, where they correlate with increased tumor aggressiveness. In uterine cervical lesions, GSTT1 and GSTM1 deletions have also been suggested to facilitate the persistence of human papillomavirus (HPV) infection and HPV-induced carcinogenesis. This work addresses the hypothesis that GSTT1/GSTM1 deletions are associated with presence of HPV DNA and aggressiveness in penile cancer, a rare malignancy with HPV+ and HPV- subtypes.

Syngas enhancement for Fischer-Tropsch integration via solid oxide electrolyzer cell co-electrolysis with or without methane.

The transition toward a sustainable energy framework requires developing innovative methods for fuel generation that utilize renewable resources and decrease carbon footprints. Thus, the review overviews current advancements in solid oxide electrolysis cell (SOEC) technology, specifically focusing on its application in co-electrolysis processes to produce syngas with different H:CO ratios, essential for Fischer-Tropsch synthesis. It emphasizes the potential of integrating partial methane oxidation reaction into the electrolysis process.

Media Representation of Scientists in Jornal Nacional: Reaffirmation of Stereotypes During the First Year of the COVID-19 Pandemic.

In response to the COVID-19 pandemic, scientific authorities were routinely consulted by mainstream media outlets through interviews, statements and/or supporting images. In this framework, our goal in this study was to analyze the media representation of scientists in Brazil during the first year of this global public health crisis. To this end, we applied a research protocol and, using statistical techniques, quantitatively analyzed newscasts on the country's main TV news program, Jornal Nacional.

Development of an Eco-Friendly Nanogel Incorporating Essential Oil as a Larvicidal Agent Against .

Background/objectives: Arboviruses, transmitted by mosquitoes like , pose significant public health challenges globally, particularly in tropical regions. The rapid spread and adaptation of viruses such as Dengue, Zika, and Chikungunya have emphasized the need for innovative control methods. Essential oils from plants, such as (Gardner) Sch.

The expression of and family genes in pituitary adenomas: clinical correlations and postsurgical outcomes.

Introduction: Pituitary adenomas (PAs) are benign tumors with high prevalence and, occasionally, aggressive course. The tumorigenesis of these lesions is not completely understood at the molecular level. BAK1 and BAX proteins play fundamental roles in apoptosis and seem to interact with VDAC proteins, whose expressions have been markedly altered in cancer, impacting their prognosis.

Evaluation of the Bioactive Compounds of Honey Obtained from the Açai () Floral Nectar.

The biodiversity of Brazil provides an excellent climate and favorable pollination conditions for L., especially in the Eastern Amazon region, which boasts vast floral wealth, including an abundance of açaí () flowers and fruits. In the present study, seven types of honey were evaluated: three containing floral nectar from açaí (Açaí honey) collected in the Eastern Amazon region (Açaí honey from Breu Branco (AH1 and AH2) and Açaí honey from Santa Maria (AH3), both from the state of Pará, Brazil) and four honeys from different regions of Brazil (Aroeira honey from Minas Gerais, Cipó-Uva honey from Distrito Federal, Mangue honey from Pará, and Timbó honey from Rio Grande do Sul).

Effects of mixed nuts as part of a Brazilian Cardioprotective diet on LDL-cholesterol in adult patients after myocardial infarction: a multicenter randomized controlled clinical trial.

Background: Nuts consumption is related to cardioprotective effects on primary cardiovascular prevention, but studies conducted in secondary prevention are small, scarce and controversial. The objective of this trial was to evaluate the effects of a regional and sustainable cardioprotective diet added or not with an affordable mixed nuts on cardiometabolic features in patients with previous myocardial infarction.

Methods: DICA-NUTS study is a national, multi-center, and superiority-parallel randomized clinical trial.

Impact of malocclusion and oral habits on oral health-related quality of life and sleep disturbance in young adults : A cross-sectional study.

Purpose: The aim of this study was to investigate the impact of malocclusion and oral habits on oral health-related quality of life and sleep disturbance in young adults.

Methods: A cross-sectional study was conducted with a sample of 213 young adults aged 18-30 years. Dental occlusion data were assessed through clinical examination.

Effects of Laser Acupuncture on Metabolic Functions of Sedentary People: A Double-Blind Randomized Clinical Trial.

Laser acupuncture regulates energy flow and restores body fluid metabolism. To evaluate the effects of the laser acupuncture protocol (LAP) on hepatic and renal metabolism in sedentary people. Longitudinal, double-blind, and randomized clinical trial with 29 participants, adults, both sexes, sedentary, without pre-existing metabolic diseases, subdivided into control and laser groups.

Tailoring 3D-printed sensor properties with reduced-graphene oxide: improved conductive filaments.

The development of a tailored filament is reported composed of reduced graphene oxide (rGO) and carbon black (CB) in a polylactic acid (PLA) matrix and its use in the production of electrochemical sensors. The electrodes containing rGO showed superior performance when compared with  those prepared in the absence of this material. Physicochemical and electrochemical characterizations of the electrodes showed the successful incorporation of both rGO and CB and an improved conductivity in the presence of rGO (lower resistance to charge transfer).