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B-cell epitopes of antigenic proteins in Leishmania infantum: an in silico analysis.
Parasite Immunol
July 2014
Graduate Program in Medicine and Health, Professor Edgard Santos University Hospital Complex, Federal University of Bahia (Universidade Federal da Bahia-UFBA), Salvador, Brazil; Academic Nursing Unit, Federal University of Campina Grande (Universidade Federal de Campina Grande)-UFCG, Cajazeiras, Brazil.
Serodiagnosis of visceral leishmaniasis is often hindered by cross-reactions to other parasitic diseases. Identifying specific B-cell epitopes in proteins is therefore important for immunodiagnostics, as well as for disease control by vaccines. This study aimed to identify linear and conformational B-cell epitopes and to evaluate the secondary structure of antigen proteins in Leishmania infantum using in silico analysis.
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