Impact of race and ethnicity on glaucoma progression detection by perimetry and optical coherence tomography.

This study assessed the impact of race and ethnicity on longitudinal test variability and time to detect glaucoma progression using standard automated perimetry (SAP) and optical coherence tomography (OCT). The sample consisted of 47,003 SAP tests from 5402 eyes and 25,480 OCT tests from 4125 eyes, with 20% of participants self-identifying as Black or African American and 80% as White; 29% as Hispanic or Latino and 71% as Not Hispanic or Latino. Variability was measured using standard deviations of residuals from linear regression models for SAP mean deviation (MD) and OCT retinal nerve fiber layer (RNFL) thickness over time.

Allelic variants in xenobiotic metabolism genes predict susceptibility and worse prognosis of urothelial bladder cancer.

Biomarkers that identify tumors with better/worse prognosis can help reduce treatment costs and contribute to patient survival. In urothelial bladder cancer (UBC), accurate prediction of recurrence and progression is essential to inform therapeutic management. Herein, we explore the role of genetic variants of xenobiotic metabolic pathways in UBC susceptibility and prognosis.

Analyses of the Genetic Diversity and Population Structures of spp. Clinical Isolates from Paraíba, Brazil.

Unlabelled: Sporotrichosis is a subcutaneous mycosis of global distribution, capable of affecting both humans and animals, and caused by species of the genus spp. This study aimed to evaluate the genetic diversity and mating type distribution of clinical isolates of human sporotrichosis in Paraíba, Brazil, to better understand the population structure, epidemiology, and diversification of this pathogen, as well as to explore possible transmission routes.

Methods: A total of 36 clinical isolates were morphologically identified, and clinical and demographic data were collected.

Association Between Visceral Fat and Lung Function Impairment in Overweight and Grade I Obese Women: A Cross-Sectional Study.

Beyond the common comorbidities related to obesity, such as type 2 diabetes and cardiovascular diseases, impaired lung function is already known, but whether the fat distribution (sub-cutaneous, visceral) affects the lung function and pulmonary immune response are poorly known. Few evidence has shown that visceral fat is associated with insulin resistance, low-grade inflammation, and reduced lung function. In the present study, the body composition and fat distribution were evaluated by multi-frequency octopolar bioimpedance.

Tau, amyloid, iron, oligodendrocytes ferroptosis, and inflammaging in the hippocampal formation of aged rats submitted to an aerobic exercise program.

Alzheimer's disease is a progressive neurodegenerative disease affecting memory, language, and thinking with no curative treatment. Symptoms appear gradually, and pathological brain changes may occur twenty years before the physical and psychological signs, pointing to the urgent development of preventive interventions. Physical activity has been investigated as a preventive tool to defeat the main biological features of AD: pathological amyloid protein plaques, tau tangles, myelin degeneration, and iron deposits in the brain.

Multicenter comparative analysis of local and aggregated data training strategies in COVID-19 outcome prediction with Machine learning.

Machine learning (ML) is a promising tool in assisting clinical decision-making for improving diagnosis and prognosis, especially in developing regions. It is often used with large samples, aggregating data from different regions and hospitals. However, it is unclear how this affects predictions in local centers.

Presentation and Analysis of the Online Evidence Gap Map, "Clinical Effectiveness of Homeopathy".

Introduction And Objective:  This study presents and analyzes the content of an online Evidence Gap Map (EGM), "", which graphically represents evidence from systematic reviews (SRs) of human clinical trials in homeopathy that were published from 1991 to 2021. The EGM was built according to the guidelines of the International Initiative for Impact Evaluation (3ie), adapted for complex interventions, to represent visually relevant evidence and research gaps.

Presentation Of Evidence Gap Map Content:  The interventions, classified as rows, are characterized in the EGM not only by the homeopathic therapeutic strategy but also by individual medicines and potencies.

Fish oil attenuates the expression of the CCL2 chemokine and histone-modifying enzymes in LPS-stimulated human preadipocytes.

In obesity, C-C chemokine ligand 2 (CCL2) plays a critical role in recruiting macrophages to white adipose tissue (WAT), contributing to chronic inflammation. In this study, we sought to explore the effects of fish oil (FO) on CCL2 expression and histone (H3K27)-modifying enzymes in both human model of preadipocytes and primary adipose-derived stem cells (ASCs). Present findings in preadipocytes lineage evidenced that lipopolysaccharide (LPS) increased (∼5.

Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery-a scoping review.

Introduction: The relationship between the Enhanced Recovery After Surgery (ERAS) guidelines and inflammatory markers in laparoscopic surgery has garnered increasing attention. These recommendations are designed to minimize surgical stress and potentially improve recovery outcomes by modifying perioperative care.

Objective: This scoping review aims to evaluate the impact of ERAS recommendations on inflammatory markers in patients undergoing laparoscopic surgeries, identifying current research gaps and consolidating findings from existing studies.

Impact of Congested Match Schedules on Countermovement Jump Metrics in Elite Volleyball Players.

Rebelo, A, Loturco, I, Pereira, JR, Martinho, DV, Valente-dos-Santos, J, and Broek, GV. Impact of congested match schedules on countermovement jump metrics in elite volleyball players. J Strength Cond Res XX(X): 000-000, 2024-The aim of this study was to assess the impact of a congested match schedule on various countermovement jump (CMJ) metrics recorded across the braking, transfer, propulsive, and flight phases of the CMJ.

Reasons for organ and tissue donation refusal and opposition: a scoping review.

Objective: To map the reasons why individuals oppose or refuse organ and tissue donation, from an international perspective.

Methods: A scoping review was conducted from May 2022 to February 2024 using a three-stage search strategy across five databases and Google Scholar. Data analysis involved categorizing information based on similarities and populations studied.

Injectable hydrogels for treating skin injuries in diabetic animal models: a systematic review.

Purpose: One of the main causes of chronic wounds is diabetes mellitus (DM), a metabolic disease characterized by chronic hyperglycemia. In this context, hydrogels have been used as a promising treatment for stimulating tissue ingrowth and healing in these injuries. This systematic review aimed to evaluate the findings of studies that investigated the effects of injectable hydrogels of various origins on skin wound healing using in vivo experimental models in diabetic rats.

Maternal separation stress increases alcohol preference regardless of DNA methylation and histone acetylation or methylation in the amygdala.

Alcohol use disorder (AUD) is a condition with multifactorial causes, including biopsychosocial factors. Childhood exposure to stress may increase susceptibility to AUD in adulthood. Despite its significance, the interaction between stress and AUD remains unclear.

Comparing Differences and Relationships Between Traditional and Resisted Sprints in Elite Youth Rugby Backs and Forwards.

Purpose: We tested the differences in maximum strength and various parameters of sprint performance between youth backs and forwards. Additionally, we examined the associations among various strength-sprint measures, as well as between unresisted and heavy resisted sprints.

Methods: Thirty-two youth rugby players were assessed at the beginning of the season with the following tests: unresisted and resisted (50% body mass) 30-m sprints and 1-repetition maximum (1RM) in the squat exercise.

Exploring the ventricular morphology of the heart of Brycon amazonicus (Agassiz, 1829) (Teleostei, Characiformes).

Brycon amazonicus, a fish species widely distributed along freshwater rivers in Latin America, is important in maintaining ecological balance. Although some morphological/physiological aspects of B. amazonicus have been reported, the cardiac histomorphology of this species remains poorly understood.

Morphogenesis and functional aspects of the muscular layer of the middle deep cervical fascia in humans.

Background: In recent years, the fasciae of the human body have received significant attention because of their crucial role in the transmission of muscle force. However, studies on the development of the fasciae, particularly the cervical fascia, remain scarce.

Purpose: This study was performed to examine the development of the fascia of the infrahyoid strap muscles, also known as the middle layer of the deep cervical fascia (MDCF), in 17 human embryos aged 6-8 weeks and 20 human foetuses aged 9-14 weeks.

Casting Skin Dressing Containing Extractions of the Organic Part of Marine Sponges for Wound Healing.

Skin wounds are extremely frequent injuries related to many etiologies. They are a burden on healthcare systems worldwide. Skin dressings are the most popular therapy, and collagen is the most commonly used biomaterial, although new sources of collagen have been studied, especially spongin-like from marine sponges (SPG), as a promising source due to a similar composition to vertebrates and the ability to function as a cell-matrix adhesion framework.

Analysis of the 10-day ultra-marathon using a predictive XG boost model.

Objective: Ultra-marathon running races are held as distance-limited or time-limited events, ranging from 6 h to 10 days. Only a few runners compete in 10-day events, and so far, we have little knowledge about the athletes' origins, performance, and event characteristics. The aim of the present study was to investigate the origin and performance of these runners and the fastest race locations.

Risk thresholds for the frequency of cannabis use during pregnancy and adverse neonatal outcomes: protocol for a systematic review and dose-response meta-analysis.

Background: Cannabis use during pregnancy has been increasing and is associated with adverse neonatal outcomes, such as low birth weight (LBW) and preterm birth (PTB). It remains largely unknown whether the association between cannabis use in pregnancy and increased risk of adverse neonatal outcomes is impacted by the frequency of cannabis use and whether thresholds exist below which risk is not significantly increased. The objective of this systematic review is to assess whether the association between cannabis use during pregnancy and the risk of adverse neonatal outcomes is dependent on the frequency of use and whether risk thresholds exist.

Exploring transparency: A comparative analysis of explainable artificial intelligence techniques in retinography images to support the diagnosis of glaucoma.

Machine learning models are widely applied across diverse fields, including nearly all segments of human activity. In healthcare, artificial intelligence techniques have revolutionized disease diagnosis, particularly in image classification. Although these models have achieved significant results, their lack of explainability has limited widespread adoption in clinical practice.

Responders COPD patients to two different home-based rehabilitation programs: a blind, randomized, and controlled clinical trial.

Purpose: To verify the number of patients with COPD responders to two different home-based rehabilitation programs.

Methods: This was a blinded, randomized, and controlled clinical trial. The six-minute step test (6MST), one-minute sit-stand test (1-MSTST), six-minute walk test (6MWT), COPD Assessment Test (CAT), modified Medical Research Council (mMRC), monitoring of physical activity in daily life, and isometric quadriceps muscle strength were assessed pre- and post-intervention.

Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein.

Virus-like particles (VLPs) are an established vaccine platform and can be strong immunogens capable of eliciting both humoral and cellular immune responses against a range of pathogens. Here, we show by cryo-electron microscopy that VLPs of Mayaro virus, which contain envelope glycoproteins E1-E2 and capsid, exhibit an architecture that closely resembles native virus. In contrast to monomeric and soluble envelope 2 (E2) glycoprotein, both VLPs as well as the adenovirus and modified vaccinia virus Ankara (MVA) vaccine platforms expressing the equivalent envelope glycoproteins E1-E2, and capsid induced highly neutralising antibodies after immunisation.