Amyloid-beta aggregation implicates multiple pathways in Alzheimer's disease: Understanding the mechanisms.

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by tau pathology and accumulations of neurofibrillary tangles (NFTs) along with amyloid-beta (Aβ). It has been associated with neuronal damage, synaptic dysfunction, and cognitive deficits. The current review explained the molecular mechanisms behind the implications of Aβ aggregation in AD multiple events.

Erythrocytic, Enzymatic, and Histological Markers of Oxidative Stress in Subacute and Chronic Stage Infections in Wistar Rats () Infected with .

Trypanosomiasis is a complex of diseases caused by a haemoprotozoan parasite of medical and veterinary importance. One of the leading factors that cause morbidity and death in trypanosomiasis is oxidative stress. The oxidative stress biomarkers in trypanosomiasis at the subacute and chronic stages of infection were investigated in this study.

Monitoring the Status of Soil-Transmitted Helminthiases in Non-Endemic Implementation Units: A Case Study of Borgu in Northcentral Nigeria.

Nigeria remains the most endemic country in sub-Saharan Africa (SSA) for soil-transmitted helminthiases (STH). In line with ongoing monitoring plans, we present findings from a recent analysis of STH epidemiological data in Borgu, one of the non-endemic implementation units for STH in the northcentral region of Nigeria. An overall prevalence of 8.

COVID-19 mortality rate and its associated factors during the first and second waves in Nigeria.

COVID-19 mortality rate has not been formally assessed in Nigeria. Thus, we aimed to address this gap and identify associated mortality risk factors during the first and second waves in Nigeria. This was a retrospective analysis of national surveillance data from all 37 States in Nigeria between February 27, 2020, and April 3, 2021.

Internet of Nano-Things (IoNT): A Comprehensive Review from Architecture to Security and Privacy Challenges.

Throughout the course of human history, owing to innovations that shape the future of mankind, many technologies have been innovated and used towards making people's lives easier. Such technologies have made us who we are today and are involved with every domain that is vital for human survival such as agriculture, healthcare, and transportation. The Internet of Things (IoT) is one such technology that revolutionizes almost every aspect of our lives, found early in the 21st century with the advancement of Internet and Information Communication (ICT) Technologies.

Lifetime prevalence and knowledge of snakebite among graduates in Nigeria.

Background: Given the lack of studies on snakebite envenoming knowledge in the general population, we examined the lifetime prevalence of snakebite and knowledge of snakebite and its prevention and first aid among recent Nigerian graduates in national service.

Methods: This questionnaire-based cross-sectional study involved 351 consenting national youth corps members at a rural orientation camp in Kano, Nigeria.

Results: Participants' mean age was 25.

Effects of supplementing organic- and inorganic-based selenium with vitamin E on intestinal histomorphology, caecal bacterial proliferation, and short-chain fatty acid profile in layer hens.

The effects of supplementing different dietary selenium (Se) sources on intestinal histomorphology, caecal bacterial proliferation, and caecum short-chain fatty acid in layer chickens were studied. A total of 120 of 54-week-old Lohman Brown Classic laying hens were subjected to four dietary treatments: control group with no Se supplementation (T1), 0.3 mg/kg of sodium selenite (T2), 0.

Multisectoral Perspectives on Global Warming and Vector-borne Diseases: a Focus on Southern Europe.

Purpose Of Review: The climate change (CC) or global warming (GW) modifies environment that favors vectors' abundance, growth, and reproduction, and consequently, the rate of development of pathogens within the vectors. This review highlights the threats of GW-induced vector-borne diseases (VBDs) in Southern Europe (SE) and the need for mitigation efforts to prevent potential global health catastrophe.

Recent Findings: Reports showed astronomical surges in the incidences of CC-induced VBDs in the SE.

Pre-clinical efficacy of African medicinal plants used in the treatment of snakebite envenoming: A systematic review.

The World Health Organization has listed Snakebite Envenoming (SBE) as a priority neglected tropical disease, with a worldwide annual snakebite affecting 5.4 million people and injuring 2.7 million lives.

Unravelling the dynamics of Lassa fever transmission with differential infectivity: Modeling analysis and control strategies.

Epidemic models have been broadly used to comprehend the dynamic behaviour of emerging and re-emerging infectious diseases, predict future trends, and assess intervention strategies. The symptomatic and asymptomatic features and environmental factors for Lassa fever (LF) transmission illustrate the need for sophisticated epidemic models to capture more vital dynamics and forecast trends of LF outbreaks within countries or sub-regions on various geographic scales. This study proposes a dynamic model to examine the transmission of LF infection, a deadly disease transmitted mainly by rodents through environment.

An integrated investigation of hydrocarbon pollution in Ahoada area, Niger Delta Region, Nigeria.

This study investigates hydrocarbon pollution in the Ahoada community of the Niger Delta region of Nigeria. The study uses a geographic information system (GIS) for mapping oil spill hotspots in the region. The resistivity method was used to delineate the extent of hydrocarbon pollution to a depth of 19.

Snakebite knowledge assessment and training of healthcare professionals in Asia, Africa, and the Middle East: A review.

Snakebite envenoming (SBE) is a common neglected tropical disease in rural communities of Asia, Africa and Latin America. Among the several challenges besetting the control of SBE is inadequate access to high-quality care by snakebite victims, partly contributed by inadequate knowledge of SBE among healthcare professionals (HCPs). This narrative review examined the existing literature on the knowledge of snakebites among HCPs, the factors associated with their knowledge of snakebites and their training needs.

Reversing Years for Global Food Security: A Review of the Food Security Situation in Sub-Saharan Africa (SSA).

All around the world, inequalities persist in the complex web of social, economic, and ecological factors that mediate food security outcomes at different human and institutional scales. There have been rapid and continuous improvements in agricultural productivity and better food security in many regions of the world during the past 50 years due to an expansion in crop area, irrigation, and supportive policy and institutional initiatives. However, in Sub-Saharan Africa, the situation is inverted.

Leaf Extract ameliorates oxidative stress and serum biochemical parameters in Streptozotocin-Induced diabetes in Wistar rats.

Introduction: : Diabetes Mellitus is a major health problem characterized by hyperglycemia and disturbances in metabolism and implicated in causing oxidative stress. Treatment includes administration of oral hypoglycaemic agents with lifestyle modifications, these offer glycemic control, however, present limitations about availability, affordability and side effects. Traditional anti-diabetic plants are becoming popular in management of diabetes mellitus.

Exposure to high thermal conditions for a long time induces apoptosis and decreases total RNA concentration in peripheral blood mononuclear cells among Indian Zebu-Jersey crossbreds.

Background And Aim: Global warming has grave consequences on livestock production systems and profound negative effects on animal production. This study aimed to carry out an thermal stress stimulation (TSS) of bovine peripheral blood mononuclear cells (PBMCs) using different thermal assault conditions (TACs), including normal to extreme temperatures and varying durations of thermal exposure (DTE) to understand how PBMCs of Indian Zebu-Jersey crossbreds respond to various levels and durations of heat shock.

Materials And Methods: Ten milliliters of blood were collected from 70 Indian Zebu-Jersey crossbreds under aseptic conditions and were sampled for isolating PBMCs.

Neural stem cell research in Africa: current realities and future prospects.

Neural stem cells (NSCs) are immature progenitor cells that are found in developing and adult brains that have the potential of dividing actively and renewing themselves, with a complex form of gene expression. The generation of new brain cells in adult individuals was initially considered impossible, however, the landmark discovery of human neural stem cells in the hippocampus has been followed by further discoveries in other discreet regions of the brain. Investigation into the current state in Africa of the research and use of NSCs shows relatively limited activities on the continent.

Non-COVID-19 uptake of personal protective equipment and rules compliance amongst industrial workers in Kano, Nigeria.

Background: Every workplace has got hazards in many different forms, ranging from sharps, falling objects, chemicals, infections, noise and a lot of other potentially dangerous situations. The occupational safety and health administration mandates employers to protect their employees from such potentially dangerous workplace hazards. Personal protective equipment (PPE) plays an important role in preventing and ensuring health safety amongst industrial workers.

Neurobehavioral and Immunohistochemical Studies of the Cerebral Cortex Following Treatment with Ethyl Acetate Leaf Fraction of During Prenatal Aluminum Chloride Exposure in Wistar Rats.

Purpose: The recent increase in aluminum exposure and its effect on the development of the brain call for serious attention. The study investigated the behavioral and immunohistochemical changes in the cerebral cortex of Wistar rats following prenatal co-administration of ethyl acetate leaf fraction of (EATI) and aluminum chloride (AlCl).

Methods: Pregnant Wistar rats were divided into 5 groups (n=4).

Sub-acute toxicity study on hydromethanolic leaves extract of (Combretaceae) Diels in Wistar rats.

The plant Diels (Combretaceae) has been utilized in Nigeria and other African nations to treat many diseases including liver, inflammatory, gastrointestinal, respiratory, infectious diseases, epilepsy and many more. Pharmacological investigations have shown that the plant possesses anti-infective, antidiarrhoeal, hepatoprotective, anti-inflammatory, anticancer, sedative, antioxidant, and antiepileptic potentials. However, information on its toxicity profile is unavailable despite the plant's therapeutic potential.

Fermented soybean meal modified the rumen microbiome to enhance the yield of milk components in Holstein cows.

The study was conducted to evaluate the rumen microbiota as well as the milk composition and milk component yields of Holstein cows supplemented with fermented soybean meal (FSBM). Eighteen Holstein cows in their 2nd parity with 54.38 ± 11.

Educational quality and technological complexity on recognition of enhanced learning platform in developing countries using PLS-SEM in a post COVID era.

The e-learning platform provides a new teaching-learning channel in which instructors provide information to learners irrespective of method used to access the platform. The purpose of this study is to examine instructors' acceptance of e-learning in Nigerian universities. The study adopted a quantitative approach, with a total of 299 questionnaires collected from instructors.

Prevalence and Associated Risk Factors of Urinary Schistosomiasis among Primary School Pupils in the Jidawa and Zobiya Communities of Jigawa State, Nigeria.

Background: Urogenital schistosomiasis (UgS) is a parasitic disease caused by and can lead to chronic ill-health. Nigeria is endemic for schistosomiasis, but epidemiology of UgS has not been studied in most states. This study was conceived with the aim to contribute towards an accurate national picture of UgS in Nigeria.

Adsorption Behavior of Methylene Blue Cationic Dye in Aqueous Solution Using Polypyrrole-Polyethylenimine Nano-Adsorbent.

In this work, a polypyrrole-polyethyleneimine (PPy-PEI) nano-adsorbent was successfully synthesized for the removal of methylene blue (MB) from an aqueous solution. Synthetic dyes are among the most prevalent environmental contaminants. A new conducting polymer-based adsorbent called (PPy-PEI) was successfully produced using ammonium persulfate as an oxidant.

ameliorates behavioral and cytoarchitectural changes in the cerebellar cortex following prenatal aluminum chloride exposure in Wistar rats.

Aluminium exposure has been linked with developmental neurotoxicity in humans and experimental animals. The study aimed to evaluate the ameliorative effect of Tamarindus indica on the developing cerebellar cortex, neurobehavior, and immunohistochemistry of the cerebellar cortex following prenatal aluminum chloride (AlCl) exposure. Pregnant timed Wistar rats were divided into 5 groups (n=4).