321 results match your criteria: "Federal Technological University of Parana[Affiliation]"

Preclinical tests for salicylhydrazones derivatives to explore their potential for new antituberculosis agents.

Tuberculosis (Edinb)

September 2024

Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, 87020-900, Brazil; Laboratory of Medical Bacteriology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil. Electronic address:

Article Synopsis
  • This study focused on synthesizing 22 salicylhydrazone derivatives to test their effectiveness as new anti-TB drugs in vitro.
  • Three compounds (10, 11, and 18) were highlighted for their promising results, with compound 18 showcasing the best activity against Mycobacterium tuberculosis at a low MIC of 0.49 μg/mL and good safety profile.
  • The compounds exhibited cooperative effects when tested with existing TB drugs and showed potential against both drug-susceptible and resistant strains, particularly compound 18 which stood out due to its low cytotoxicity.
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Objective: Apply Graph Theory to analyze and map knowledge about nursing diagnoses and interventions, based on records of consultations carried out by nurses, in women's health, in primary health care.

Methods: Secondary data from a cross-sectional study were used. Records of nursing consultations carried out during the month of October 2016, in 21 health units, in a Brazilian municipality were analyzed.

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. The main objective of this study was to evaluate mean propulsive velocity (MPV), mean propulsive force (MPF) and mean propulsive power (MPP) in elite police officers under LOADED and UNLOADED conditions. The study also investigated the association of body composition and strength levels under the same load conditions.

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Effects of blood metal(loid) concentrations on genomic damages in sharks.

Environ Pollut

October 2024

Evolutionary and Environmental Genomics Laboratory, Federal Technological University of Paraná, Av. dos Pioneiros, 3131, Jardim Morumbi, 86036-370, Londrina, Paraná, Brazil. Electronic address:

The use of effect biomarkers has contributed to the understanding of the sublethal effects of contaminants on different organisms. However, the analysis of genotoxic markers as an indicator of organism and environmental health in sharks is underexplored. Thus, the present study investigated the relationship between the genomic damage frequency in erythrocytes and metal(loid) concentrations in whole blood of three shark species (Galeocerdo cuvier, Negaprion brevirostris and Ginglymostoma cirratum), taking into account climatic seasonality.

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control methods have proved to be inefficient, which justifies the search for new control measures. In this search for botanical insecticides for controlling , the following were evaluated: (i) the toxicity of essential oils (EOs) from , , and ; (ii) the effect of EOs on life table parameters against ; (iii) the chemical characterization of EOs; and (iv) the in silico interaction of the chemical constituents present in the three EOs with the molecular targets of . The EO from had the lowest LD (1.

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Pfaffia glomerata (Spreng.) Pedersen has among its main bioactive compounds saponins, with the phytoestroid β-ecdysone as its chemical marker. In this study, pressurized liquid extraction (PLE), a green extraction technique used to obtain bioactive compounds from plants, was employed to extract beta-ecdysone from P.

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The Impact of Polyphosphates on the Colloidal Stability of Laponite Particles.

J Phys Chem B

July 2024

MTA-SZTE Momentum Biocolloids Research Group, Department of Physical Chemistry and Materials Science, Interdisciplinary Centre of Excellence, University of Szeged, 6720 Szeged, Hungary.

The effect of polyphosphate (polyP) adsorption on the colloidal properties of disc-shaped laponite (LRD) particles was examined in aqueous dispersions with a focus on elucidating the interparticle forces that govern the colloidal stability of the systems. The charge and aggregation rate data of bare LRD exhibited an ionic strength-dependent trend, confirming the presence of double-layer repulsion and van der Waals attraction as major surface interactions. The charge of LRD particles significantly increased in magnitude at elevated polyP concentrations as a result of polyP adsorption and subsequent overcharging of the positively charged sites on the edges of the LRD discs.

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Propylparaben (PrP) and dichloropropylparaben (diClPrP) are found in soil worldwide, mainly due to the incorporation of urban sludge in crop soils and the use of non-raw wastewater for irrigation. Studies on the adverse effects of PrP on plants are incipient and not found for diClPrP. PrP and diClPrP were evaluated at concentrations 4, 40, and 400 µg/L for their phytotoxic potential to seeds of Allium cepa (onion), Cucumis sativus (cucumber), Lycopersicum sculentum (tomato), and Lactuca sativa (lettuce), and cytotoxic, genotoxic potential, and for generating oxygen-reactive substances in root meristems of A.

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Avobenzone (AVO) is a sunscreen with high global production and is constantly released into the environment. Incorporating sewage biosolids for fertilization purposes, the leaching from cultivated soils, and the use of wastewater for irrigation explain its presence in the soil. There is a lack of information about the impact of this sunscreen on plants.

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Formulation and Characterization of Nanoemulsion Incorporating L. Extract Stabilized with Hyaluronic Acid.

Pharmaceutics

May 2024

Graduate Program in Medicinal Plants and Herbal Medicines in Basic Health Care, Universidade Paranaense (UNIPAR), Umuarama 87502-210, Brazil.

Skin lesions are an important health concern, exposing the body to infection risks. Utilizing natural products containing chamomile ( L.) holds promise for curative purposes.

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Research into microbial interactions during coffee processing is essential for developing new methods that adapt to climate change and improve flavor, thus enhancing the resilience and quality of global coffee production. This study aimed to investigate how microbial communities interact and contribute to flavor development in coffee processing within humid subtropical climates. Employing Illumina sequencing for microbial dynamics analysis, and high-performance liquid chromatography (HPLC) integrated with gas chromatography-mass spectrometry (GC-MS) for metabolite assessment, the study revealed intricate microbial diversity and associated metabolic activities.

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Cardiovascular diseases are considered the leading cause of mortality globally; even with low mortality in dogs, such diseases are described in the same way in companion animals and humans. This study aimed to devise an effective decellularization protocol for the canine myocardium through the association of physical, chemical, and enzymatic methods, assessing resultant alterations in the myocardial extracellular matrix to obtain a suitable scaffold. Two canine hearts were collected; the samples were sectioned into ±1 cm fragments, washed in distilled water and 1× PBS solution, and followed by treatment under four distinct decellularization protocols.

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Despite being composed of recyclable materials, the main technological challenge of multilayer carton packs involves the efficient decompatibilization of the cellulosic, polymeric, and metallic phases. Here, a simple two-step mechanochemical process is described that uses only aqueous media and mechanical force to promote phase separation in order to fully recycle multi-layer carton packaging. The first step produces value-added micro- and nanocellulose, while in the second step, aluminum is extracted, forming precipitated aluminum and aluminum oxyhydroxides.

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Objectives: Firefighters work with dogs as support for their search activities for victims. Firefighters who handle dogs supposedly have higher acute muscle pain, more stumbling, and fatigue. This study aimed to verify the influence of a mantrailing dog on the firefighter's psychophysiological and muscular responses and the number of imbalances in a simulated activity of searching for people.

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Background: Surveys conducted in different regions of the world show that the prevalence rates of health risk behaviors (HRBs) in university students are sometimes higher than those found in non-university populations. This study aims to identify the prevalence rates and demographic and academic environment correlates associated with HRBs among Brazilian university students.

Methods: In a cross-sectional epidemiological study, a random sample of 5310 university students answered an online questionnaire, with demographic (sex, age, skin color, marital status, and paid work) and academic setting information (housing type, size of campus, year, and shift of study), as well as items clustered in four HRB domains: personal safety and violence, sexual behavior and contraception, addictive substance use, eating habits, physical activity, and sleep.

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Finite element analysis (FEA) has been used to analyze the behavior of dental materials, mainly in implantology. However, FEA is a mechanical analysis and few studies have tried to simulate the biological characteristics of the healing process of loaded implants. This study used the rule of mixtures to simulate the biological healing process of immediate implants in an alveolus socket and bone-implant junction interface through FEA.

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The quality of welds is critical to the safety of structures in construction, so early detection of irregularities is crucial. Advances in machine vision inspection technologies, such as deep learning models, have improved the detection of weld defects. This paper presents a new CNN model based on ResNet50 to classify four types of weld defects in radiographic images: crack, pore, non-penetration, and no defect.

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Article Synopsis
  • * Four samples were created: GS alone, Kao, RC, and a mix of all three in a specific ratio, then subjected to heat treatment at varying temperatures (950°C and 1200°C) to test their strength and composition.
  • * Results showed that heat treatment at 1200°C allowed for the encapsulation of heavy metals into stable compounds, indicating that using GS with clay in ceramics is a sustainable practice that can reduce the need for traditional clay sources.
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The decision to implement a biogas production project involves the evaluation of multiple variables, such as the problem to be solved, the biodigester, business model, investment, and final products. An integrative literature review was conducted, in which 58 papers were obtained and relevant criteria for decision-making in biogas production projects from organic waste were identified. Three stages were considered in the analysis of the biogas production cycle: initial, plant, and final, as well as the economic, environmental, and social aspects that influence the decision.

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Viral respiratory infections represent a major threat to the population's health globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 disease and in some cases the symptoms can be confused with Influenza disease caused by the Influenza A viruses. A simple, fast, and selective assay capable of identifying the etiological agent and differentiating the diseases is essential to provide the correct clinical management to the patient.

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Mono- and diglycerides play a crucial role in the food industry as multifunctional food additives and emulsifiers. Their importance stems from their unique properties, which allow them to improve the quality, texture, and stability of various food products. Here, results of the kinetic modeling of the mono- and diglycerides synthesis mediated by the lipase Lipozyme® TL 100 L immobilized on the clayey support Spectrogel® type C are reported.

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Chemical profile and biological properties of the C.DC. essential oil.

Saudi Pharm J

March 2024

Department of Chemistry, Postgraduate Program in Chemical and Biochemical Process Technology (PPGTP), Federal Technological University of Paraná, Campus Pato Branco, PO Box 571, CEP 85503-390 PR, Brazil.

Article Synopsis
  • The essential oil from Piper corcovadense, a plant native to northern Brazil, was chemically analyzed and shown to possess significant antioxidant and antimicrobial properties.
  • Key compounds identified included trans-sesquisabinene hydrate and trans-caryophyllene, which contributed to its effectiveness against bacteria and potential antitumor activity.
  • The oil reduced cell viability in cutaneous melanoma cells without harming healthy blood cells, indicating its therapeutic potential against cancer while being safe for normal cells.
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Italian ryegrass (Lolium multiflorum L.) is an invasive species widely spread in croplands worldwide. The intensive use of glyphosate has resulted in the selection of resistance to this herbicide in Italian ryegrass.

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In the food industry, the microencapsulation process is important to control the release of active encapsulated ingredients, mask unwanted flavors, colors, and unpleasant smells, increase shelf life, and protect encapsulated components from light, moisture, and nutritional loss. In this process, microspheres are formed using cross-linked polymer, which can incorporate aqueous or oily ingredients, using simple physicochemical methods of phase separation by coacervation, without the need for organic solvents. In this context, this study aimed to develop bioactive, functional frozen yogurt through the incorporation of microspheres loaded with ascorbic acid or omega 3.

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