3 results match your criteria: "Federal Research and Clinical Center of Reanimatology and Rehabilitology[Affiliation]"
High dose esomeprazole as an anti-inflammatory agent in sepsis: Protocol for a randomized controlled trial.
Contemp Clin Trials
October 2023
IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
Article Synopsis
- Sepsis is a severe condition caused by an uncontrolled immune response to infection, which often leads to high mortality and limited treatment options beyond antibiotics.
- Recent research indicates that high doses of proton pump inhibitors like esomeprazole could potentially help regulate immune reactions in sepsis patients, improving their clinical outcomes.
- The PPI-SEPSIS trial will test this hypothesis by comparing high-dose esomeprazole to a placebo in 300 critically ill patients, focusing on its effect on organ dysfunction and other health metrics over 10 days.
Effects of early postoperative neurocognitive disorders on clinically relevant outcomes: a meta-analysis.
Korean J Anesthesiol
October 2023
Department of Intensive Care Medicine, Federal Research and Clinical Center of Reanimatology and Rehabilitology, Moscow, Russia.
Background: Early postoperative neurocognitive disorders (ePND), include both emergence delirium, which is defined as very early onset postoperative delirium, and emergence agitation, defined as motor arousal. Although research on anesthesia emergence is limited, ePND are likely associated with unfavorable outcomes. This meta-analysis assessed the effect of ePND on clinically relevant outcomes.
View Article and Find Full Text PDFMitochondrial diseases caused by mtDNA mutations: a mini-review.
Ther Clin Risk Manag
October 2018
Department of Genetics, Southern Federal University, Rostov-on-Don, Russian Federation.
There are several types of mitochondrial cytopathies, which cause a set of disorders, arise as a result of mitochondria's failure. Mitochondria's functional disruption leads to development of physical, growing and cognitive disabilities and includes multiple organ pathologies, essentially disturbing the nervous and muscular systems. The origins of mitochondrial cytopathies are mutations in genes of nuclear DNA encoding mitochondrial proteins or in mitochondrial DNA.
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