2 results match your criteria: "Federal Research Center of Fundamental and Translational Medicine SB RAS[Affiliation]"
Investigation of cytotoxic and antioxidative activity of 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins.
Protoplasma
September 2022
Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.
Article Synopsis
- High biological activity of natural furocoumarins can lead to harmful side effects, like genotoxicity, making it important to develop safer semi-synthetic alternatives.
- The researchers previously examined twenty-one modified furocoumarins to find alterations that reduce negative effects while keeping or improving their beneficial properties.
- In this article, they focus on assessing the cytotoxic activity of these compounds, ranking them by severity, and using statistical analysis to identify the best modifications for future development.
Genotoxic activity of 1,2,3-triazolyl modified furocoumarins and 2,3-dihydrofurocoumarins.
J Biochem Mol Toxicol
November 2019
Federal Research Center of Fundamental and Translational Medicine SB RAS, Novosibirsk, Russia.
The furocoumarin backbone is a promising platform for chemical modifications aimed at creating new pharmaceutical agents. However, the high level of biological activity of furocoumarins is associated with a number of negative effects. For example, some of the naturally occurring ones and their derivatives can show genotoxic and mutagenic properties as a result of their forming crosslinks with DNA molecules.
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