6 results match your criteria: "Federal Research Center Komi Scientific Centre[Affiliation]"
Polyphenols as Potential Geroprotectors.
Antioxid Redox Signal
March 2024
Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology of the Federal Research Center "Komi Scientific Centre" of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.
Currently, a large amount of evidence of beneficial effects of diets enriched with polyphenols on various aspects of health has been accumulated. These phytochemicals have a geroprotective potential slowing down the pathological processes associated with aging and ensuring longevity. In this study, a comprehensive analysis was conducted to determine the adherence of individual polyphenols to geroprotector criteria.
View Article and Find Full Text PDFIncreasing the Efficacy of Treatment of - Mixed Infections with Myrtenol.
Antibiotics (Basel)
December 2022
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Infectious diseases caused by various nosocomial microorganisms affect worldwide both immunocompromised and relatively healthy persons. Bacteria and fungi have different tools to evade antimicrobials, such as hydrolysis damaging the drug, efflux systems, and the formation of biofilm that significantly complicates the treatment of the infection. Here, we show that myrtenol potentiates the antimicrobial and biofilm-preventing activity of conventional drugs against and mono- and dual-species cultures.
View Article and Find Full Text PDFDesign, Spectral Characteristics, and Possibilities for Practical Application of BODIPY FL-Labeled Monoterpenoid.
ACS Appl Bio Mater
August 2021
Kazan Federal University, 420008 Kazan, Russian Federation.
Article Synopsis
- The article discusses the design and biological properties of a fluorescent compound called BODIPYmyrt, which is made from a specific monoterpenoid and a fluorophore.
- BODIPYmyrt has a high quantum yield (close to 100%) in the 515-518 nm range, indicating its effectiveness in fluorescence applications.
- It can penetrate bacterial and fungal cell membranes, making it useful for studying various types of bacteria and fungi, and also shows potential for targeting subcellular structures like mitochondria in mammalian cells.
Conjugate of meso-carboxysubstituted-BODIPY with thioterpenoid as an effective fluorescent probe: Synthesis, structure, spectral characteristics, and molecular docking.
Spectrochim Acta A Mol Biomol Spectrosc
March 2022
Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia.
Article Synopsis
- - This paper focuses on creating a fluorescent probe using meso-carboxysubstituted-BODIPY combined with a thioterpene fragment to examine the antiplatelet and anticoagulant effects of thioterpenoids.
- - The researchers replaced a methoxy group in the BODIPY molecule with the thioterpene fragment to better understand the interactions of these compounds with membranes and receptors.
- - The newly designed probe exhibits a high fluorescence quantum yield near 100% in the blue-green range (509-516 nm) and shows improved affinity to the platelet receptor P2Y through molecular docking studies.
2,6-Diisobornyl-4-Methylphenol Reduces Postishemic Myocardium Remodeling in Delayed Period after Ischemia/Reperfusion in Rats.
Bull Exp Biol Med
July 2020
Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
2,6-Diisobornyl-4-methylphenol (Dibornol, 10 mg/kg intragastrically daily for 5 days after myocardial ischemia/reperfusion) 1.5-fold increased rat survival during the acute post-infarction period in comparison with the control group. In survivors, Dibornol reliably prevented post-ischemic progression of heart failure in the delayed post-infarction period (30 days after ischemia/reperfusion), which was seen from an increase in the left-ventricular developed pressure by 22%, left-ventricular contractility index by 19%, and +dP/dt by 34%.
View Article and Find Full Text PDFPreventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia.
Bull Exp Biol Med
July 2020
Institute of Physiology, Federal Research Center Komi Scientific Centre, Ural Division of Russian Academy of Sciences, Moscow, Russia.
The effect of preventive administration of melatonin on the arrhythmogenic substrate in the myocardium was studied in the rabbit model of acute ischemia/reperfusion in vivo. The animals treated with melatonin 60 min before ischemia induction had shorter median activation time compared to the control group (p=0.039), less pronounced shortening of repolarization durations in the ischemic zone during coronary occlusion (p=0.
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