Skin Tear Treatment with Hayne in Polymeric Hydrogel: A Randomized Clinical Trial.

A double-blind, randomized, and controlled clinical trial with therapeutic intervention was performed at a university hospital in Rio de Janeiro to evaluate whether the addition of Hayne oleoresin to a carboxypolymethylene hydrogel is more effective in skin tear healing than standard treatment. The sample consisted of 84 patients, predominantly men, with a mean age of 67.37 years.

Assessment of the effects of harvesting period of Clusia fluminensis Planch & Triana fruits on neutralization of the toxic activities of Bothrops jararacussu snake venom.

Snakebite envenomation is a public health issue that can lead to mortality and physical consequences. It is estimated that 5.4 million venomous snake bites occur annually, with 130,000 deaths and 400,000 amputations.

Abiotic Factors Modulating Metabolite Composition in Brown Algae (Phaeophyceae): Ecological Impacts and Opportunities for Bioprospecting of Bioactive Compounds.

Brown algae are vital structural elements and contributors to biodiversity in marine ecosystems. These organisms adapt to various environmental challenges by producing primary and secondary metabolites crucial for their survival, defense, and resilience. Besides their ecological role, these diverse metabolites have potential for biotechnological applications in industries including pharmaceuticals, cosmetics, and food.

Diversity of Endodontic Enterococcus faecalis from Brazil with a High Occurrence of the ST 397 Clone.

Enterococcus faecalis is a common cause of nosocomial infections and is frequently associated with endodontic infections. However, there is a scarcity of studies addressing the genetic characterization of E. faecalis lineages most commonly associated with root canals.

Cinnamon powder intake enhances the effect of caloric restriction on white adipose tissue in male rats.

Caloric Restriction (CR) and cinnamon promote several benefits, including the modulation of lipid metabolism and body fat mass. We hypothesize that cinnamon may act as a mimetic of restriction or enhance the effects of caloric restriction on adipose tissue. Adult male Wistar rats were divided into Control (CT, n = 8) and Cinnamon (CIN, n = 7), with free access to standard chow; Calorie Restriction (CR, n = 8) and Calorie Restriction with Cinnamon (CIN-CR, n = 7), subjected to a 30% reduction in food intake compared to the average consumption of CT rats.

Genotoxicity analysis of a flame retardant, aluminum diethylphosphinate.

Flame retardants, crucial for fire prevention, are used worldwide, but they are considered to be 'emerging contaminants' and may pose risks to human and environmental health. Aluminum diethyl phosphinate (ALPI) is a halogen-free flame retardant. To evaluate the toxicity of this compound, the following assays were performed: Salmonella/microsome mutagenicity assay; toxicity assays with two endpoints (mitochondrial dehydrogenase activity, plasma membrane integrity); micronucleus assay with human hepatoma cell line HepG2.

Radiometric evaluation of Ouratea miersii (Planch.) Engl. From the Municipal Natural Park of Niterói, Brazilian Atlantic Rainforest remnant.

Concern about radiation exposure to non-human biota and the environment has increased since the 1990s, resulting in several publications by UNSCEAR, IAEA, ICRP, among other agencies, which highlighted significant gaps in knowledge regarding non-human biota and resulted in the establishment of Reference Animals and Plants (RAPs). In Brazil, the Atlantic Forest biome has vast biodiversity, but there is a lack of information on the radiometric profile of plant species growing there. Thus, the objective of this study was to evaluate the radiometric profile of Ouratea miersii (Malpighiales), endemic to the Atlantic Rainforest, collected in the State of Rio de Janeiro, city of Niterói, at the Municipal Natural Park (PARNIT), which covers a region of protected Atlantic Rainforest.

New Epitopes for the Serodiagnosis of Human Borreliosis.

Lyme disease, a zoonotic infection caused by the bacterium , is transmitted to humans through the bites of infected ticks. Its diagnosis primarily relies on serological methods; however, the existing borreliosis techniques have shown a variable sensitivity and specificity. Our study aimed to map IgG epitopes from five outer membrane proteins (Omp) from [Filament flagellar 41kD (PI1089), flagellar hook-associated protein (Q44767), Flagellar hook k2 protein (O51173), Putative Omp BURGA03 (Q44849), and 31 kDa OspA (P0CL66)] lipoprotein to find specific epitopes for the development of accurate diagnosis methods.

assessment of the antioxidant potential in UVA-induced phototoxicity.

Photoaging induced by ultraviolet A (UVA) radiation is mainly caused by the reactive oxygen species (ROS) increase, which trigger undesirable changes in the skin, such as inflammatory reactions, wrinkles, hyperpigmentation, and loss of elasticity. In this context, plant ingredients have been highlighted in recent decades due to their antioxidant mechanisms. This study investigated the potential of ethanolic extract against UVA-induced damage in 3T3 fibroblasts.

Detecting Leptospira spp. infection in cows by PCR: What is the best sample to test?

Bovine leptospirosis is a major reproductive disease. As cows can be leptospiral carriers both on the renal and genital tract, diagnosis can be challenging, with an underlying risk of misdiagnosis. Traditionally, the infection has been diagnosed by culturing or PCR from urine samples.

"How-to": scoping review?

Background And Objective: Scoping reviews are a type of evidence synthesis that aims to identify and map the breadth of evidence available on a particular topic, field, concept, or issue, within or across a defined context or contexts. Scoping reviews can contribute to clinical practice guideline development, policy making, reduce research waste by eliminating duplication of research effort, and be a precursor to a systematic review or inform further primary research. This article aims to provide a brief introduction of how to conduct and report scoping reviews.

Efficacy and safety of trifluridine/tipiracil plus bevacizumab across different subgroups of patients with refractory colorectal cancer: a meta-analysis.

Introduction: Metastatic colorectal cancer (mCRC) patients who are refractory to initial treatment lines exhibit a challenging clinical scenario characterised by a poor prognosis and constrained therapeutic options. This systematic review and meta-analysis assess the integration of bevacizumab into trifluridine-tipiracil (TFD/TPI) therapy for mCRC, examining its benefits across patient subgroups and evaluating safety relative to TFD/TPI monotherapy.

Materials And Methods: Following preferred reporting items for systematic reviews and meta-analysis statements, we conducted a thorough literature search from 15 October to 11 November 2023, covering MEDLINE, Embase and the Cochrane database.

Clomazone exposure-driven photosynthetic responses plasticity of Pontederia crassipes.

Clomazone is known to contaminate aquatic environments and have a negative impact on macrophytes. However, recent reports suggests that Pontederia crassipes Mart. can withstand clomazone exposure while maintaining growth rates.

Descriptive analysis of the cases published in the Align® Global Gallery.

Introduction: Social media enhanced access to information, making it easier to share dental treatments.

Objective: This study aimed to conduct a descriptive analysis of the clinical cases published on the Align® Global Gallery platform.

Material And Methods: A retrospective cross-sectional study of 1,582 cases was conducted, data extracted referred to the following basic information: case number; patient's age; reported gender; Invisalign® package modality; treatment time; aligner exchange protocol; total number of aligners per arch; type of retainers, and inclusion of initial and final panoramic and cephalometric radiographs.

Association Between Vedolizumab Treatment and Arthritis/Arthralgia in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

Background And Aims: Vedolizumab is a humanized gut selective drug that targets α4β7 integrin and has been used successfully in the treatment of inflammatory bowel disease (IBD). Pivotal studies have already demonstrated the drug's safety, but some real-life cohorts have shown an increase in arthralgia and arthritis in patients using vedolizumab. These findings raised the question of whether these joint symptoms are extraintestinal manifestations of IBD (since the drug acts only in the gut) or if they are associated with the use of vedolizumab.

Chagas Disease Diagnosis with -Exclusive Epitopes in GFP.

Serological tests are critical tools in the fight against infectious disease. They detect antibodies produced during an adaptive immune response against a pathogen with an immunological reagent, whose antibody binding characteristics define the specificity and sensitivity of the assay. While pathogen proteins have conveniently served as reagents, their performance is limited by the natural grouping of specific and non-specific antibody binding sites, epitopes.

Unconventional Edible Plants of the Amazon: Bioactive Compounds, Health Benefits, Challenges, and Future Trends.

The pursuit of an improved quality of life is a major trend in the food market. This is driving the reformulation of the industry's product portfolio, with the aim of providing nourishment while also contributing to beneficial health metabolic processes. In this context, the use of local biodiversity and the recovery of the traditional knowledge associated with the consumption of vegetables that grow spontaneously in nature emerge as more sustainable and nutritionally adequate concepts.