6,131 results match your criteria: "Febrile Seizures"
Febrile Seizures, Ongoing Epileptiform Activity, and the Resulting Long-Term Consequences: Lessons From Animal Models.
Pediatr Neurol
December 2024
Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, Canada. Electronic address:
Article Synopsis
Developmental and epileptic encephalopathy 56 due to YWHAG variants: 12 new cases and review of the literature.
Eur J Paediatr Neurol
November 2024
Movement Disorders Unit, Pediatric Neurology Department, Institut de Recerca, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain; European Reference Network for Rare Neurological Diseases (ERN-RND), Barcelona, Spain; U-703 Centre for Biomedical Research on Rare Diseases (CIBER-ER), Instituto de Salud Carlos III, Barcelona, Spain. Electronic address:
Article Synopsis
Development and validation of a nomogram for the estimation of the prognosis of patients presenting with a febrile seizure.
BMC Pediatr
October 2024
Department of Pediatrics, Qilu Hospital of Shandong University, No.107 West Wenhua Road, Jinan, Shandong Province, 250012, China.
Article Synopsis
- Febrile seizures are common in young children and can lead to epilepsy, affecting their health and development, so this study aimed to create a predictive tool to assess the risk of this transition.
- Researchers analyzed data from 306 pediatric patients to identify key clinical factors associated with the risk of developing epilepsy after febrile seizures, utilizing various statistical methods.
- The resulting predictive nomogram, based on five significant factors, showed strong accuracy in risk assessment, helping doctors make better treatment decisions for children experiencing febrile seizures.
Imipenem-Cilastatin-Induced Seizures: A Case Report.
Curr Drug Saf
October 2024
Department of Pharmacy, Main Military Training Hospital of Tunis, Tunis, Tunisia.
Article Synopsis
- Imipenem-cilastatin, a carbapenem antibiotic, can cause rare side effects such as seizures, as highlighted by a case involving a 20-year-old male who experienced seizures and respiratory distress after its administration.
- Despite initial anti-epileptic treatment, seizures recurred until the antibiotic was discontinued, leading to the patient's stabilization, which suggests a link between the medication and the seizures.
- This case emphasizes the need for healthcare providers to recognize and monitor the potential neurological effects of imipenem-cilastatin, especially in vulnerable patients, and to consider both the benefits and risks when choosing antibiotics.
Clinical characteristics and serum 25-hydroxyvitamin D levels in children with febrile seizures in China.
Sci Rep
October 2024
Department of Pediatrics, Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.
Article Synopsis
- The study looked at vitamin D levels in children with febrile seizures in Luzhou, China, comparing them to healthy kids.
- It found that kids with seizures had lower vitamin D levels and that older kids had even less vitamin D.
- The researchers suggested that getting more vitamin D through supplements and spending time outside could help prevent seizures in children.
Etiological Profile of First Episode Seizures in Paediatric Patients at a Tertiary Care Centre: A Descriptive Cross-sectional Study.
JNMA J Nepal Med Assoc
March 2024
Nepal Medical College Teaching Hospital, Jorpati, Kathmandu, Nepal.
Article Synopsis
- Seizures are the most common emergency for kids and this study looks at kids in Eastern Nepal who had their first seizure.
- The study included 170 children, mostly boys, and most of them were younger than 5 years old, with fever being the most common symptom when they had seizures.
- The main causes of these seizures were febrile seizures (from fever), neurocysticercosis (a type of infection), and meningitis, and doctors used different tests to figure out what's causing the seizures.
Simple febrile seizure et causa bronchopneumonia with complex congenital heart disease.
Glob Cardiol Sci Pract
August 2024
Department of Emergency Medicine, Hang Tuah University, Surabaya, Indonesia.
Article Synopsis
- Complex congenital heart disease (CHD) is not commonly linked to febrile seizures in children, but a case of a 2-year-old girl illustrates a potential connection with bronchopneumonia.
- The child was severely malnourished and presented with simple febrile seizures, alongside diagnostic findings of lung and heart abnormalities.
- Prompt treatment with diazepam and supportive care highlighted the need for an integrated approach to manage febrile seizures in patients with complex congenital heart issues, emphasizing the role of healthcare teams in preventing recurrence.
[Pre-hospital and hospital treatment of febrile seizures].
Rev Neurol
October 2024
Institut de Recerca Biomèdica Lleida, Lleida, España.
Article Synopsis
- Febrile seizures are common reasons why kids go to the hospital, and this study looks at how to better treat them since there are no clear guidelines, especially for complex febrile seizures.
- The study included 266 children who had febrile seizures at a hospital and found that most seizures were simple, with many patients receiving treatment before arriving at the hospital.
- The researchers discovered that many tests were done on these patients, even when the cause of the fever was found, suggesting that not every test is necessary for every child.
Temporopolar blurring signifies abnormalities of white matter in mesial temporal lobe epilepsy.
Ann Clin Transl Neurol
November 2024
Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Article Synopsis
- The study focused on patients with temporal lobe epilepsy and hippocampal sclerosis, comparing those with gray-white matter abnormalities (GMB+) to those without (GMB-).
- Researchers analyzed 105 patients and 61 healthy controls using MRI and light microscopy, examining brain structure and connectivity related to their epilepsy.
- Findings indicated that GMB+ patients showed more extensive white matter damage and a higher rate of certain types of hippocampal sclerosis, which may influence surgical treatment decisions.
SMS-Based Active Surveillance of Adverse Events following Immunization in Children: The VigiVax Study.
Vaccines (Basel)
September 2024
Section of Pharmacology, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
Article Synopsis
- The study looked at how well using text messages (SMS) can help track side effects from vaccines compared to older methods.
- Parents of young children were asked about any problems after their kids got vaccinated, and responses were collected and checked for accuracy.
- Results showed that most side effects were not serious, and the study suggested that using digital methods like SMS can help improve reporting about vaccine safety.
Ultrastructural Analysis of the Large Neuronal Perikarya in an Injured Dentate Nucleus Using an Experimental Model of Hyperthermia-Induced Convulsions: The First Qualitative and Quantitative Study.
J Clin Med
September 2024
Department of Medical Pathomorphology, Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English, Medical University of Bialystok, 15-269 Białystok, Poland.
Article Synopsis
- Febrile seizures are a common type of convulsion in kids, and this study aims to understand how they happen by looking closely at brain cells in rats.
- The researchers heated the rats to make them have seizures, then used special microscopes to see what happened to the brain cells.
- They found that the brain cells showed serious damage when the rats were heated, which could help scientists find ways to prevent seizures in children in the future.
Expanding the Spectrum of Autosomal Dominant -Related Disease: Case Report and Literature Review.
Genes (Basel)
September 2024
Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Article Synopsis
- Developmental and epileptic encephalopathies (DEE) are disorders that can be caused by new mutations in a specific gene, leading to different symptoms, from severe conditions to milder ones like autism.
- A case study of a six-year-old boy showed he had a new mutation in that gene, but he did not develop epilepsy and had a normal brain scan over five years.
- This case helps us understand that not everyone with mutations in this gene will have serious problems, which is important for doctors to know when diagnosing developmental delays.
Case report: Epilepsy during the use of recombinant human growth hormone: a report on two cases and a literature review.
Front Pharmacol
September 2024
Department of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Article Synopsis
- The text talks about two boys in China who had epilepsy while taking a treatment called recombinant human growth hormone (rhGH).
- The first boy had a history of convulsions but his epilepsy was controlled after stopping rhGH and starting medication.
- The second boy showed signs of epilepsy after starting treatment but didn’t feel better when one of his other medications was stopped.
Influenza Infection During Pregnancy and Risk of Seizures in Offspring.
JAMA Netw Open
September 2024
Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Article Synopsis
- - The study investigates the connection between maternal influenza infection during pregnancy and the likelihood of children experiencing seizures by analyzing a large dataset of mother-offspring pairs in Taiwan from 2004 to 2013.
- - Mothers with influenza were compared to a control group without the infection, matched on factors like age and delivery date, with follow-up data collected until 2020 to assess childhood seizure incidence.
- - Results indicated findings through adjusted hazard ratios suggest a potential association between maternal influenza during pregnancy and an increased risk of seizures in children, including epilepsy and febrile seizures.
Risk factors for secondary epilepsy following febrile seizures in children: A meta-analysis.
Epilepsy Behav
December 2024
Department of Pediatrics, First Affifiliated Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang 050000, China. Electronic address:
Article Synopsis
- The objective of the study was to find out what factors can increase the risk of children developing epilepsy after having febrile seizures.
- Researchers looked at many studies and analyzed data from 23 different research articles involving over 5,000 children.
- The results showed that several factors like having multiple seizures, a family history of epilepsy, and other medical issues can increase the risk, while being female didn’t really matter.
Transition from rectal to intranasal route among mostly pediatric patients with repeated prescriptions of rescue benzodiazepines for seizure emergencies.
Epilepsy Behav
December 2024
Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, The Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Article Synopsis
- The study looked at how the use and cost of certain medications (non-IV rescue benzodiazepines) changed after new options (intranasal midazolam and diazepam) became available from 2016 to 2022.
- Out of 4,444 patients, over half switched from using rectal diazepam to the new intranasal options, and this trend increased each year.
- The study found that the costs for the last medication patients used were higher than for the first one, meaning those who switched to intranasal medications ended up paying more.
Efficacy of a mitochondrial drug cocktail in preventing acute encephalopathy with biphasic seizures and late reduced diffusion.
J Neurol Sci
November 2024
Department of Pediatrics, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo, Japan.
Article Synopsis
- Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) can be hard to tell apart from long-lasting febrile seizures, especially in kids.
- A study looked at the effects of a special mix of vitamins and supplements, called a "mitochondrial cocktail," to see if it can help prevent AESD in children with prolonged seizures related to fever.
- The results showed that kids who received the mitochondrial cocktail had a much lower chance of developing AESD compared to those who didn't, suggesting that giving this mix early could be helpful in preventing the condition.
Prognostic factors and treatment outcomes in pediatric autoimmune encephalitis: a multicenter study.
Front Neurol
September 2024
Department of Pediatric Neurology, King Fahad Medical City, Riyadh, Saudi Arabia.
Article Synopsis
- Autoimmune encephalitis (AE) is a serious brain condition that can suddenly cause problems like confusion, seizures, and unusual behavior, and is often triggered by infections in kids.
- Doctors have learned a lot about how to identify and treat AE, including using new tests to find specific antibodies that help diagnose it and new medications to fight it.
- Early treatment is important and helps many people, but about 40% of patients don't respond to the first treatment, leading researchers to develop new treatment options.
() is a catalase-negative, gram-positive cocci, rarely reported as a cause of human infections. We report a case of probable food poisoning caused by in an adult female. A 58-year-old female was brought to the Emergency Department with a history of sudden onset of high-grade fever, vomiting, and febrile seizures.
View Article and Find Full Text PDFElevated cerebrospinal fluid neuronal injury biomarkers within 24 hours of onset in infection-triggered acute encephalopathy compared to complex febrile seizures.
J Neurol Sci
November 2024
Department of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
Article Synopsis
- - The study aimed to compare neuronal injury biomarkers in cerebrospinal fluid of pediatric patients experiencing complex febrile seizures (CFS) versus those with infection-triggered acute encephalopathy (AE), specifically looking at the pathogenesis of AE with biphasic seizures.
- - Researchers analyzed cerebrospinal fluid samples from 63 patients collected within 24 hours of neurological symptoms; results indicated significantly higher levels of the biomarkers S100B and GDF-15 in patients diagnosed with AESD and AE, respectively.
- - The findings suggest that elevated S100B levels indicate active astrocyte involvement in AESD pathology, while increased GDF-15 points to a stronger defense response linked to more severe neurological injuries in infection-trigger
Predictive Value of Neutrophil-Lymphocyte Ratio and Other Inflammation Indices in Febrile Seizures in Children.
J Clin Med
September 2024
Ümraniye Training and Research Hospital, Department of Pediatrics, Pediatric Allergy and Immunology Clinic, University of Health Sciences, 34764 İstanbul, Türkiye.
Article Synopsis
- - Increasing evidence suggests inflammation plays a role in febrile seizures (FS), prompting a study on various accessible inflammatory markers like the neutrophil-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII).
- - The study included 300 children (100 with FS, 100 febrile controls, and 100 healthy controls) and found significantly higher neutrophil counts and lower lymphocyte counts in the FS group compared to others, along with elevated inflammatory indexes (NLR, SII, SIRI, NLPR, PIV).
- - The identified optimal cut-off values for predicting FS raise the potential of using these affordable blood markers in diagnosing febrile seizures, making the approach
The broad spectrum of clinical manifestations observed in three patients with L2 hydroxyglutaric aciduria spans from febrile seizures to complex dystonia.
Mol Genet Metab Rep
December 2024
Movement Disorders Division, Department of Neurology, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.
Article Synopsis
- L-2 hydroxyglutaric aciduria (L-2-HGA) is a rare genetic disorder that leads to various neurological symptoms and requires careful diagnosis for effective treatment.
- In a case series of three patients, symptoms included febrile seizures, hyperactivity, and intellectual challenges, with one case showing cervical dystonia.
- Brain MRIs of two patients revealed distinctive patterns associated with L-2-HGA, emphasizing the need for increased awareness and early diagnosis to enable the use of management strategies like riboflavin, levocarnitine, and dietary changes.
Myelin oligodendrocyte glycoprotein antibody-associated cerebral cortical encephalitis with super-refractory status epilepticus.
Brain Dev
November 2024
Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
Article Synopsis
- * A case of a 9-year-old boy revealed that his seizures persisted despite treatment with thiopental, leading to super-refractory status epilepticus; however, seizure control was achieved using continuous ketamine infusion and intrathecal dexamethasone therapy.
- * The patient's diagnosis of MOG-CCE was confirmed with positive ani-MOG antibodies, and after receiving multiple treatments, he remained seizure-free for six months without relapse.*
Quality of life in -related seizure disorders across the lifespan.
Brain Commun
August 2024
Department of Genetics, UMC Utrecht Brain Center, University Medical Center Utrecht, 3583CX Utrecht, The Netherlands.
Article Synopsis
- - This study focuses on understanding how disease characteristics and quality of life evolve across different life stages for individuals with Dravet syndrome and related seizure disorders, aiming to help doctors provide better personalized care.
- - Researchers gathered data through questionnaires, medical records, and interviews, tracking changes in health-related quality of life over a seven-year period, with particular attention to how different factors impact patient well-being.
- - Findings show that Dravet syndrome patients reported lower quality of life compared to those with non-Dravet conditions, although older Dravet patients exhibited improved quality of life, which was linked to fewer behavioral issues and better physical independence.
Clinical and sociodemographic predictors of depressive symptoms in epilepsy patients in a single tertiary epilepsy center.
Acta Neurol Belg
September 2024
Clinic of Neurology, University Clinical Center Vojvodina, 1 Hajduk Veljkova St, Novi Sad, 21 000, Serbia.
Purpose: The purpose of this cross-sectional study was to determine the frequency of depressive symptoms in patients with epilepsy (PWE) in a tertiary epilepsy center and to analyse possible predictors of depression in several domains, including clinical characteristics of epilepsy and sociodemographic factors.
Methods: PWE patients who visited our epilepsy clinic during the 6th month in 2020 and 2021 were enrolled in our study. To collect the data, structured scales were created for the clinical characteristics of the disease and for the sociodemographic data.