6,131 results match your criteria: "Febrile Seizures"
Eur J Med Genet
December 2024
Rare Diseases and Medical Genetics Unit, Bambino Gesù Children's Hospital, IRCSS, Rome, Italy.
O'Donnell-Luria-Rodan (ODLURO) syndrome is an autosomal dominant neurodevelopmental disorder mainly characterized by global development delay/intellectual disability, white matter abnormalities, and behavioral manifestations. It is caused by pathogenic variants in the KMT2E gene. Here we report seven new patients with loss-of-function KMT2E variants, six harboring frameshift/nonsense changes, and one with a 7q22.
View Article and Find Full Text PDFVaccine
December 2024
Optum Epidemiology, Boston, MA, USA.
Background: Limited data exists regarding the safety of the COVID-19 2023-2024 vaccine formulations and whether the safety profiles differ from the original formulations. We evaluated the association between the BNT162b2 XBB COVID-19 vaccine and the risk of 20 pre-specified adverse events of special interest (AESIs).
Methods: We identified commercially-insured individuals in the US age ≥ 6 months who received the BNT162b2 XBB COVID-19 vaccine between September 11, 2023 and January 15, 2024 within the Optum pre-adjudicated database.
Int Immunopharmacol
December 2024
Department of Pediatrics, the First Medical Centre, Chinese PLA General Hospital, Beijing, China; Senior Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China; Medical School of Chinese People's Liberation Army, Beijing, China. Electronic address:
Febrile Infection-Related Epilepsy Syndrome (FIRES) is an infrequent yet severe form of epilepsy that rapidly evolves into status epilepticus following a febrile episode. Prompt diagnosis coupled with effective treatment strategies is critical for improving patient outcomes. Herein, we describe the case of an 11-year-old male with FIRES who was successfully treated with tocilizumab, resulting in no further seizures or residual disability.
View Article and Find Full Text PDFBMC Infect Dis
December 2024
Children's Hospital of Fudan University (Xiamen Branch), Xiamen Children's Hospital, No. 92-98, Yibin Road, Huli District, Xiamen, 361006, China.
J Family Med Prim Care
October 2024
Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.
Acta Neuropathol
November 2024
Comprehensive Epilepsy Center, NYU Grossman School of Medicine, New York, NY, USA.
Sudden unexplained death in childhood (SUDC) is death of a child ≥ 12 months old that is unexplained after autopsy and detailed analyses. Among SUDC cases, ~ 30% have febrile seizure (FS) history, versus 2-5% in the general population. SUDC cases share features with sudden unexpected death in epilepsy (SUDEP) and sudden infant death syndrome (SIDS), in which brainstem autonomic dysfunction is implicated.
View Article and Find Full Text PDFOrphanet J Rare Dis
November 2024
Department of Endocrinology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Genetics, Metabolism, Beijing, 100045, China.
Genes (Basel)
October 2024
Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
Background: Febrile seizures (FSs) are the most common form of epilepsy in children aged between six months and five years. The exact cause is unknown, but several studies have demonstrated the importance of genetic predisposition, with increasing involvement of receptors and ion channels. The present study aims to identify novel pathogenic variants in Italian patients with FSs.
View Article and Find Full Text PDFCells
November 2024
Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, 44, Toreza Prospekt, Saint Petersburg 194223, Russia.
Febrile seizures (FSs) are defined as seizures occurring in children aged 6 months to 5 years with a background of elevated body temperature. It is one of the most common neurological disorders of childhood, emphasizing the importance of understanding the causes of FSs and their impact on the developing nervous system. However, there are significant limitations to the technologies currently available for studying the etiology and pathophysiology of seizures in humans.
View Article and Find Full Text PDFFront Genet
November 2024
Department of Basic Medical Sciences, College of Medicine, Taibah University Medina, Medina, Saudi Arabia.
Tunis Med
November 2024
Pediatrics and Neonatology department, Yasminette Ben Arous. University El Manar, Faculty of Medecine of Tunis, Tunisia.
Neurohospitalist
September 2024
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
Background: Scrub typhus is an acute febrile infectious disease highly prevalent in the Asia Pacific region, often referred to as the "tsutsugamushi triangle." This mite-borne rickettsial zoonosis is caused by , an intracellular Gram-negative organism that primarily targets endothelial cells. The resulting vasculitis leads to multisystem involvement.
View Article and Find Full Text PDFCureus
October 2024
Department of Pediatrics, Haibara General Hospital, Shizuoka, JPN.
BMC Pediatr
November 2024
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Pediatr
January 2025
Epilepsy Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada.
Pediatr Neonatol
October 2024
Department of Pediatrics, Chonnam National University Medical School, Gwangju, South Korea; Department of Pediatrics, Chonnam University Children's Hospital, Gwangju, South Korea. Electronic address:
Front Pediatr
October 2024
Pediatric Emergency Department, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, China.
Radiol Case Rep
January 2025
Department of Paediatrics and Child Health, Aga Khan Hospital Tanzania, Dar Es Salaam 2289, Tanzania.
Iran J Child Neurol
September 2024
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.
EBioMedicine
November 2024
Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. Electronic address:
Front Pediatr
October 2024
Structural/Congenital Heart Disease and Ultrasound Center, Children's Hospital, China Medical University, Taichung, Taiwan.
Clin Pediatr (Phila)
October 2024
Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt.
Int J Mol Sci
October 2024
Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, 194223 Saint Petersburg, Russia.
The study of the pathogenesis of febrile seizures and their consequences frequently necessitates gene expression analysis. The primary methodology employed for such analysis is reverse transcription with quantitative polymerase chain reaction (RT-qPCR). To ensure the accuracy of data obtained by RT-qPCR, it is crucial to utilize stably expressed reference genes.
View Article and Find Full Text PDFAnn Neurol
October 2024
Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.