Nickel-palladium bimetallic nanoparticles supported on multi-walled carbon nanotubes; versatile catalyst for Sonogashira cross-coupling reactions.

We have developed an efficient method to generate highly active nickel-palladium bimetallic nanoparticles supported on multi-walled carbon nanotubes (Ni-Pd/MWCNTs) by dry mixing of the nickel and palladium salts utilizing the mechanical energy of a ball-mill. These nanoparticles were successfully employed in Sonogashira cross-coupling reactions with a wide array of functionalized aryl halides and terminal alkynes under ligand and copper free conditions using a Monowave 50 heating reactor. Notably, the concentration of palladium can be lowered to a minimum amount of 0.