Assessing Preferences of Patients with Chronic Spontaneous Urticaria for Injectable Treatment Profiles.

Background: In the context of injectable biologic products approved or in development for chronic spontaneous urticaria (CSU), it is important to capture which treatment attributes matter most to patient and what trade-offs patients are willing to make.

Objectives: The CHOICE-CSU study aimed to quantify patient preferences toward injectable treatment attributes among patients with CSU, inadequately controlled by H1-antihistamines.

Methods: This was a two-phase cross-sectional patient preference study in adult patients with a diagnosis of CSU, inadequately controlled by H1-antihistamines.

Ultra-high-frequency Ultrasound in the Objective Assessment of Chlormethine Gel Efficacy: A Case Report.

Mycosis fungoides (MF) represent the most frequent form of cutaneous T-cell lymphoma (CTCL). Chlormethine gel has been approved as first-line therapy in MF. The classification of early forms of MF is clinically and histologically complex even for experienced clinicians.

Assessing Cancer Knowledge in the General Population of Bisha Province, Saudi Arabia: A Cross-Sectional Study.

Background Cancer is a major cause of morbidity and mortality worldwide. It is anticipated that the number of new cases in Saudi Arabia will increase yearly as a result of significant changes in lifestyle and population development. There is little to no information or studies concerning cancer awareness or knowledge among the residents of Bisha Province.

Extensible lateral approach versus sinus tarsi approach for sanders type II and III calcaneal fractures osteosynthesis: a randomized controlled trial of 186 fractures.

Aims: Which is the best extensile lateral (ELA) or sinus tarsi (STA) approach for osteosynthesis displaced intraarticular calcaneal fracture (DIACF) is still debatable. The current RCT's primary objective was to compare the complications incidence after open reduction and internal fixation of DIACFs through STA vs. ELA.

Family planning, pregnancy, and parenthood during surgical training: Experiences and perspectives from trainees and early career surgeons in Australia and New Zealand.

Objective: To identify and address areas for improvement within the current surgical training model in Australia and New Zealand relating to family planning and inflexible training as top barriers to gender equity in surgery.

Methods: A cross-sectional study of accredited surgical trainees and early career surgeons in Australia and New Zealand was conducted between September and October 2023. Participants were recruited by the RACS Fax Mentis, the Urological Society of Australia and New Zealand (USANZ) e-newsletter, and medical social media networks.

Arrangement and Development of Spicules in the Coral-killing Sponge, .

Rützler & Muzik, 1993 is a poriferan species that competes with corals and is known as a coral-killing sponge. However, limited information is available on its biology, including morphological traits. This study aims to examine the arrangement and development of spicules in various body parts of the sponge, including settled larvae.

The Family Anesthesia Experience (FAX): Implementing a Social Support-Focused Wellness Programme Across Multiple Residency Programmes.

Introduction: Lack of social support negatively impacts medical trainees' wellness. Programmes to educate medical trainees and their support persons (SPs) have been developed to improve resident wellness, but implementation of these programmes at other institutions remains unclear. We aimed to demonstrate the feasibility of implementing the Family Anesthesia Experience (FAX) programme across multiple institutions and to assess the programme's utility.

The Influence of a Deep Learning Tool on the Performance of Oral and Maxillofacial Radiologists in the Detection of Apical Radiolucencies.

Title: The Influence of a Deep Learning Tool on the Performance of Oral and Maxillofacial Radiologists in the Detection of Apical Radiolucencies.

Objectives: This study aimed to assess the impact of a deep learning model on oral radiologists' ability to detect periapical radiolucencies on periapical radiographs. The secondary objective was to conduct a regression analysis to evaluate the effects of years of experience, time to diagnose, and specialty.

Hospitals Infrequently Receive EMS Patient Care Reports in the Era of Electronic Medical Records: A Preliminary Report.

Objectives: Emergency Medical Services (EMS) patient care reports (PCRs) are an important component for the transfer of patient care from EMS systems to hospitals and a foundational element of EMS quality improvement (QI). The PCR may serve as the only objective source of information for EMS patient presentation. Surprisingly little data, either objective or anecdotal, exists regarding the reliability of this process.

Residual silicone oil does appear after conventional removal and contributes to postoperative emulsification.

Purpose: To validate the presence of residual non-emulsified silicone oil (SO) following conventional surgical removal techniques used in vitreoretinal surgery and provide insights for optimizing surgical parameters and reducing subsequent emulsification-related complications.

Methods: The two surgical steps of repeated fluid-air exchange (FAX), including aspiration and infusion, were simulated in vitro to investigate their effectiveness in removing residual non-emulsified SO under various clinical settings. Aspiration was performed at three different positions with respect to the SO interface (i.

Intrinsic Capacity Impairments (ICOPE Step 1 and Step 2), Cardiometabolic Risk and Immune Resilience: An Exploratory Analysis from the Gan-Dau Healthy Longevity Plan.

Importance: Intrinsic capacity (IC), defined by the World Health Organization's Integrated Care for Older People (ICOPE) framework, is crucial for promoting healthy aging. Understanding the associations between IC impairments and age-related biomarkers can provide insights into the underlying pathophysiological mechanisms and potential interventions.

Objective: To investigate the associations between IC impairments (ICOPE step 1 and step 2, respectively) and aging-related biomarkers, including inflammatory and cardiometabolic markers, in community-dwelling middle-aged and older adults.

Intrinsic Capacity and Its Association with Adverse Health Outcomes in Older Japanese Outpatients.

Objectives: This study aimed to provide evidence regarding the clinical significance of assessing intrinsic capacity (IC).

Design: Longitudinal study.

Setting: Frailty clinic.

Does a Poor Preoperative Nutritional Status Impact outcomes of Heart Valve Surgery?

Background: Malnutrition has been variously associated with poor postoperative outcomes. Of note, 10-25 % of cardiac surgery patients are reported to be malnourished.

Objectives: To assess the impact of nutritional status (evaluated with the Geriatric Nutritional Risk Index - GNRI) on outcomes of older patients undergoing heart valve surgery.

The Interplay among Respiratory Failure, Delirium, Frailty and Severity of Illness in Hospitalized Older Medical Patients: A Nationwide Multicenter Observational Study.

Background: Prevalence, correlates and outcomes of respiratory failure (RF) were never studied in large populations of older patients hospitalized in acute care medical settings. Little is known about the possible association between RF and delirium, and whether these two syndromes, alone or in combination, may affect short-term mortality.

Objectives: To investigate prevalence and features of RF, the association between delirium and RF, and their effect on short-term mortality.

Evaluation of Handgrip Strength Asymmetry to Assess Sarcopenia in Older Patients with Chronic Low Back Pain: A Retrospective Cross-Sectional Study.

Background: Handgrip strength (HGS) is a crucial measurement for diagnosing sarcopenia, and HGS asymmetry indicates functional impairment and correlates with adverse health outcomes. Although chronic low back pain (CLBP) often coexists with sarcopenia in older people, the association between HGS asymmetry and sarcopenia in that population has not been investigated.

Objectives: This study examines the association between HGS asymmetry and sarcopenia in older patients with CLBP and explores differences in the proportion of sarcopenia and severe sarcopenia according to the severity of HGS asymmetry.

Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85-89 Years in Kawasaki, Japan: A Cross-sectional Study.

Background: While physical activity (PA) can reduce physical frailty, the specific intensity and duration of PA required to prevent frailty are yet to be defined.

Objectives: This study aimed to investigate the relationship between objectively measured PA or sedentary behavior (SB) and physical frailty and to explore the theoretical effect of replacing SB with different intensities of PA on the risk of frailty.

Design: Cross-sectional study.

Comparative Analysis of Gait Speed Measurement Protocols: Static Start Versus Dynamic Start in a Cross-Sectional Study Using Light Detection and Ranging.

Background: There is currently no standardized protocol for the measurement of gait speed in older adults, particularly regarding the choice between static versus dynamic start.

Objectives: This study aimed to assess the impact of removing the initial phase on gait speed measurement and compare the correlation of different measurement methods with other physical performance metrics.

Design: A cross-sectional study.

Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis.

Despite evidence linking the gut microbiome to neuropathic pain (NP), it is not known if altering gut microbiota can alleviate NP via the microbiome-gut-brain axis. This study examined if healthy gut microbiota of sham male rats (Sham+V) and dysbiotic gut microbiota of NP rats (spinal nerve ligation: NP, SNL+V) can be disrupted and restored, respectively, via fecal microbiota transplant (FMT) from the opposite group [Sham+(SNL-FMT) and SNL+(Sham-FMT), respectively]. All groups received FMT daily for two weeks, followed by three weeks without FMT.

Modulatory Effect of Blood LDL Cholesterol on the Association between Cerebral Aβ and Tau Deposition in Older Adults.

Background: This study investigates the synergistic relationship between blood low-density lipoprotein cholesterol (LDL-C) and cerebral beta-amyloid (Aβ) in relation to tau deposition, a key factor in the pathology of Alzheimer's disease (AD), in older adults across a diverse cognitive spectrum.

Objectives: To examine whether higher levels of LDL-C in the blood moderate the association of cerebral Aβ with tau deposition in older adults, including those with normal cognition, mild cognitive impairment, and Alzheimer's disease dementia.

Design: Cross-sectional design.