MedSegBench: A comprehensive benchmark for medical image segmentation in diverse data modalities.

MedSegBench is a comprehensive benchmark designed to evaluate deep learning models for medical image segmentation across a wide range of modalities. It covers a wide range of modalities, including 35 datasets with over 60,000 images from ultrasound, MRI, and X-ray. The benchmark addresses challenges in medical imaging by providing standardized datasets with train/validation/test splits, considering variability in image quality and dataset imbalances.

Virtual birefringence imaging and histological staining of amyloid deposits in label-free tissue using autofluorescence microscopy and deep learning.

Systemic amyloidosis involves the deposition of misfolded proteins in organs/tissues, leading to progressive organ dysfunction and failure. Congo red is the gold-standard chemical stain for visualizing amyloid deposits in tissue, showing birefringence under polarization microscopy. However, Congo red staining is tedious and costly to perform, and prone to false diagnoses due to variations in amyloid amount, staining quality and manual examination of tissue under a polarization microscope.

Evaluation of SLC6A2 and CYP2D6 polymorphisms' effects on atomoxetine treatment in attention deficit and hyperactivity disorder.

Background: There is insufficient replicated data to establish a relationship between the polymorphisms of SLC6A2 and CYP2D6 and the treatment responses of atomoxetine (ATX) in ADHD. We focused on evaluating the effect of top-line single nucleotide polymorphisms (SNPs) in SLC6A2 and CYP2D6 on the ATX treatment response in attention deficit and hyperactivity disorder (ADHD).

Methods: Of 160 patient records, 34 patients who met the inclusion criteria were evaluated to determine the relationship between genotypes of ten SNPs (six of SLC6A2 and four of CYP2D6) and ATX treatment response.

Development of Graphene Oxide-Based Anticancer Drug Combination Functionalized with Folic Acid as Nanocarrier for Targeted Delivery of Methotrexate.

Graphene has become a prominent material in cancer research in recent years. Graphene and its derivatives also attract attention as carriers in drug delivery systems. In this study, we designed a graphene oxide (GO)-based methotrexate (MTX)-loaded and folic acid (FA)-linked drug delivery system.

Enhancing resolution and contrast in fibre bundle-based fluorescence microscopy using generative adversarial network.

Fibre bundle (FB)-based endoscopes are indispensable in biology and medical science due to their minimally invasive nature. However, resolution and contrast for fluorescence imaging are limited due to characteristic features of the FBs, such as low numerical aperture (NA) and individual fibre core sizes. In this study, we improved the resolution and contrast of sample fluorescence images acquired using in-house fabricated high-NA FBs by utilising generative adversarial networks (GANs).

Functional neural networks stratify Parkinson's disease patients across the spectrum of cognitive impairment.

Introduction: Cognitive impairment (CI) is a significant non-motor symptoms in Parkinson's disease (PD) that often precedes the emergence of motor symptoms by several years. Patients with PD hypothetically progress from stages without CI (PD-normal cognition [NC]) to stages with Mild CI (PD-MCI) and PD dementia (PDD). CI symptoms in PD are linked to different brain regions and neural pathways, in addition to being the result of dysfunctional subcortical regions.

Effectiveness of an online dialectical behavior therapy skills training in adults with attention-deficit/hyperactivity disorder: A randomized controlled trial.

Objective: The current study aims to examine the efficacy of an add-on dialectical behavior therapy skills training (DBT-ST) on adult attention-deficit/hyperactivity disorder (ADHD). The DBT-ST was applied online under the pandemic conditions that occurred after the study had started.

Methods: The current randomized controlled trial consists of an intervention group to whom the DBT-ST was applied in online setting and a waitlist control group who received treatment as usual (TAU).

[Investigation of the Relationship Between Akkermansia Genomic Diversity in Gut Microbiota and Parkinson's Disease Dementia].

Although it is known that the relative abundance of Akkermansia, a bacterial genus commonly associated with health, increases in the gut microbiota of Parkinson's disease (PD) patients, the exact reason for this increase remains unclear. This study was aimed to identify potential changes in Akkermansia within the gut microbiota of PD patients in Türkiye. For this purpose, shotgun metagenomics and a novel Akkermansia genus-specific amplicon sequencing technique was used to investigate the presence of specific Akkermansia strains associated with cognitive impairment (CI) stages in PD and to examine potential genes within these strains.

The Novel Hybrid Lattice Structure Approach Fabricated by Laser Powder Bed Fusion and Mechanical Properties Comparison.

Aluminum-based cellular structures are gaining a huge traction in several applications, including lightweight aircraft, military equipment, and heat exchangers. With additive manufacturing, the fabrication of complex periodic cellular structures with any unit cell form, size, and volume fraction has become a lot easier, allowing for more investment, research, and attention from both academia and industry. The aim of the research was to assess the manufacturability and performance of AlSi10Mg periodic cellular structures generated using the laser powder bed fusion process.

Metaproteogenomic analysis of saliva samples from Parkinson's disease patients with cognitive impairment.

Cognitive impairment (CI) is very common in patients with Parkinson's Disease (PD) and progressively develops on a spectrum from mild cognitive impairment (PD-MCI) to full dementia (PDD). Identification of PD patients at risk of developing cognitive decline, therefore, is unmet need in the clinic to manage the disease. Previous studies reported that oral microbiota of PD patients was altered even at early stages and poor oral hygiene is associated with dementia.

Lavandula stoechas extract incorporated polylactic acid nanofibrous mats as an antibacterial and cytocompatible wound dressing.

In recent years, great efforts have been devoted to the design and production of bioactive wound dressings that promote skin regeneration and prevent infection. Many plant extracts and essential oils have been widely accepted in traditional medicine for a wide variety of medicinal purposes, especially wound healing. Over the past decade, many studies have focused on manufacturing and designing wound dressings containing plant compounds and extracts.

Short-term climate change influence on surface water quality impacts from agricultural activities.

Climate change is a global phenomenon that directly affects agriculture by altering crop yield, nutritional quality, pests, and plant diseases. The North Aegean Basin located in Turkey has considerable agricultural importance due to its fertile soils. Agricultural activities have increased significantly and uncontrollably in the last decade, resulting in dramatic changes in nitrate and phosphorus levels in surface water within the watershed.

Methylprednisolone 100 mg tablet formulation with pea protein: experimental approaches over intestinal permeability and cytotoxicity.

Objective: This study was carried out to transform the hydrolyzed pea protein into a pharmaceutical tablet form by masking methylprednisolone.

Significance: This study provides some crucial contributions in showing how functional excipients such as pea protein, which are generally used in food industries, can be used in pharmaceutical product formulations and their effects.

Methods: Methylprednisolone was formulated using spray drying technology.

Efficiency Research of Conformal Channel Geometries Produced by Additive Manufacturing in Plastic Injection Mold Cores (Inserts) Used in Automotive Industry.

In the production of geometries that traditional methods cannot produce, it is seen that additive manufacturing (AM) technology, which has come to the fore, has been used extensively in conformal cooling channel (CCC) applications in recent years. This study, conducted within the scope of CCC's use of applied mold cores in automotive industry plastic part production, aimed to reduce the cycle time in the injection printing process. The v1 geometry, which gives the analysis results for ideal printing quality from the channel geometries developed with three different design approaches, is produced with direct metal laser sintering, which is an AM laser sintering technology, and the injection printing cycle time has been reduced by 38%.

Cubic-shaped corylus colurna extract coated CuO nanoparticles-based smartphone biosensor for the detection of ascorbic acid in real food samples.

Ascorbic acid (AA) is a highly water-soluble organic chemical compound and plays a significant role in human metabolism. For the purpose of food quality monitoring, this study focuses on the development of a smartphone-integrated colorimetric and non-enzymatic electrochemical Corylus Colurna (CC) extract-CuO nanoparticles (CuO NPs) biosensor to detect AA in real food samples. The characterization of the CC-CuO NPs was determined using SEM, SEM/EDX, HRTEM, XRD, FTIR, XPS, TGA, and DSC.

Parallel molecular alteration between Alzheimer's disease and major depressive disorder in the human brain dorsolateral prefrontal cortex: an insight from gene expression and methylation profile analyses.

Alzheimer's disease (AD) and major depressive disorder (MDD) are comorbid neuropsychiatric disorders that are among the leading causes of long-term disability worldwide. Recent research has indicated the existence of parallel molecular mechanisms between AD and MDD in the dorsolateral prefrontal cortex (DLPFC). However, the premorbid history and molecular mechanisms have not yet been well characterized.

Release kinetics modelling and in vivo-vitro, shelf-life study of resveratrol added composite transdermal scaffolds.

In this article, the suitability of composite transdermal biomaterial for wound dressing applications is discussed. Bioactive, antioxidant Fucoidan and Chitosan biomaterials were doped into polyvinyl alcohol/β-tricalcium phosphate based polymeric hydrogels loaded with Resveratrol, which has theranostic properties, and biomembrane design with suitable cell regeneration properties was aimed. In accordance with this purpose, tissue profile analysis (TPA) was performed for the bioadhesion properties of composite polymeric biomembranes.

Nano-material utilization in stem cells for regenerative medicine.

The utilization of nanotechnology in regenerative medicine has been globally proven to be the main solution to many issues faced with tissue engineering today, and the theoretical and empirical investigations of the association of nanomaterials with stem cells have made significant progress as well. For their ability to self-renew and differentiate into a variety of cell types, stem cells have become popular candidates for cell treatment in recent years, particularly in cartilage and Ocular regeneration. However, there are still several challenges to overcome before it may be used in a wide range of therapeutic contexts.

An LED-Based structured illumination microscope using a digital micromirror device and GPU accelerated image reconstruction.

When combined with computational approaches, fluorescence imaging becomes one of the most powerful tools in biomedical research. It is possible to achieve resolution figures beyond the diffraction limit, and improve the performance and flexibility of high-resolution imaging systems with techniques such as structured illumination microscopy (SIM) reconstruction. In this study, the hardware and software implementation of an LED-based super-resolution imaging system using SIM employing GPU accelerated parallel image reconstruction is presented.

The Mediator Role of Organizational Justice in the Relationship Between School Principals' Agile Leadership Characteristics and Teachers' Job Satisfaction.

Teachers with high job satisfaction become more effective and productive by showing high performance and positively affecting student and school outcomes. This study investigates the relationship between school principals' agile leadership characteristics, organizational justice, and job satisfaction, and sheds light on the role of organizational justice in the relationship between agile leadership and job satisfaction. To achieve this aim, a theoretical model has been put forward and this model has been tested with the data collected from 409 teachers working in public schools in Istanbul.

Relationship Satisfaction and Well-being During the COVID-19 Pandemic: Examining the Associations with Interpersonal Emotion Regulation Strategies.

Background: The COVID-19 pandemic has changed our interpersonal relationships drastically. However, few research studies have examined pandemic-induced stress and its impact on relationship quality. The current research aimed to examine COVID-19 related stress and anxiety in relation to relationship satisfaction, well-being (i.

Future Directions on BIPOC Youth Mental Health: The Importance of Cultural Rituals in the COVID-19 Pandemic.

Culture plays an important role in the development of mental health, especially during childhood and adolescence. However, less is known about how participation in cultural rituals is related to the wellbeing of youth who are Black, Indigenous, and People of Color (BIPOC), and part of the Global Majority. This is crucial amid the COVID-19 pandemic, a global event that has disproportionally affected BIPOC youth and disrupted participation in rituals.

An adaptive feature extraction method for classification of Covid-19 X-ray images.

This study aims to detect Covid-19 disease in the fastest and most accurate way from X-ray images by developing a new feature extraction method and deep learning model . Partitioned Tridiagonal Enhanced Multivariance Products Representation (PTMEMPR) method is proposed as a new feature extraction method by using matrix partition in TMEMPR method which is known as matrix decomposition method in the literature. The proposed method which provides 99.

Relationship dynamics: the protective effect of relationship satisfaction and dependency on parents' mental health after having a preterm baby.

Background: Having a premature infant who is hospitalized with the risk of death and potential health problems is a traumatic experience for many parents. The present study investigated the depression, anxiety, stress, and post-traumatic growth (PTG) experienced by couples after the premature birth of their babies in terms of their relationship dynamics.

Participants And Procedure: The study was conducted on 209 individuals - 159 mothers (76.

Determination of peaking factors for sewerage system in Antalya, tourism capital of Turkey.

The design of wastewater system pipe size is traditionally based on the maximum wastewater flow that is a function of multiple factors. Understanding the appropriate peaking factors (PF) by using daily flow variations through wastewater collection systems (WWCS) is essential for cost-effective design. This paper describes the maximum and minimum PFs by using wastewater flow data of four separate residential areas such as Lara, Belek-1, Kemer, and Hurma in Antalya, which is the tourism capital of Turkey.