1,293 results match your criteria: "Fasa University of Medical Sciences[Affiliation]"

Article Synopsis
  • The study explores the challenges of assessing osteoporosis in Iran, focusing on the high costs and limited availability of traditional diagnostic tools.
  • Various machine learning methods were used to evaluate osteoporosis risk factors, finding that the extreme gradient boosting (XGB) model offered the highest accuracy (0.79) and AUC (0.78) compared to other methods like random forest and decision trees.
  • Implementing ML algorithms like XGB for early osteoporosis identification could reduce health complications and financial burdens on healthcare systems, addressing a critical public health issue.
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The first step to reducing the growing burden of cardiovascular disease (CVD) is to find modifiable risk factors with the highest burden in each population. Urban and rural citizens may have different priorities in this regard. This study aimed to compare the 10-year incidence probability of CVD events and its associated risk factors between rural and urban areas in Iran.

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[Lu]Lu-DOTATATE is a newly trending acceptable therapy in recurrent/residual meningioma with good safety. However, recognizing any possible side effects in this special population would be helpful for better management and individualization of this useful treatment. Although the seizure has been previously reported in a few cases after [Lu]Lu-DOTATATE therapy in recurrent meningioma, the acute onset of seizure in these patients, early after therapeutic radioligand administration, is not reported to the best of our knowledge.

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Long non-coding ribonucleic acids (lncRNAs) have been implicated as possible circulating stroke indicators. This study focused on the expression status of antisense non-coding ribonucleic acid in the INK4 locus (ANRIL) and myocardial infarction associated transcript (MIAT) in patients with cerebral venous thrombosis (CVT). In this study, fifty patients with CVT and one hundred age/gender-matched individuals as controls were included.

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Knee osteoarthritis offers significant opportunities for prevention and the mitigation of its severity and associated symptoms through lifestyle modifications. This study aimed to investigate the efficacy of an educational intervention based on the Theory of Planned Behavior (TPB) in promoting preventive behaviors against knee osteoarthritis among women aged over 40 years residing in Fars, Iran. This research utilized a quasi-experimental design.

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Background: The relationship between inborn errors of immunity (IEIs) and COVID-19 severity and incidence rates remains unclear due to limited and diverse data. This study aimed to address this gap by identifying specific IEIs associated with an increased risk of severe COVID-19 or a predisposition to severe disease before vaccination.

Materials And Methods: Data were collected from the medical records of 15 patients with various IEIs, supplemented by interviews with individuals from an IEIs registry who had experienced COVID-19 before vaccination.

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Introduction: Hypertension (HTN) is a prevalent condition associated with numerous cardiovascular and non-cardiac complications. Lifestyle interventions, including dietary adjustments, offer promising avenues for hypertension management. However, the precise relationship between dietary antioxidants and hypertension risk necessitates further investigation.

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Objective: Today, air medical services play a key part in providing emergency medical services in accidents and disasters in many countries, including Iran. The present study aims to investigate the barriers to air medical services in accidents and disasters in Iran and suggest solutions to them.

Results: Analysis of the qualitative data resulted in extraction of 84 codes, which were classified into 13 subcategories and eventually into four themes, namely planning, management of resources, updating procedures, and empowerment of human resources.

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This perspective discusses the convergence of digital twin (DT) technology and on-the-chip systems as pivotal innovations in precision medicine, substantially advancing drug discovery. DT leverages extensive health data to create dynamic virtual patient models, enabling predictive insights and optimized treatment strategies. Concurrently, on-the-chip systems from the Carbon world replicate human biological processes on microfluidic platforms, providing detailed insights into disease mechanisms and pharmacological interactions.

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The antibiotic resistance and biofilm formation by bacterial pathogens has led to failure in infections elimination. This study aimed to assess the antibacterial and anti-biofilm properties of novel synthesized nitroimidazole compounds (8a-8o). In this study, nitroimidazole compounds were synthesized via the A3 coupling reaction of sample substrates in the presence of copper-doped silica cuprous sulfate (CDSCS).

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Milk and dairy products are an important source of essential nutrients for human health. However, contamination of these foods poses a significant public health concern. In this study, risk assessment of aflatoxin M1 (AFM1) exposure associated with the consumption of traditional milk and dairy products in Fasa, Fars Province, Iran, was carried out.

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Objective: This study aimed to explore the potential protective effects of adipose-derived mesenchymal stem cell secretome (ASE) on oxidative stress triggered by Bisphenol-A (BisA) exposure in testicular mitochondria and sperm quality of rats.

Methods: Testicular tissue mitochondria and sperms were exposed to BisA (8 μM) and ASE (50 or 100 μg). ∆Ψm (mitochondrial membrane potential), reactive oxygen species (ROS) levels, antioxidant biomarkers, and sperm parameters were measured.

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Introduction: Chronic wounds continue to pose a significant global challenge, incurring substantial costs and necessitating extensive research in wound healing. Our previous work involved synthesizing zein nanofibers embedded with 5 %, 10 %, and 15 % nano-curcumin (Zein/nCUR 5, 10, and 15 % NFs), and examining their physicochemical and biological properties. This study aims to explore the potential of these nanofibers in macrophage (MØ) polarization and wound healing.

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Article Synopsis
  • - c-MET, or hepatocyte growth factor receptor (HGFR), is a key protein linked to various types of solid tumors and is associated with poorer treatment outcomes due to its connection to therapeutic resistance and expression alongside PD-L1.
  • - Tumor cells and myeloid-derived suppressor cells (MDSCs) activate c-MET signaling through hepatocyte growth factor (HGF), which disrupts immune function by depleting crucial amino acids, ultimately creating an immunosuppressive tumor environment.
  • - The review discusses potential c-MET-targeted immunotherapies, such as CAR therapies and monoclonal antibodies, highlighting their promise in improving cancer treatment and the importance of understanding the underlying molecular mechanisms for developing effective
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Diabetic wounds pose a significant challenge in healthcare due to their complex nature and the difficulties they present in treatment and healing. Impaired healing processes in individuals with diabetes can lead to complications and prolonged recovery times. However, recent advancements in wound healing provide reasons for optimism.

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Article Synopsis
  • This research compared the effects of two ultrasonic bleaching methods (bath and horn) on sunflower oil regarding degradation of beneficial compounds like tocopherols and sterols, as well as oxidation levels.
  • The study found that both ultrasound methods led to greater reductions in these compounds compared to traditional bleaching methods, with the horn technique proving more effective.
  • Despite having lower power output, the horn sonicator caused higher degradation of nutrients and increased oxidation indices, indicating a more pronounced impact on oil quality when compared to bath sonication and conventional bleaching.
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The intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumors development. Changes in cell shape, metabolism, and gene expression linked to EMT facilitate tumor cell invasion, metastasis, drug resistance, and recurrence. So, a better understanding of the intricate processes underlying EMT and its role in tumor growth may lead to the development of novel therapeutic approaches for the treatment of solid tumors.

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Background: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease in human history and it is expected to surpass other causes of liver disease mortality by 2030. Therefore, finding an alternative way to diagnose steatosis in the early stage when imaging modalities are not available is crucial. This study decided to validate the optimal cut-off points and the sensitivity and specificity of the Fatty Liver Index (FLI) based on the Iranian population compared to ultrasonography.

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Effect of WhatsApp Messenger-based education on the knowledge of health ambassadors about home care for minor illnesses.

BMC Health Serv Res

November 2024

Department of Health Information Sciences, Faculty of Management and Medical Information Sciences, Kerman University of Medical Sciences, Kerman, Iran.

Background: In the digital era, virtual education has become one of the most effective educational methods, in which, the latest educational materials can be made available to people using social network platforms. Health ambassadors are mediators for transferring health-related knowledge to the public, so, they must be aware of various health topics, such as home care for minor illnesses. This study aimed to determine the effects of social media-based interventions (using WhatsApp) on the knowledge of health ambassadors concerning home care for minor illnesses.

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Background: It is widely recognized that obesity is characterized by a chronic low-grade inflammatory condition. In the context of childhood and adolescent obesity, there is also a noteworthy correlation with elevated levels of inflammatory markers. These markers signify a proinflammatory state that may have relevance to the development of MS.

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Dietary inflammatory potential and metabolic (dysfunction)-associated steatotic liver disease and its complications: A comprehensive review.

Clin Nutr ESPEN

November 2024

Division of Endocrinology and Diabetes, Medanta The Medicity, Gurugram 122001, Haryana, India. Electronic address:

Article Synopsis
  • - Metabolic (dysfunction)-associated steatotic liver disease (MASLD) is linked to metabolic syndrome and is driven by inflammation that leads to liver injury, heavily influenced by diet as a modifiable risk factor.
  • - Studies indicate a strong correlation between pro-inflammatory diets (measured by Dietary Inflammatory Index and Empirical Dietary Inflammatory Potential) and higher risk of MASLD, especially among males, but the role of body mass index (BMI) in this relationship remains inconsistent.
  • - The diet’s inflammatory potential may also connect to severe liver issues, like advanced fibrosis and liver cancer, but more rigorous research is needed to clarify these associations and improve dietary guidelines for managing MASLD.
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Background: With shared modes of transmission and clinical symptoms the convergence of COVID-19 and tuberculosis (TB) might lead to reduced diagnosis and detection of TB, which is challenging for healthcare systems already strained by the pandemic's reach.

Methods: This ecological study investigated the impact of the COVID-19 pandemic on TB surveillance over the first 2 years of the pandemic (March 2020 to February 2022) in southeastern Iran. Interrupted Time Series (ITS) analysis with the quasi-Poisson regression models was used to estimate the relative risk (RR) of TB diagnosis and treatment outcome counts, stratified by gender, case definition, involvement type, and treatment outcomes.

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Article Synopsis
  • * The most common protozoan identified in cancer patients was Blastocystis hominis (22.8%), followed by Giardia lamblia and others, while Cystoisospora belli and Cryptosporidium sp. were noted as opportunistic infections.
  • * Statistical analysis revealed significant differences in the prevalence of certain infections, such as Blastocystis hominis and Cystoisospora belli, between the two groups, highlighting the risks for immunocompromised patients undergoing chemotherapy.
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Ferroptosis, a cell death regulation process dependent on iron levels, represents a promising therapeutic target in cancer treatment. However, the scarcity of potent ferroptosis inducers hinders advancement in this area. This study addresses this gap by screening the PubChem database for compounds with favorable ADMET properties to identify potential GPX4 inhibitors.

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