378 results match your criteria: "Farwaniya Hospital[Affiliation]"

Nodular posterior scleritis is an uncommon inflammatory disorder of the eye characterized by nodular lesions that may be similar to other intraocular conditions such as choroidal melanoma, leading to diagnostic difficulties. This case report and literature review aims to evaluate the demographics, modalities, treatment, and outcomes of nodular posterior scleritis. We describe a 41-year-old female patient who presented with diminished vision in her left eye.

View Article and Find Full Text PDF

Hip osteoarthritis (OA) is a prevalent condition causing significant pain and disability. Platelet-rich plasma (PRP) intra-articular injections have emerged as a potential therapeutic option, but their efficacy is still debatable and their safety profile remains under-explored compared to standard treatments. This systematic review aims to evaluate the efficacy and safety of PRP injections in patients with hip OA by analyzing data from randomized clinical trials (RCTs).

View Article and Find Full Text PDF

Corrigendum: Genomic profiling of methicillin-sensitive (MSSA) isolates in Kuwait hospitals.

Front Microbiol

October 2024

Department of Microbiology, College of Medicine, Kuwait University, Kuwait City, Kuwait.

[This corrects the article DOI: 10.3389/fmicb.2024.

View Article and Find Full Text PDF

Hyaluronic acid (HA) injections are a generally safe procedure, primarily performed to achieve a more aesthetically appealing appearance. Despite the safety of HA filler procedures, complications may arise in some individuals, such as tenderness, lumpiness, swelling, bruising, neurological impairments, embolism, soft-tissue necrosis, irreversible scarring, and baldness. We present a case of a 36-year-old previously healthy female who was injected with HA filler (Juvederm Voluma®) into the nasolabial folds for cosmetic purposes.

View Article and Find Full Text PDF

Introduction: Increasing evidence from human and animal model studies indicates the significant role of microRNAs (miRNAs) in pancreatic beta cell function, insulin signaling, immune responses, and pathogenesis of type 1 diabetes (T1D).

Methods: We aimed, using next-generation sequencing, to screen miRNAs from peripheral blood mononuclear cells of eight independent Kuwaiti-Arab families with T1D affected siblings, consisting of 18 T1D patients and 18 unaffected members, characterized by no parent-to-child inheritance pattern.

Results: Our analysis revealed 20 miRNAs that are differentially expressed in T1D patients compared with healthy controls.

View Article and Find Full Text PDF

Purpose: The objective of this manuscript is to assess the effect of varicocele repair (VR) in patients with clinical varicoceles on serum total testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and inhibin B serum levels.

Materials And Methods: The study was performed in compliance with the Meta-Analysis and Systematic Reviews of Observational Studies (MOOSE) guidelines and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). All eligible studies were selected following the PICOS (Population, Intervention, Comparison/Comparator, Outcomes, Study design) model.

View Article and Find Full Text PDF

Background: Rheumatoid arthritis (RA) is a common condition treated with biological disease-modifying anti-rheumatic medicines (bDMARDs). However, many patients exhibit resistance, necessitating the use of machine learning models to predict remissions in patients treated with bDMARDs, thereby reducing healthcare costs and minimizing negative effects.

Objective: The study aims to develop machine learning models using data from the Kuwait Registry for Rheumatic Diseases (KRRD) to identify clinical characteristics predictive of remission in RA patients treated with biologics.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the differences in chronic kidney disease (CKD) management and characteristics between Kuwaiti citizens and expatriates, revealing that expatriates face restricted access to public health services and lower incomes, impacting their health outcomes.
  • - Data from 2,610 CKD patients showed that Kuwaitis were older with slightly lower kidney function (eGFR), but exhibited better blood pressure and diabetes control compared to expatriates, who had overall higher kidney function but poorer management of diabetes and hypertension.
  • - The conclusion emphasizes that CKD is predominantly caused by diabetes and hypertension, particularly in expatriates, and stresses the need for improved healthcare access, better treatment utilization, and more effective antihypertensive therapies for all patients.
View Article and Find Full Text PDF
Article Synopsis
  • - Hyperkalemia, a condition common in heart failure and kidney disease patients using RAAS inhibitors, complicates their treatment; new potassium binders like sodium zirconium cyclosilicate show promise for managing this issue.
  • - A panel of twelve experts from Kuwait used a modified Delphi method to reach a consensus on hyperkalemia management, resulting in 44 statements covering treatments for acute cases, heart failure, chronic kidney disease, and hemodialysis.
  • - The consensus highlights the inconsistencies in current management guidelines and aims to provide standardized guidance for healthcare practitioners in Kuwait, addressing the treatment gaps in the Arabian Gulf region.
View Article and Find Full Text PDF
Article Synopsis
  • Varicella zoster virus (VZV) causes chickenpox (primary varicella infection) and shingles (herpes zoster) and can lead to serious conditions like varicella pneumonia, particularly in adults.
  • The text discusses two adult male cases of primary varicella with complications, where one patient exhibited respiratory symptoms and both showed signs of pneumonia on chest X-rays.
  • Prompt treatment with intravenous acyclovir significantly improved their conditions, emphasizing the need for early detection and vaccination to prevent severe outcomes from VZV-related complications.
View Article and Find Full Text PDF
Article Synopsis
  • Percutaneous coronary intervention (PCI) is primarily guided by coronary angiography, but there's growing interest in using advanced tools like optical coherence tomography (OCT) for better guidance.
  • *OCT offers high-resolution images that provide detailed information about coronary lesions and how to optimize PCI, but its use in routine practice is still not widespread.
  • *Factors limiting OCT's adoption include the shift from intravascular ultrasound, the skill required for using and interpreting OCT, the absence of a standardized approach for its application, and insufficient clinical evidence to support its routine use.
View Article and Find Full Text PDF

There has been much controversy about the true value of varicocele repair for improving fertility and the chances of natural conception. This review summarizes the latest research findings, current professional societies' recommendations, and the conclusions of recent systematic reviews and meta-analyses. The current evidence suggests a positive role for varicocele repair in improving basic sperm parameters and increasing the likelihood of natural pregnancy.

View Article and Find Full Text PDF
Article Synopsis
  • Soft tissue sarcoma, although rare, should be considered when evaluating masses in the head and neck regions, requiring careful assessment.
  • A patient with a suspected intermuscular lipoma in the neck underwent imaging, which indicated a large fatty mass, but post-surgery, it was diagnosed as a well-differentiated liposarcoma after histopathological examination.
  • The case highlights the importance of thorough diagnosis and treatment strategies for conditions that can be misidentified, showcasing the details involved in the surgical approach to remove the mass.
View Article and Find Full Text PDF

Purpose: In this systematic review and meta-analysis, we investigated assisted reproductive technology (ART) success in infertile men with clinical varicocele and abnormal semen parameters who underwent varicocele repair (VR) before the ART procedure as compared to those who did not.

Materials And Methods: A comprehensive search of the Scopus, PubMed, Embase, and Cochrane Library databases was conducted using a specific query string to identify studies examining the impact of VR on ART outcomes, including fertilization rate, clinical pregnancy, pregnancy loss, and live-birth rate, until October 2023. Outcomes were analyzed based on the type of ART.

View Article and Find Full Text PDF
Article Synopsis
  • Surgical sperm retrieval (SSR) is performed to extract sperm from men with azoospermia and may result in reduced testosterone levels and other hormonal changes post-operation.* -
  • A systematic review analyzed 17 studies involving 1,685 azoospermic men, revealing a significant decrease in testosterone after SSR, but no major changes in follicle-stimulating hormone (FSH), luteinizing hormone (LH), or testicular volume.* -
  • The study highlights the importance of considering potential sexual dysfunction and the psychosocial impacts of SSR in postoperative care and preoperative discussions.*
View Article and Find Full Text PDF
Article Synopsis
  • Recent outbreaks of multidrug-resistant fungi in healthcare settings highlight the need for effective antifungal susceptibility testing (AST) to manage invasive infections.* -
  • The study compared the performance of Etest and broth microdilution-based MICRONAUT-AM-EUCAST assays by testing 121 clinical isolates, revealing significant discrepancies in fluconazole and amphotericin B resistance assessments.* -
  • Findings suggest that MCN-AM underestimates fluconazole resistance, while Etest overestimates amphotericin B resistance, indicating a need for method-specific resistance breakpoints to improve clinical outcomes.*
View Article and Find Full Text PDF
Article Synopsis
  • Oral lichen planus (OLP) is a potentially serious condition of the mouth, and this study explores the potential of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) as alternatives to corticosteroids for treatment.
  • A systematic review of existing randomized controlled trials was conducted, analyzing data from 8 studies involving 157 patients to compare PRP and PRF against corticosteroids based on changes in lesion size, pain, and clinical scores.
  • The findings indicate no significant differences between PRF, PRP, and corticosteroids in most outcomes, but PRF consistently ranked highest in reducing lesion sizes and pain scores at various weeks, suggesting it could be a more effective treatment alternative in managing OLP.
View Article and Find Full Text PDF
Article Synopsis
  • This study is the first to examine out-of-hospital cardiac arrest (OHCA) in Bahrain, revealing an annual incidence of about 21 cases per 100,000 people, predominantly affecting older males.
  • The research found that most cases were witnessed and occurred at home, but bystander CPR and AED usage were significantly low, leading to poor survival rates.
  • The results highlight the urgent need for improved community training in CPR and AED usage, better EMS evaluation, and the establishment of an OHCA registry to enhance outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the incidence and outcomes of acute kidney injury (AKI) in Kuwait, focusing on differences between Kuwaiti and non-Kuwaiti patients, who face limited access to healthcare.
  • A total of 3,744 adult inpatients with AKI were analyzed from seven public hospitals in 2021, revealing that non-Kuwaitis were younger, had better kidney function at baseline, and a higher rate of AKI caused by community factors.
  • Despite differences in demographics, there were no significant variations in mortality or kidney recovery rates between the two groups, with a high overall mortality rate of 34.4% among AKI patients within 30 days of hospitalization.
View Article and Find Full Text PDF
Article Synopsis
  • * The World Health Organization's "One-Health" approach emphasizes the need to assess ARGs in the environment to combat AMR's development and spread.
  • * New research highlights the role of aerosols from wastewater treatment plants, hospitals, and livestock facilities in disseminating AMR, signaling a need for ongoing monitoring and health advisories for affected communities.
View Article and Find Full Text PDF
Article Synopsis
  • In gastrointestinal stromal tumors (GISTs), identifying specific genetic mutations is crucial for predicting treatment responses and disease outcomes.
  • In a study of 95 GIST cases from the Kuwait Cancer Center, a significant majority (88%) had mutations, with most occurring in the gene, highlighting the need for targeted treatments.
  • Wild-type GISTs (without mutations) appeared to be smaller and less aggressive, but their impact on disease progression was minimal, underscoring the importance of further regional studies to connect genetics with patient outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • - The case discusses a 33-year-old female with posterior disc displacement (PDD) in the temporomandibular joint (TMJ), characterized by persistent pain and restricted mouth opening due to idiopathic factors.
  • - The diagnosis confirmed bilateral non-reducible PDD, and the treatment approach was open TMJ surgery (Discopexy) aimed at releasing and mobilizing the affected discs.
  • - Post-surgery, the patient experienced significant improvement in mouth opening and relief from pain, highlighting the effectiveness of MRI for diagnosis and the benefits of a specific surgical incision in reducing complications.
View Article and Find Full Text PDF
Article Synopsis
  • More people are getting serious infections from certain fungi, like Aspergillus and Mucorales, and this is happening more often in recent years.
  • Isavuconazonium sulfate, also called isavuconazole, is a new type of medicine that can help treat these infections and works well for patients who might not respond to other medicines.
  • While it's not yet proven to prevent these infections, some real-life cases show that it can be useful for patients who are at risk and can’t use other treatments.
View Article and Find Full Text PDF

Genomic profiling of methicillin-sensitive (MSSA) isolates in Kuwait hospitals.

Front Microbiol

July 2024

Department of Microbiology, College of Medicine, Kuwait University, Kuwait City, Kuwait.

Article Synopsis
  • The study investigates methicillin-susceptible Staphylococcus aureus (MSSA) in Kuwaiti hospitals to analyze antibiotic resistance and genetic backgrounds of isolates from 2016 and 2021.
  • A total of 446 MSSA isolates were collected, showing resistance to several antibiotics, particularly erythromycin and ciprofloxacin, while being uniformly susceptible to vancomycin and other key antibiotics.
  • Diversity in genetic backgrounds was revealed, with several clonal complexes identified, particularly CC1, CC15, and CC22, indicating stable MSSA clones in the hospital over the study periods.
View Article and Find Full Text PDF

Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder characterized by deficient or absent -L-iduronidase (IDUA) enzyme activity due to pathogenic variants in the gene. Early treatment with hematopoietic stem cell transplantation and/or enzyme replacement therapy is associated with improved outcomes in this progressive multisystem disease. The diagnosis is usually delayed due to late presentation and non-specific symptoms, which result in high morbidity and mortality.

View Article and Find Full Text PDF