[Medicinal cannabis: beyond the myth, just another (herbal) drug].

This editorial briefly explores some of the distinctions between drugs and pharmaceuticals, alongside definitions regarding Cannabis sativa and its use in the context of a newly legal industry. Furthermore, medical cannabis is considered with regard to its toxicity, its social uses, its pharmacological activity, its legal paradoxes, and the scientific revolution sparked by the study of the endocannabinoid system, which has gained a great deal of relevance for modern physiology and pharmacology.

Incidence and characteristics of falls in hospitalized patients: A cohort study.

Objective: To estimate the incidence of falls and to know their characteristics in terms of location, temporality and injuries produced, and to analyse the sociodemographic and clinical characteristics of the patients who suffer falls.

Methodology: A retrospective observational cohort study was carried out in a level 2 hospital of the Madrid Health Service. Falls in hospitalized patients between July 1, 2018 and June 30, 2019 were studied.

[Oral antibiotic request without prescription in community pharmacies. Description of pharmacists' intervention].

Objectives: To quantify the proportion of oral antibiotics requests without prescription in Community Pharmacy (CP) and to analyse it causes.

Method: Cross-sectional multicentre study carried out in Spanish community pharmacies during 4 weeks, one in each season of the year. Oral J01 antibiotics (Anatomical Therapeutic Chemical classification, ATC) requested for self-medication were analysed.

[Primary care, residential homes for the elderly, and COVID-19].

Rest homes for the elderly have been particularly hit during the crisis due the current COVID-19 pandemic. At the time of writing this article, more than 17,500 elderly people that lived in Care Homes have died due to coronavirus, more than 66% of the deaths. The infection and mortality rates in the institutionalised population are high.

[Characteristics of private and irregular prescription for oral antibiotics in Spanish community pharmacies].

Objective: To quantify the proportion of oral antibiotics through private prescription (PP) and irregular prescription (IP) in the Community Pharmacy (CP).

Material And Methods: Cross-sectional multicentre study carried out in Spanish community pharmacies over a 4week period, one in each season of the year. An analysis was made of private and irregular prescriptions of oral J01 antibacterials for systemic use (Anatomical Therapeutic Chemical [ATC] classification).

[Platelet-rich plasma: updating of extraction devices].

Unlabelled: Propose: To describe PRP extraction devices, through a review of kits available in Spain, taking into account AEMPS and SEFH working groups (GPS, Farmacotecnia, Hemoderivados groups) contributions.

Methods: Three independent searches about PRP extraction devices were carried out. Device suppliers were contacted and an individually meeting was called with each one.

[Vancomycin intoxication in a patient with inappropriate antidiuretic hormone syndrome and diarrhea].

Vancomycin is an antibiotic used for infections by gram-positive bacteria with a two-compartment pharmacokinetic model. Its monitoring has an established therapeutic range (10-20 mg/L) to prevent nephrotoxicity and ototoxicity due to supratherapeutic levels, and inefficiency and development of resistance by subtherapeutic levels. Nephrotoxicity for vancomycin monotherapy at standard doses according to pathogen and typical regimens (usual dose: 15-20 mg/kg/12 h) is rare and usually reversible.

[Methods to obtain platelet-rich plasma and osteoinductive therapeutic use].

Introduction: Platelet-Rich Plasma (PRP) is autologous plasma with higher concentration of platelet than basal level, because of an extracting and concentration process. PRP therapeutical use, as osteinductor role, is a controversial issue, due to there are no clinical studies with rigorous design and no firm conclusions can be drawn regarding its uses. Propose: To provide information about methods to obtain PRP, legal considerations about its extraction and use, molecular mechanism of action, as well as available evidence about security and tolerance.

[Prevention of medication errors in healthcare transition of patients treated with apomorphine].

The transition of patients between different levels of care process is a particular risk in the production of medication errors. The aim of this paper is to analyze the role of the pharmacist in preventing errors transition care to ensure a safe and cross pharmacotherapy of patients.Transversal, observational and descriptive study in a University Hospital that has a pharmacy service that integrates specialized inpatient care and health centers.

[Thermolabile drugs stability faced with an accidental interruption in the cold chain].

Objective: To develop an updated guide about the stability of thermolabile drugs included in the Pharmacotherapeutic Guide that,according to product information sheet, should be stored under refrigeration or freezing, when are accidentally exposed to temperatures outside the range recommended by the manufacturer.

Methods: It was reviewed the information about storage temperatures recommended in the product information sheet and the available stability data at different temperatures of thermolabile drugs included in the Pharmacotherapeutic Guide of a 400-bed hospital that, according to the manufacturer, should be stored under refrigeration or freezing. Drugs of clinical trials were excluded.

[Optimisation of pharmacotherapy in a trauma centre].

Objective: To evaluate the results for implementing a pharmaceutical care programme aimed at optimising personalised pharmacotherapeutic treatment in a Trauma Centre with electronic medical records (EMR) and an integral system for personalised medication dispensing (ISPMD).

Method: A three-year observational, retrospective study (2007-2009). On a daily basis, we checked the pharmaceutical treatment of patients admitted to hospital units with ISPMD.

[Detection of therapeutic non-compliance and pharmaceutical intervention in institutionalised geriatric patients].

Objective: To detect and analyse therapeutic non-compliance in the institutionalised elderly patient who self-administer their own treatment in a geriatric residence. To assess the pharmaceutical intervention with a useful tool to detect non-compliance.

Material And Methods: An observational study on a population of 386 residents.

Probabilistic cost-minimisation analysis of darbepoetin alpha versus epoetin alpha in treating anaemia secondary to chronic renal failure. Assessment in Spanish clinical practice.

Introduction: The direct transfer of the results of pharmaco-economic studies between countries may not be suitable if the proper adaptations are not made to take into account differences in treatment patterns, resource use and costs from country to country.

Objective: To estimate the cost in Spain of treating anaemia secondary to chronic renal failure with darbepoetin alpha or epoetin alpha from a review and analysis of available current information. In addition, the role of the route of administration as a main driver of the cost will be analysed.