454 results match your criteria: "Farhat HACHED University Hospital[Affiliation]"

Background: To assess the contribution of ultrasound in diagnosing occupational carpal tunnel syndrome (CTS), compare it with electromyography (EMG) results, and evaluate the ultrasound characteristics of CTS patients.

Methods: A nine-month cross-sectional study (January-September 2021) involved CTS patients and a control group, utilizing a structured form for data collection. EMG was performed on the patient group ('cases') and ultrasound examinations were conducted on both groups.

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Background: Cutaneous Leishmaniases (CL), highly endemic in Africa and Mediterranean region, are caused by different Leishmania parasite species. Accurate species identification is crucial for effective diagnosis, treatment, and control of these diseases, but traditionally relies on DNA-based methods. High Resolution Melting analysis PCR (HRM PCR) provides rapid results and precise differentiation based on nucleotide variations.

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The Horoscope trial aimed to assess the efficacy of home blood pressure (BP) telemonitoring (TLM) in controlling BP reduction in hypertensive patients compared with usual care. This is a multi-center, prospective randomized, parallel-group trial comparing TLM with usual care during a period of 6 months in patients with hypertension. We included 525 patients randomly assigned in a 1-1 ratio to telemonitoring (TLM group; n = 260) or usual care (control group; n = 265).

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Genetic Insights Into Epidermolysis Bullosa: Identification of Novel Variants in Tunisian Patients.

Am J Med Genet A

December 2024

Laboratory of Human Cytogenetics, Molecular Genetics, and Reproductive Biology, Farhat Hached University Hospital, University of Sousse, Sousse, Tunisia.

Epidermolysis Bullosa (EB) is a group of genetic skin disorders characterized by extreme skin fragility and blistering. In North African countries, including Tunisia, complex genetic and phenotypic diversity is entangled with a scarcity of scientific research on EB. This lack of knowledge presents a distinct challenge in terms of diagnostic accuracy and patient care.

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Purpose: Orotracheal intubation is one of the most frequently used techniques in emergency procedures and especially in anesthesia and resuscitation. Teeth may be "victims" of the orotracheal intubation. Several factors may predispose to these accidents.

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Article Synopsis
  • Schizophrenia (SZ) may have an autoimmune aspect, as indicated by higher levels of antiphospholipid antibodies in patients compared to healthy individuals.
  • * The study analyzed serum samples from 80 drug-free SZ patients and 80 matched controls, finding significantly elevated aCL-IgM, aCL-IgA, and aβ2GPI-IgA levels in SZ patients.
  • * These findings suggest a potential autoimmune link in SZ, warranting further research into the role of these antibodies in the disease's development and their connection to antiphospholipid syndrome.
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Electronic Health Records (EHR) have been adopted to improve the quality of care. Despite the growing use of health information technology, nursing documentation remains a challenge. In Tunisia, the implementation of the Electronic Medical Record (EMR) system is gaining momentum as part of national initiatives to modernize healthcare.

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Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry.

Joint Bone Spine

November 2024

Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy. Electronic address:

Article Synopsis
  • The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
  • A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
  • Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
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Introduction And Importance: Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder characterized by painless lymph node enlargement and extranodal involvement. This disease often presents diagnostic challenges due to its variable clinical manifestations and the need for histologic confirmation.

Case Series Presentation: This case series examines five patients diagnosed with Rosai-Dorfman disease who presented with a variety of clinical manifestations.

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Introduction: Cleft lip and palate (CLP) is the most common congenital malformation of the head and neck. Children with CLP often exhibit dental anomalies.

Aim: To evaluate the dental age (DA) of unilateral CLP in Tunisian children.

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Due to the increasing resistance prevalence to the last line of antibiotics, such as colistin, and the rising threat of multi-drug resistant bacteria, it is crucial to find alternative therapeutic options. The current study focuses on evaluating antibacterial activities alone and in combination with colistin of essential oil (TA-EO) against colistin-resistant , , and co-harboring -1 gene. GC/MS was used to determine the chemical composition of TA-EO.

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Weight perception and mental health disorders among adolescents of central-eastern Tunisia: A cross-sectional study.

PLoS One

October 2024

Department of Epidemiology, "LR19SP03", Faculty of Medicine of Sousse, Farhat Hached University Hospital, University of Sousse, Sousse, Tunisia.

Background: The physical changes that accompany the onset of puberty demand a constant restructuring of the adolescent's perception of their body and may influence adolescents' mental health.

Aim: To describe weight status perception and its association with socio-demographic characteristics (SDC) and mental health disorders among adolescents in a low and middle-income country (LMIC).

Methods: We conducted a cross-sectional study in high schools in the urban area of the governorate of Sousse, Tunisia in 2018.

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Introduction And Importance: Cystic lesions of the parotid gland are uncommon, comprising approximately 5 % of all salivary gland tumours. Among these, epidermoid cysts are particularly rare. These benign developmental cysts typically manifest in the skin of the scalp, face, and neck, but are rarely observed in the parotid gland.

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Introduction: The management of healthcare waste is a crucial issue for public health and the environment. To minimise risks, it is essential to ensure that the management of healthcare waste is meticulously applied. Additionally, among the evaluation methods adopted by the hospital hygiene department to monitor the degree of compliance.

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Background: Leishmaniasis is responsible for approximately 65,000 annual deaths. Various Leishmania species are the predominant cause of visceral, cutaneous, or mucocutaneous leishmaniasis, affecting millions worldwide. The lack of a vaccine, emergence of resistance, and undesirable side effects caused by antileishmanial medications have prompted researchers to look for novel therapeutic approaches to treat this disease.

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Introduction: Telemedicine encompasses all medical practices that allow patients to be remotely cared for through new information and communication technologies. This study aims to assess the remote management of patients consulting emergency services and not requiring in-hospital care during both pre-pandemic and pandemic periods of COVID-19.

Methods: This was a prospective, randomized, controlled study.

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Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study.

Int J Infect Dis

October 2024

Gulhane School of Medicine, Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Ankara, Türkiye.

Article Synopsis
  • This study analyzed 331 patients with primary brain abscesses (PBAs) from 39 centers in 16 countries, focusing on infection causes, risk factors, and mortality outcomes over a 12-year period.
  • Study results showed that the majority of patients were middle-aged men (average age 46.8), with symptoms like headaches and fever; Gram-positive cocci were the most common pathogens.
  • Key factors influencing mortality at 42 days included intravenous drug use and malignancy, while factors affecting 180-day mortality included temporal lobe involvement and the presence of unidentified bacteria.
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Colorectal Cancer Detection during a Screening Awareness Campaign in a High-Risk Region in Oman.

Asian Pac J Cancer Prev

August 2024

LR21ES03 Research Laboratory, Oncogenesis and Tumor Progression, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.

Article Synopsis
  • * The awareness campaign took place in South Ash Sharqiyah Governorate from January to March 2023, involving 688 participants aged over 40 to collect survey data and conduct fecal occult blood tests (FOBTs) and colonoscopies.
  • * Results showed a 68.8% screening response rate, with 8.1% testing positive for FOBTs, primarily in individuals aged 40-59 and those who were overweight; one participant was diagnosed with stage I CRC, highlighting the importance of early detection efforts.
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Genome Tunisia Project: paving the way for precision medicine in North Africa.

Genome Med

August 2024

Laboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia.

Article Synopsis
  • The Genome Tunisia Project is a two-phase initiative (2022-2035) aimed at sequencing the Tunisian Genome and advancing personalized medicine in Tunisia, a diverse North African country affected by human migration patterns from various continents.
  • A multidisciplinary team of Tunisian experts is focused on addressing key priorities, such as determining the reference genome sequence, enhancing education and awareness, and improving infrastructure for personalized medicine integration.
  • The project involves collaboration among various stakeholders, including healthcare providers and policymakers, and aims to boost research and innovation in genomics while improving healthcare practices in the region.
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Sleep Habits and Disturbances Among Tunisian Adults: A Cross-Sectional Online Survey [Response to Letter].

Nat Sci Sleep

August 2024

Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital of Sfax, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.

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Introduction: Identifying heart failure (HF) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) can be challenging. Lung ultrasound sonography (LUS) B-lines quantification has recently gained a large place in the diagnosis of HF, but its diagnostic performance in AECOPD remains poorly studied.

Purpose: This study aimed to assess the contribution of LUS B-lines score (LUS score) in the diagnosis of HF in AECOPD patients.

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As one of the key tools on the precision medicine workbench, high-throughput genetic testing has enormous promise for improving healthcare outcomes. Tunisia has made tremendous progress in acquiring and implementing the technology in the clinical context. However, current utilization does not ensure the whole range of benefits that high-throughput genomic testing provides which impedes the country's ability to move forward into the new era of precision medicine.

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