[Diabetic retinopathy and pregnancy].

This article reviews the critical issue of diabetic retinopathy (DR) in pregnant women with diabetes mellitus (DM), and describes the current understanding of the features of DM progression during pregnancy, as well as its pathogenic mechanisms, risk factors, and preventive measures for manifestation and progression of DR during gestation.

Fatal bear attack in Russian Federation: A case report.

Human-bear conflicts are a growing concern globally, with Russia harboring a significant population of brown bears. This case report details a fatal encounter between a male hunter and a brown bear in the greater Khabarovsk region. On October 2015, the hunter's body was discovered approximately 400 m from a deceased brown bear, indicating a deadly confrontation.

[Risk factors associated with myopic maculopathy in acquired myopia].

Purpose: This study aimed to identify factors associated with the development of myopic maculopathy (MM) in patients with acquired myopia.

Material And Methods: The study included a total of 135 patients (41 men, 94 women; 135 eyes) over 30 years old with acquired myopia and axial length (AL) of 26 mm. Forty-six patients had MM, while 89 (66%) had no macular changes.

Effect of Experimental Litter Reduction on Cerebellum Development in Suckling Rats.

We studied morphological features of the cerebellum in 14-day-old Wistar rats from reduced litters (the number of pups was reduced from 10-12 to 6 on the next day after birth). The control group comprised 14-day-old animals from litters of medium size (10-12 rat pups). Rats from reduced litters had greater body weight and brain weight.

[Clinical and laboratory features of rheumatoid arthritis in men depending on testosterone levels].

Background:  It has been suggested that the presence of chronic immunoinflammatory rheumatic disease (CIRD) may be a factor that increases the likelihood of developing hypogonadism syndrome, and conversely, the presence of uncompensated testosterone deficiency may predispose to a greater risk of developing or more severe course of ICRD.

Aim:  To study the incidence of hypogonadism in men with rheumatoid arthritis (RA) and evaluate its impact on the course of RA and concomitant diseases.

Materials And Methods:  A one-time continuous study included 170 men with RA who were undergoing inpatient treatment at the Federal State Budgetary Institution NIIR named after.

Trends in childhood leukemia incidence in urban countries and their relation to environmental factors, including space weather.

Leukemia is the most common cancer in children. Its incidence has been increasing worldwide since 1910th, suggesting the presence of common sources of the disease, most likely related to people's lifestyle and environment. Understanding the relationship between childhood leukemia and environmental conditions is critical to preventing the disease.

[Fatal injury to the neck while working with an angle grinder].

A fatal accident using an angle grinder is presented. During the forensic medical examination of the corpse, a soft tissue wound of the neck was found, localized in the region of its anterior and right lateral surfaces, with damage to the common carotid artery, internal jugular vein, sternocleidomastoid and sternothyroid muscles, thyroid lobe, incomplete transection of the trachea and esophagus caused by the rotating disc of an angle grinder. This observation supplements the existing ideas about injuries caused by power tools, as well as the possibility of reconstructing an event based on a comprehensive assessment of data from the scene.

Effects of Non-Opiate Analogue of Leu-Enkephalin on the Ion Currents, Number of Nucleoli, and p53 Expression in Isolated Cardiomyocytes of Albino Rats.

Acute exposure of isolated ventricular cardiomyocytes to non-opiate analogue of leu-enkephalin (NALE peptide: Phe-D-Ala-Gly-Phe-Leu-Arg) in a concentration of 100 μg/liter and 6-h incubation in NALE solution did not significantly change ATP-dependent K current, L-type Ca current, p53 protein expression, and number of nucleoli in the cardiomyocyte nuclei. Incubation of cardiomyocytes with NALE (100 μg/liter) in combination with NOP receptor blocker J-113397 (1 mg/liter) was followed by an increase in Ca L-type current and the number of p53 cells. The exposure of cardiomyocytes to NALE in a concentration 1000 μg/liter induced similar changes in the studied parameters (increase in Ca L-type current and number of p53 cardiomyocytes); an increase in the mean number of nucleoli was also observed.

[The distinc features of a blood drip stain on a surface covered with house dust].

The purpose of the investigation is to establish the characteristics of a blood drip stains on a surface covered with house dust. In most cases, objects at the crime scene are covered in some degree of dust deposits. Accordingly, in external bleeding wounds, blood drops on dusty surfaces.

Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Management.

Background And Aims: Several methods are available to diagnose infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe.

Methods: The European Registry on the management of infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of -infected patients in Europe.

[The Soviet health care: in searching unicorn].

The article review the book about the Soviet health care. The analysis of its content and main conclusions is presented. The book inflicts powerful blow on myth of numerous merits, achievements, progressiveness, impeccability and humanity of the Soviet health care.

[Bilateral uveitis associated with protein kinase inhibitor-based treatment of skin melanoma (case study)].

The article presents a clinical case of bilateral uveitis with macular edema that developed during long-term administration of vemurafenib. Methods of conservative treatment of malignant tumors are presently available and reasonably effective. However, at the same time drugs can have toxic effect on normal cells in various tissues of the body.

[Investigation of diabetic retinopathy progression in women with diabetes mellitus during pregnancy].

Purpose: The study evaluates the transient and stationary diabetic retinal changes in pregnant women with diabetes mellitus (DM) based on the analysis of individual clinical cases of diabetic retinopathy (DR) progression.

Material And Methods: The study examined 24 pregnant women with DM. The examination was carried out in each trimester of pregnancy and 6 months after delivery.

Estimation In Vivo of the Antioxidant Activity of Axillary-Blueberry ( Nakai) Fruit under Oxidative Stress.

The intensity of free radical oxidation processes in vivo (a model of induced oxidative stress) was studied after a probe administration of the fruit extract of the axillary blueberry ( Nakai). Four groups ( = 40) of white CBA line male mice weighing 20-25 g were involved in the experiment: (1) intact control; (2) introduction of a 0.9% sodium-chloride solution orally for 10 days, a dose of 10 mL/kg per day; (3) "cisplatin" group (animals received 0.

[Effectiveness of empirical eradication therapy with furazolidone in Russia: results from the European Registry on Management (Hp-EuReg)].

Background: First-line therapy does not always provide a high level of eradication due to the increase of resistance to antibiotics; therefore, it remains necessary to identify the most effective rescue treatments. The purpose of this study was to evaluate the efficacy and safety of empirical furazolidone-containing regimens.

Materials And Methods: Adult infected patients empirically treated with furazolidone-containing eradication regimens were registered in an international, prospective, multicenter non-intervention European registry on management (Hp-EuReg).

[Evaluation of the clinical efficacy of the effect of herbal medicine on the symptoms of SARS-COV-2 associated pharyngitis and the formation of post-covid syndrome].

Pharyngitis is one of the manifestations of SARS-CoV-2 infection, which features specific changes in the pharyngoscopic pattern, long fluctuating course and increase in symptoms severity after a physical exercise, which requires long-term therapy with topical agents. A comparative analysis of Tonsilgon N effect on the course of SARS-CoV-2 associated pharyngitis as well as post-COVID syndrome development was carried out in this study. 164 patients with acute pharyngitis associated with SARS-CoV-2 were included in the study.

[The stomatological care of schoolchildren in the Soviet Russia in 1920s: Succession of ideas].

The article considers historical interaction between the Soviet Russia and the Weimar Republic related to prevention of caries in children in 1920s and the role of P. G. Dauge in it.

[Occurrence of myopic maculopathy in eyes with staphylomas of various localization].

Unlabelled: Complicated myopia develops in young people of working age, of which about 30% subsequently become visually impaired. Formation of ocular staphyloma affects the macula causing myopic maculopathy, which leads to significant and irreversible decrease in visual functions.

Purpose: To study the occurrence frequency of various forms of myopic maculopathy in scleral staphylomas of different localization in patients with pathologic myopia.

Problems of purchasing pharmacy products through online orders.

Online pharmacy services and online ordering of pharmaceutical products are in demand, especially in the context of the COVID-19 pandemic. The problems of the purchase of pharmacy products through online orders in the Far Eastern Federal District were analyzed. Sociological survey of the population ( = 3789) was carried out.

[Anatomical and morphometric features of anterior eye segment structures in hyperopia and the risk of developing primary angle-closure glaucoma].

Purpose: To study features of anatomical and morphometric parameters of the structures of anterior eye segment in young patients with moderate and high hyperopia in order to identify the signs of an increased risk of developing primary angle-closure glaucoma (PACG) and its acute attack.

Material And Methods: The study included 160 eyes (80 patients) with axial length (AL) of less than 23 mm. Patients with moderate or high hyperopia were divided into two groups according to their age ranges (the 1 - 27 patients (54 eyes) under 40 years old; the 2 - 27 patients (54 eyes) of 41-50 years old, the comparison group - 26 patients (52 eyes) of 42-50 years old with the initial stage of PACG.

[Prospects for personalized Helicobacter pylori eradication therapy. Pro et contra].

The article is devoted to debatable aspects of Helicobacter pylori eradication therapy. The eradication cancer-preventive effects are considered. A negative comorbidity between H.