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Reaffirming Adverse Events Related to Lung Cancer Survivors' Target Therapies and Their Apparent Effects on Fear of Cancer Progression, Anxiety, and Depression.

Cancer Nurs

December 2022

Author Affiliations: Department of Nursing, National Taiwan University Hospital (Mrs Yu, and Drs Lai and Lee); Department of Dermatology, National Taiwan University Hospital, National Taiwan University College of Medicine (Dr Chu); School of Nursing, College of Medicine, National Taiwan University (Drs Lai and Lee); and Department of Nursing, National Taiwan University Cancer Center (Dr Lai), Taipei; Department of Nursing, Mackay Medical College (Dr Hung and Ms Chan), New Taipei City; Department of Nursing, Da-Yeh University (Dr Chen), Changhua; and Department of Dermatology, Far Eastern Memorial Hospital (Dr Hsu), New Taipei City, Taiwan.

Background: Most advanced non-small-cell lung cancer (NSCLC) patients received targeted therapies of epidermal growth factor receptor tyrosine kinase inhibitors. However, few studies reported the relationships between adverse events (AEs) and psychological distress.

Objectives: The aims of this study were to (1) examine the differences in the incidence of AEs, fear of progression (FoP), anxiety, and depression among 3 generations of epidermal growth factor receptor tyrosine kinase inhibitors (first, gefitinib and erlotinib; second, afatinib; third, osimertinib) and (2) examine the difference in levels of FoP, anxiety, and depression between the presence and absence of AEs in NSCLC patients.

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