Is There a Role for Risk-Reducing Bilateral Breast Surgery in Ovarian Cancer Survivors? An Observational Study.

Background: Risk-reducing surgeries are an option for cancer risk management in individuals. However, while adnexectomy is commonly recommended in breast cancer (BC) survivors, risk-reducing bilateral breast surgery (RRBBS) is controversial in ovarian cancer (OC) survivors due to relapse rates and mortality.

Methods: We conducted a retrospective analysis of -OC survivors, with OC as first cancer diagnosis.

Challenges and Considerations on Risk-Reducing Surgery in Patients with Advanced Breast Cancer.

Cancer survivors harboring inherited pathogenic variants in the breast cancer (BC) susceptibility genes or are at increased risk of ovarian cancer (OC) and also of contralateral BC. For these women, risk-reducing surgery (RRS) may contribute to risk management. However, women with locally advanced or metastatic breast cancer (ABC) were excluded from clinical trials evaluating the benefit of these procedures in the carriers, and thus, current guidelines do not recommend RRS in this specific setting.

germline variants and male breast cancer.

Male breast cancer is rare and has been frequently associated with cancer predisposing variants, particularly in and genes. pathogenic variants may also increase risk for breast and other cancers. However, less than 10 cases relating mutations and male breast cancer have been previously reported.

Colorectal cancer surveillance in Portuguese families with lynch syndrome: a cohort study.

Purpose: Lynch syndrome (LS) is associated with a high risk of colorectal cancer (CRC). The aim of this study was to assess the cumulative risk for the development of colorectal adenomas or carcinomas in a LS CRC surveillance program and to audit the quality of the endoscopic procedures.

Methods: We evaluated 147 asymptomatic LS mutation carriers, without previous CRC, in a surveillance program with colonoscopy every 12-18 months, between 2005 and 2016.

Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities.

Serrated polyposis (SPP) is characterized by the development of multiple serrated polyps and an increased predisposition to colorectal cancer (CRC). In the present study, we aimed to characterize, at a clinical and molecular level, a cohort of SPP patients with or without a family history of SPP and/or polyps/CRC (SPP-FHP/CRC). Sixty-two lesions from 12 patients with SPP-FHP/CRC and 6 patients with sporadic SPP were included.