4,683 results match your criteria: "Fallopian Tube Disorders"
Unlabelled: Currently, chronic salpingo-oophoritis (CS) is still an urgent problem in the statistics of diseases of the female genital organs. In 35% of women, its course leads to disorder of the fallopian tubes patency and infertility. An additional indirect mechanism of infertility can be the morpho-functional failure of the endometrium.
View Article and Find Full Text PDFPersistent Müllerian Duct Syndrome with Supernumerary Testicles Due to a Novel Homozygous Variant in the Gene and Literature Review.
Diagnostics (Basel)
November 2024
Endocrinology Department, Elias Emergency University Hospital, 011461 Bucharest, Romania.
: Persistent Müllerian duct syndrome (PMDS) is a rare disorder of sex development (DSD) caused by mutations in the genes coding anti-Müllerian hormone (AMH) or the AMH receptor, characterized by the persistence of Müllerian derivatives, the uterus and/or fallopian tubes, in otherwise normally virilized boys. Testicular regression syndrome is common in PMDS, yet the association with supernumerary testis has been reported in only two patients where genetic testing was not performed. : Thus, we report an individual with this particular association caused by a previously unreported homozygous variant in the gene to enable future genotype-phenotype correlations in this rare disorder.
View Article and Find Full Text PDFDevelopment and Applications of Organoids in Gynecological Diseases.
Stem Cell Rev Rep
December 2024
Department of Obstetrics and Gynecology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Organoids are rapidly self-organizing 3D in vitro cultures derived from pluripotent stem cells (PSCs) or adult stem cells (ASCs) that possess disease-like characteristics with high success rates. Due to their ability to retain tissue structure, biological phenotypes, and genetic information, they have been utilized as a novel in vitro model for disease research. In recent years, scientists have established self-organizing 3D organoids for human endometrium, fallopian tubes, ovaries, and cervix by culturing stem cells with cytokines in 3D scaffolds.
View Article and Find Full Text PDFRecurrence Rate and Associated Factors of Primary Fallopian Tube Carcinoma in the South of Vietnam.
Gynecol Minim Invasive Ther
September 2024
Medical Student of Department of Optometry, University of Houston, USA.
Objectives: This study aimed to determine the recurrence rate and related risk factors of primary fallopian tube cancer (PFTC).
Materials And Methods: We conducted a retrospective study of 47 patients with histopathological diagnosis of PFTC treated at Tu Du Hospital between January 1, 2015, and July 31, 2022. The cumulative recurrence rate was estimated using the life table method, and recurrence-associated factors were determined using the Log-rank test and Cox proportional hazard model.
Disease management of malignant struma ovarii.
Hell J Nucl Med
December 2024
Department of Nuclear Medicine, Qiantang Branch of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Article Synopsis
- - Malignant struma ovarii (MSO) is a rare type of ovarian goiter that meets criteria for malignant thyroid tumors and can show invasive spread, with serum thyroglobulin (Tg) levels helping to differentiate it from other ovarian cancers.
- - A case study is presented involving a 54-year-old woman with abdominal pain, diagnosed post-surgery with highly differentiated follicular thyroid carcinoma originating from both ovaries, which had spread to other areas.
- - After undergoing total thyroidectomy and iodine-131 treatment, her follow-up after one year showed no significant abnormalities, highlighting the need for further discussion on clinical management and monitoring of Tg levels in MSO cases.
Analysis of real world FRα testing in ovarian, fallopian tube, and primary peritoneal cancers.
Gynecol Oncol
December 2024
Labcorp, Durham, NC, USA; Wake Forest Comprehensive Cancer Center and Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Article Synopsis
Prevalence of thyroid autoantibody positivity in women with infertility: a systematic review and meta-analysis.
BMC Womens Health
November 2024
Reproductive Medicine Research Center, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, China.
Article Synopsis
- * A meta-analysis found a global TAI prevalence of 20% in women with infertility, significantly higher than in healthy controls (risk ratio of 1.51).
- * TAI prevalence was notably higher in those undergoing assisted reproductive technology, experiencing recurrent abortions, and those with specific fertility issues like endometriosis and ovulation disorders compared to healthy individuals.
Mesenchymal stem cells: Guardians of women's health.
Regen Ther
June 2024
Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Article Synopsis
- - Mesenchymal stem cells (MSCs) are gaining interest in regenerative medicine due to their ability to differentiate into various cell types, regulate the immune system, and self-renew.
- - Recent studies have explored MSCs as potential treatments for several obstetric and gynecological conditions, such as premature ovarian failure and endometriosis, indicating their therapeutic promise.
- - The review discusses current research, challenges, and shortcomings in the clinical use of MSCs, highlighting the need for further studies to enhance their application in treating women's health issues.
Multi-locus high-risk alleles association from interleukin's genes with female infertility and certain comorbidities.
BMC Res Notes
November 2024
Department of Biology, Zand Institute of Higher Education, Shiraz, Iran.
Article Synopsis
Integrated proteomics and scRNA-seq analyses of ovarian cancer reveal molecular subtype-associated cell landscapes and immunotherapy targets.
Br J Cancer
November 2024
Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Article Synopsis
Near-infrared fluorescent molecular probes with cetuximab in the in vivo fluorescence imaging for epithelial ovarian cancer.
J Ovarian Res
November 2024
Department of Obstetrics and Gynecology, Peking University People's Hospital, No. 11 Xizhimen South Str., Xicheng District, Beijing, 100044, China.
Article Synopsis
- Near-infrared fluorescence (NIRF) imaging is effective for guiding surgery, and the study focuses on creating a tumor-specific fluorescent probe using cetuximab, which targets the EGFR prevalent in epithelial ovarian cancer (EOC).
- The research involved assessing EGFR levels in EOC using a xenograft model and employing the cetuximab-Cy7 probe for in vivo imaging, with control groups for comparison.
- Results showed high EGFR expression in EOC tissues, correlating with favorable outcomes, and confirmed that cetuximab-Cy7 effectively detected tumors, suggesting an optimal imaging window of 24-96 hours post-injection.
Study protocol of an exercise and nutrition intervention for ovarian cancer patients during and after first-line chemotherapy (BENITA) - a randomized controlled trial.
BMC Cancer
November 2024
Center for Psychosocial Medicine, Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Article Synopsis
- Ovarian cancer often leads to muscle loss, malnutrition, and fatigue, adversely affecting patients' quality of life, especially during first-line chemotherapy.
- A new study aims to assess an app-based exercise and nutrition program's effectiveness over six months compared to standard care, with physical performance measured by the 6-Minute Walk Test as the main focus.
- The study will involve a multicenter trial with a minimum of 182 participants, all diagnosed with advanced ovarian cancer, and assess various health and nutrition indicators alongside physical performance improvements.
New idea of Fuke Qianjin capsule in treating sequelae of pelvic inflammatory disease: Anti-inflammatory in the early stage and reparative in the later stage.
J Ethnopharmacol
February 2025
Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address:
Article Synopsis
- The study investigates the effectiveness of the traditional Chinese medicine Fuke Qianjin capsule (FKQ) in treating sequelae of pelvic inflammatory disease (SPID), which affects female reproductive organs and surrounding tissue.
- FKQ shows protective effects against pathogenic bacteria linked to SPID, reduces uterine damage, and minimizes inflammation by inhibiting pro-inflammatory cytokines and balancing immune cell types in a rat model.
- The research concludes that FKQ operates through a combination of antibacterial, anti-inflammatory, reparative, and immune-enhancing actions to treat SPID effectively.
Abdominal B-Cell Lymphoma Mimicking Ovarian Cancer.
Diagnostics (Basel)
October 2024
Department of Obstetrics and Gynecology, University Medical Center of Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Article Synopsis
- A 54-year-old woman presented with upper abdominal pressure, difficulty breathing, and swelling, leading to the discovery of pleural effusion, ascites, and an enlarged lymph node, suggestive of ovarian cancer.
- Upon further examination through gynecological sonography, findings confirmed ascites, an ovarian cyst, and peritoneal carcinosis, prompting a staging laparoscopy.
- Biopsies revealed a stage III B-cell lymphoma instead of ovarian cancer, and the patient began successful treatment with R-CHOP chemotherapy, showing stable health six months later.
Randomized phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer (NCT03093155): Updated survival and subgroup analyses.
BJC Rep
June 2024
Department of Pathology, Smilow Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT, USA.
Article Synopsis
- - The study investigated the effectiveness of ixabepilone (IXA) combined with bevacizumab (BEV) in treating ovarian cancers resistant to paclitaxel, revealing that the combination therapy significantly improves overall response rates (ORR) and progression-free survival (PFS) compared to ixabepilone alone.
- - A phase 2 clinical trial randomly assigned 76 patients, showing that those receiving IXA + BEV had a much higher ORR (38.4% vs. 8.1%) and greater PFS (5.5 months vs. 2.2 months) and overall survival (OS) (10.3 months vs. 6.0 months) despite many participants requiring
GATA3 expression in tumor-infiltrating mononuclear inflammatory cells is associated with poor prognostic factors in tubo-ovarian carcinomas.
Pathol Int
December 2024
Department of Pathology, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
The study investigated the expression of GATA3, a transcription factor involved in immune regulation, in tubo-ovarian carcinomas and its association with clinicopathological factors and prognosis. Immunohistochemical analysis was performed on 91 tubo-ovarian carcinoma samples to determine the presence of GATA3-positive inflammatory cells in the tumor microenvironment. A threshold of 10% or higher was considered a positive expression.
View Article and Find Full Text PDFA Case of Carcinosarcoma of the Peritoneum With Serous Tubal Intraepithelial Carcinoma.
Case Rep Obstet Gynecol
October 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, Kyorin University, Tokyo, Japan.
Article Synopsis
- - A 66-year-old woman with abdominal distention was found to have massive ascites and disseminated nodules, leading to a diagnosis of suspected Stage IIIC primary peritoneal carcinoma after imaging tests.
- - After preoperative chemotherapy, she underwent tumor reduction surgery, which revealed a primary high-grade serous carcinoma along with sarcoma and STIC in her left fallopian tube.
- - This case emphasizes the connection between peritoneal carcinoma and conditions originating from the fimbriae of the fallopian tube, contributing to understanding and potential treatments for this rare form of carcinosarcoma.
Article Synopsis
- - The NCCN Guidelines outline a comprehensive approach to diagnosing, staging, and treating ovarian, fallopian tube, and primary peritoneal cancers.
- - Recent developments in the use of PARP inhibitors, both as maintenance therapy and standalone treatments, have significantly influenced the recommendations in these guidelines.
- - These insights highlight the collaborative effort among experts to continuously update treatment protocols based on the latest research in ovarian cancer therapies.
An unusual pattern of endometrial involvement: superficial spreading squamous cell carcinoma of the cervix.
Front Oncol
October 2024
Department of Pathology, Guangyuan Central Hospital, Guangyuan, China.
Article Synopsis
- * The study reports on 15 cases of superficial spreading SCC in postmenopausal and perimenopausal women, with vaginal bleeding as a prominent symptom, all patients being HPV 16 positive.
- * Findings indicate that SCC often presents as high-grade lesions within the endometrial tissue, with varying degrees of differentiation and specific biomarkers, highlighting the complexity of this uncommon spread and the need for further management guidelines.
Vitamin D Significantly Inhibits Carcinogenesis in the Mogp-TAg Mouse Model of Fallopian Tube Ovarian Cancer.
Nutrients
September 2024
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Endeavor Health, Evanston, IL 60201, USA.
Article Synopsis
A Rare Case of Catheter Obstruction in Peritoneal Dialysis Due to Entrapment of Oviductal Fimbriae.
Cureus
September 2024
General Surgery, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, MEX.
Article Synopsis
- - Peritoneal dialysis is a treatment for end-stage chronic kidney disease, but it can have complications like infections and mechanical obstructions, which may involve organs such as the omentum and, rarely, the fallopian tube fimbriae.
- - A 65-year-old woman on peritoneal dialysis experienced abdominal pain and decreased catheter flow, leading to a CT scan that indicated a mechanical obstruction.
- - Surgery revealed that her fallopian tube fimbriae were trapped in the dialysis catheter, which was freed and repositioned; she recovered well and resumed dialysis without further complications.
Female genital schistosomiasis (FGS) in returned travellers - A review of reported cases.
Eur J Obstet Gynecol Reprod Biol
December 2024
Institute of Tropical Medicine and International Health, Charité - Universitätsmedizin Berlin, Germany. Electronic address:
Article Synopsis
- Female genital schistosomiasis (FGS) primarily affects the reproductive organs and is common in endemic areas, posing significant risks to reproductive health; travelers can also contract FGS from exposure to contaminated water in these regions.
- A review of the literature identified 38 cases of FGS in travelers, with the vulva being the most affected area, indicating that many diagnoses were incorrect initially, leading to delays in treatment.
- The study concluded that FGS in travelers shares similar characteristics with endemic cases, but the lack of timely diagnosis underscores the need for better awareness and inclusion of FGS in diagnostic protocols for returning female travelers.
The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions.
Cancer Cell
November 2024
Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA; UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA. Electronic address:
Article Synopsis
- - Most high grade serous ovarian cancers (HGSOC) start in the fallopian tube and spread, prompting the need to study immune responses at different sites of the disease.
- - Research shows that tertiary lymphoid structures (TLSs) in ovarian tumors are less developed compared to those found in fallopian tube or omental tumors, affecting immune cell activity.
- - The study highlights that normal mesenchymal stem cells (nMSCs) may enhance B cell function and TLS formation, while cancer-educated mesenchymal stem cells (CA-MSCs) hinder this process, potentially limiting the positive effects of TLS on tumor prognosis.
Prediction of non-resectability in tubo-ovarian cancer patients using Peritoneal Cancer Index - A prospective multicentric study using imaging (ISAAC study).
Gynecol Oncol
December 2024
Gynecologic Oncology Centre, Department of Gynecology, Obstetrics and Neonatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. Electronic address:
Background: The aim was to evaluate the performance of the Peritoneal Cancer Index (PCI) using imaging (ultrasound, contrast-enhanced computed tomography (CT), and whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) in assessing peritoneal carcinomatosis and predicting non-resectability in tubo-ovarian carcinoma patients.
Methods: This was a prospective multicenter observational study. We considered all patients with suspected primary ovarian/tubal/peritoneal cancer who underwent preoperative ultrasound, CT, and WB-DWI/MRI (if available).