E-Bayesian Estimation Using Spacing Function for Inverse Lindley Adaptive Type-I Progressively Censored Samples: Comparative Study with Applications.

For the first time, this paper offers the Bayesian and E-Bayesian estimation methods using the spacing function (SF) instead of the classical likelihood function. The inverse Lindley distribution, including its parameter and reliability measures, is discussed in this study through the mentioned methods, along with some other classical approaches. Six-point and six-interval estimations based on an adaptive Type-I progressively censored sample are considered.

Electrochemical Detection of 4-Nitrophenol Using a Novel SrTiO/Ag/rGO Composite.

In this study, an eco-friendly strategy was used to prepare a novel SrTiO/Ag/rGO composite. A SrTiO/Ag/rGO composite-modified screen-printed carbon electrode (SPCE) was applied for the electrochemical detection of 4-nitrophenol. A simple ultrasonic method with an ultrasonic frequency of 20 kHz was used for the synthesis of SrTiO/Ag/rGO composite material.

Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release.

The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics.

Phytochemical analysis and nephroprotective potential of Ajwa date in doxorubicin-induced nephrotoxicity rats: Biochemical and molecular docking approaches.

The purpose of this study is to evaluate the likely defensive impact of Ajwa date aqueous extract (AJDAE) in alleviating the nephrotoxicity generated by doxorubicin (DOX) injection in rats. Sixty male Wister albino rats were randomly and equally separated into six groups ( = 10), and they were treated as follows: untreated control group, extract groups administered with 0.75 and 1.

Ticks Infesting Dogs in Khyber Pakhtunkhwa, Pakistan: Detailed Epidemiological and Molecular Report.

Ticks and tick-borne diseases are considered a major challenge for human and animal health in tropical, sub-tropical, and temperate regions of the world. However, only scarce information is available on the characterization of tick species infesting dogs in Pakistan. In this study, we present a comprehensive report on the epidemiological and phylogenetic aspects of ticks infesting dogs in Pakistan using the mitochondrial markers i.

Substantial increase in P release following conversion of coastal wetlands to aquaculture ponds from altered kinetic exchange and resupply capacity.

The reclamation of wetlands and its subsequent conversion to aquaculture may alter regional nutrient (im)mobilization and cycling, although direct assessments of phosphorus (P) cycling and its budget balance following wetland conversion are currently scarce. Here, parallel field experiments were conducted to investigate and compare the availability and mobilization mechanisms of P from natural coastal wetlands and the adjacent converted aquaculture ponds based on high-resolution diffusive gradient in thin films (DGT) and dialysis (HR-Peeper) techniques and the DGT-induced fluxes in sediments (DIFS) model. The study found that the conversion of wetland to pond strongly reduced the sediment P pool by changing its forms and distribution.

Phthalate esters and plastic debris abundance in the Red Sea and Sharm Obhur and their ecological risk level.

The abundance of plastic debris (PDs) and its correlation with phthalic acid esters (PAEs), a class of pollutants associated with plastics, is not well understood, although PDs have been reported in relation to the release and distribution of aquatic pollutants such as PAEs. Few studies have linked the distribution of these pollutants in seawater. The current study examined the abundance and relationship of PDs and PAEs in seawater from Sharm Obhur and the Red Sea.

Abundant antibiotic resistance genes in rhizobiome of the human edible medicinal plant.

(or the miracle tree) is a wild plant species widely grown for its seed pods and leaves, and is used in traditional herbal medicine. The metagenomic whole genome shotgun sequencing (mWGS) approach was used to characterize antibiotic resistance genes (ARGs) of the rhizobiomes of this wild plant and surrounding bulk soil microbiomes and to figure out the chance and consequences for highly abundant ARGs, e.g.

Stability analysis of within-host SARS-CoV-2/HIV coinfection model.

The world has been suffering from the coronavirus disease 2019 (COVID-19) since late 2019. COVID-19 is caused by a virus called the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The human immunodeficiency virus (HIV) coinfection with SARS-CoV-2 has been reported in many patients around the world.

Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies.

Diabetes mellitus is a chronic metabolic disorder with increasing prevalence and long-term complications. The aim of this study was to identify α-glucosidase inhibitory compounds with potential anti-hyperglycemic activity. For this purpose, a series of new clioquinol derivatives 2a-11a was synthesized, and characterized by various spectroscopic techniques.

Transition metal catalyzed C-H bond activation by -metallacycle intermediates.

-Metallacycles have become the key reaction intermediates in activating various remote C(sp)-H and C(sp)-H bonds in the past decade and aided in achieving unusual site-selectivity. Various novel -chelating auxiliaries have assisted metals to reach desired remote C-H bonds of different alcohol and amine-derived substrates. As a result, a wide range of organic transformations of C-H bonds like halogenation, acetoxylation, amidation, sulfonylation, olefination, acylation, arylation, were accessible using the -metallacycle strategy.

High-performance ammonia-selective MFI nanosheet membranes.

Nanosheet-based MFI membranes, known to be highly selective for hydrocarbon isomer separations, exhibit an NH3/N2 mixture separation factor of 2236 with NH3 permeance of 1.1 × 10-6 mol m-2 s-1 Pa-1, and NH3/H2 separation factor of 307 with NH3 permeance of 2.3 × 10-6 mol m-2 s-1 Pa-1 at room temperature.

Mathematical modeling for novel coronavirus (COVID-19) and control.

In the present investigations, we construct a new mathematical for the transmission dynamics of corona virus (COVID-19) using the cases reported in Kingdom of Saudi Arabia for March 02 till July 31, 2020. We investigate the parameters values of the model using the least square curve fitting and the basic reproduction number is suggested for the given data is ℛ ≈ 1.2937.

Gold-Catalyzed Annulation of 1,8-Dialkynylnaphthalenes: Synthesis and Photoelectric Properties of Indenophenalene-Based Derivatives.

A simple gold-catalyzed annulation of 1,8-dialkynylnaphthalenes utilizing a cationic gold catalyst was developed. Such a peri-position of two alkynyl substituents has not been studied in gold catalysis before. Dependent on the substrate, the reactions either follow a mechanism involving vinyl cation intermediates or involve a dual gold catalysis mechanism which in an initial 6-endo-dig-cyclization generates gold(I) vinylidene intermediates that are able to insert into C-H bonds.

Caught in the Act: Variation in plastid genome inverted repeat expansion within and between populations of .

The inverted repeat (IR) lacking clade (IRLC) is a monophyletic group within the Papilionoideae subfamily of Fabaceae where plastid genomes (plastomes) do not contain the large IR typical of land plants. Recently, an IRLC legume, , was found to have regrown a ~9 kb IR that contained a number of canonical IR genes, and closely related contained an incomplete IR of ~425 bp. Complete plastomes were generated for seven additional species, putative members of the clade.

A biological mathematical model of vector-host disease with saturated treatment function and optimal control strategies.

The aims of this paper to explore the dynamics of the vector-host disease with saturated treatment function. Initially, we formulate the model by considering three different classes for human and two for the vector population. The use of the treatment function in the model and their brief analysis for the case of disease-free and endemic case are briefly shown.

Efficient Vapor-Phase Selective Hydrogenolysis of Bio-Levulinic Acid to γ-Valerolactone Using Cu Supported on Hydrotalcite Catalysts.

In this work, Cu nanoparticles (Cu NPs, 2-20 nm) supported on Hydrotalcite catalysts exhibit enhanced selectivity for γ-valerolactone (GVL) during hydrogenolysis of levulinic acid (LA). At 260 °C, over 3 wt% Cu achieved 87.5% of LA conversion with a maximum GVL selectivity (95%).

Iodine consumption and cognitive performance: Confirmation of adequate consumption.

Iodine, a dynamic nutrient present in thyroid hormones, is responsible for regulating thyroid function, supporting a healthy metabolism, and aiding growth and development. Iodine is also essential for brain development during specific time windows influencing neurogenesis, neuronal and glial cell differentiation, myelination, neuronal migration, and synaptogenesis. About 1.

Computer-aided discovery of a metal-organic framework with superior oxygen uptake.

Current advances in materials science have resulted in the rapid emergence of thousands of functional adsorbent materials in recent years. This clearly creates multiple opportunities for their potential application, but it also creates the following challenge: how does one identify the most promising structures, among the thousands of possibilities, for a particular application? Here, we present a case of computer-aided material discovery, in which we complete the full cycle from computational screening of metal-organic framework materials for oxygen storage, to identification, synthesis and measurement of oxygen adsorption in the top-ranked structure. We introduce an interactive visualization concept to analyze over 1000 unique structure-property plots in five dimensions and delimit the relationships between structural properties and oxygen adsorption performance at different pressures for 2932 already-synthesized structures.

Bioassay-guided isolation of novel and selective urease inhibitors from Diospyros lotus.

Two new dimeric naphthoquinones, 5',8'-dihydroxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (1; Di-naphthodiospyrol D) and 5',8'-dihydroxy-5,8-dimethoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (2; Di-naphthodiospyrol E), along with known naphthoquinones diospyrin (3) and 8-hydroxy diospyrin (4) were isolated from the chloroform fraction of extract of Diospyros lotus roots. Their structures were elucidated by advanced spectroscopic analyses, including HSQC, HMBC, NOESY, and J-resolved NMR experiments. The fractions and compounds 1-4 were evaluated for urease activity and phosphodiesterase-I, carbonic anhydrase-II and α-chymotrypsin enzyme inhibitory activities.

OPTIMIZATION OF ALKALINE Α-AMYLASE PRODUCTION BY THERMOPHILIC .

Background: Starch-degrading amylase enzyme is important in biotechnological applications as food, fermentation, textile, paper and pharmaceutical purposes. The aim of current study to isolate alkaline thermostable α-amylase bacteria and then study the composition of medium and culture conditions to optimize cells growth and a-amylase production.

Materials And Methods: Thermophilic amylase producing bacterium was isolated from local hot water-springs in Gazan city Saudi Arabia.

Pt-Decorated g-CN/TiO Nanotube Arrays with Enhanced Visible-Light Photocatalytic Activity for H Evolution.

Aligned TiO nanotube layers (TiNTs) grown by self-organizing anodization of a Ti-substrate in a fluoride-based electrolyte were decorated with graphitic-phase CN (g-CN) via a facile chemical vapor deposition approach. In comparison with classical TiO nanotubes (anatase), the g-CN/TiNTs show an onset of the photocurrent at 2.4 eV (vs.

Emerging Advances inNanomedicine as aNanoscalePharmacotherapy in Rheumatoid Arthritis: State of the Art.

Nanomedicines have been widely investigated for rheumatoid arthritis (RA). There are several significant setbacks including limited bioavailability, high clearance, and further current therapies require higher and frequent dosing to gain desired therapeutic effects. Though, higher doses also increase the incidence of dreadful adverse effects.