2 results match your criteria: "Faculty of Science and Technology University of Silesia[Affiliation]"
Efflux systems as a target for anti-biofilm nanoparticles: perspectives on emerging applications.
Expert Opin Ther Targets
October 2023
Institute of Chemistry, Faculty of Science and Technology University of Silesia in Katowice, Katowice, Poland.
Introduction: Understanding the role of efflux pumps in biofilm resistance provides valuable insights for developing effective therapeutic strategies. Drugs designed for targeting efflux pumps in drug design holds promise for combating biofilm-related infections. Nanoparticles offer unparalleled advantages in designing drugs targeting efflux pumps.
View Article and Find Full Text PDFEnhancement of the Physical Stability of Amorphous Sildenafil in a Binary Mixture, with either a Plasticizing or Antiplasticizing Compound.
Pharmaceutics
May 2020
Institute of Physics, Faculty of Science and Technology University of Silesia, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
Article Synopsis
- The study investigates how different polymer additives (Kollidon VA64 and poly(vinylacetate)) affect the physical stability of the amorphous drug sildenafil.
- The use of Kollidon VA64 (KVA) shows an antiplasticizing effect, slowing down molecular motion and better preventing recrystallization, while poly(vinylacetate) (PVAc) has a plasticizing effect that can destabilize the drug at low concentrations but stabilizes it at higher concentrations.
- The research highlights that KVA consistently improves the stability of amorphous sildenafil, while PVAc's impact varies significantly depending on its concentration.