Alpha-gal syndrome-Food or drug allergy: A case report.

Alpha-gal syndrome is an immunoglobulin E-mediated hypersensitivity characterized by delayed allergic reactions to ingested products containing alpha-gal carbohydrate. We present a patient with recurrent urticaria and suspected repaglinide hypersensitivity, who was eventually diagnosed with alpha-gal syndrome, wanting to emphasize possible drug allergy misdiagnosis and required caution with the medication choice.

The readiness of the spontaneous reporting system for COVID-19 vaccines safety monitoring in Croatia.

We aimed to identify whether a spontaneous reporting system (SRS) in Croatia could timely identify and confirm signals for COVID-19 vaccines. Post-marketing spontaneous reports of adverse drug reactions (ADRs) following COVID-19 immunisation reported to the Agency for Medicinal Products and Medical Devices of Croatia (HALMED) were extracted and analysed. 6624 cases reporting 30 655 ADRs following COVID-19 immunisation were received from 27 December 2020 to 31st December 2021.

The association between gene rs13212041 polymorphism and onset of alcohol abuse.

Background: Alcohol dependence displays a wide variety of clinical phenotypes. Various typology classifications of alcoholism include age of onset of alcohol abuse as one of the major phenotypic features. Serotonergic changes have been associated with alcoholism, while serotonin receptors type 1B (5-HT1B) play an important role in regulating serotonergic neurotransmission.

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents.

We report the synthesis of SAHAquines and related primaquine (PQ) derivatives. SAHAquines are novel hybrid compounds that combine moieties of suberoylanilide hydroxamic acid (SAHA), an anticancer agent with weak antiplasmodial activity, and PQ, an antimalarial drug with low antiproliferative activity. The preparation of SAHAquines is simple, cheap, and high yielding.

Antimicrobial and Antioxidant Properties of Satureja Montana L. and S. Subspicata Vis. (Lamiaceae).

Satureja montanaL. and S. subspicata Vis.

Influence of cyclodextrin complexation on piroxicam gel formulations.

The aim of this work was to evaluate the role of cyclodextrins in topical drug formulations. Solid piroxicam (PX) complexes with beta-cyclodextrin (beta-CD) and randomly methylated beta-cyclodextrin (RAMEB) were prepared by freeze-drying and characterized using differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), Fourier transform infrared spectroscopy (FTIR) and near infrared spectroscopy (NIR). A physical mixture of PX and cyclodextrins was characterized by enhanced dissolution properties compared to the dissolution profile of the pure drug due to in situ complex formation.

Mycotoxigenicity of clinical and environmental Aspergillus fumigatus and A. flavus isolates.

Clinical isolates of fifty strains of A. fumigatus and 30 strains of A. flavus from immmunocompromised patients from the hematological unit were analyzed for mycotoxin production and compared with the same number of environmental isolates (from soil, compost, and air).

Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres.

Among airborne aspergilli sampled in outdoor air of the Zagreb area (2002/2003), Aspergillus niger (v. Teigh.) and A.

Quantitative analysis of the polyphenols of the aerial parts of rock samphire--Crithmum maritimum L.

Quantitative spectrometric analyses of the contents of flavonoids, tannins and total polyphenols in the aerial parts of rock samphire--Crithmum maritimum L., collected from three separated geographic locations along the Adriatic coast of Croatia in different growth stages, are reported. The results point to variability of the analyte content as a function of the growing site and growth stage.

Effect of hydroxypropyl-beta-cyclodextrin on hydrocortisone dissolution from films intended for ocular drug delivery.

The formation of an inclusion complex between hydrocortisone and hydroxypropyl-beta-cyclodextrin can affect the in vitro transfer rate of hydrocortisone from the aqueous to the organic phase. The observed first order transfer rate constants showed that the complexation of hydrocortisone with hydroxypropyl-beta-cyclodextrin decreased significantly the transport of the drug depending on the partition coefficient of the drug, and the relative magnitude of the stability constant of the inclusion complex. To optimize the ocular drug delivery, high molecular weight cellulosis and PVA polymeric films were prepared.

Influence of the atomization time on the properties of ethylcellulose microcapsules of isoniazid prepared by a fluidized bed.

Microcapsules containing isoniazid were produced by the fluidized bed method with ethylcellulose by varying the total atomization time. The kinetics of capsules growth during the preparation was discussed on the basis of the distribution of particle size. The quality of the capsules was evaluated using the particle size characteristics, the total content of ethylcellulose, the particle and wall density, and the time needed for the 50 per cent release of the drug.

Poly(lactic acid) microencapsulated oxytetracycline: in vitro and in vivo evaluation.

Poly(lactic acid) microcapsules of oxytetracycline hydrochloride were prepared by precipitation of the polymer from a solution when a non-solvent was added to a polymer solution in which the drug had been dispersed. Three types of microcapsules were prepared by varying the amount of drug encapsulated, as well as by using two samples of polymer with different molecular weights. The product obtained was of a matrix character consisting of agglomerated capsules.