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Article Synopsis
- HMGB1 is a protein that worsens outcomes after brain ischemia, while haptoglobin (Hp) can bind to it and help mitigate its negative effects.
- In a study involving mice, administering Hp after inducing ischemia showed improvements in neurological function, motor coordination, and reduced brain damage over time.
- Hp was found to decrease HMGB1 levels and favor the M2 macrophage/microglia phenotype, suggesting it may be a promising treatment for cerebral ischemia recovery.