3 results match your criteria: "Faculty of Medicine Ludwig-Maximilians-University[Affiliation]"

Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion.

Proc Natl Acad Sci U S A

February 2023

Neuroscience Paris-Saclay Institute, CNRS UMR 9197, Paris-Sud University, Paris-Saclay University, Saclay 91400, France.

Article Synopsis
  • Oxytocin (OT) is a hormone that plays a key role in how mammals behave socially, and it is stored in special structures in the brain called LDCVs.
  • Researchers found that tiny channels in lysosomes (called TPCs) are important for releasing oxytocin by helping prepare these storage units, even if they don't directly release it right away.
  • Mice that couldn’t use TPCs showed less oxytocin and struggled with social behaviors, but giving them oxytocin helped them act normally again.
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We examined the effects of co-worker and supervisor support on job stress and presenteeism in an aging workforce. Structural equation modelling was used to evaluate data from the 2010 wave of the Health and Retirement Survey in the United States (n = 1649). The level of presenteeism was low and the level of job stress was moderate among aging US workers.

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1. Rabbit ear was single-pass perfused with protein-free buffer solution at a rate of 0.02 ml/min per cm2 surface area for up to 6 h.

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