Apalutamide-associated skin rash in patients with prostate cancer: Histological evaluation by skin biopsy.

Introduction: Apalutamide-associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding.

Case Presentation: Case 1: a 71-year-old man with metastatic castration-sensitive prostate cancer developed a skin rash after 70 days of apalutamide treatment.

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created as revised from J-SSCG 2016 jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in September 2020 and published in February 2021. An English-language version of these guidelines was created based on the contents of the original Japanese-language version. The purpose of this guideline is to assist medical staff in making appropriate decisions to improve the prognosis of patients undergoing treatment for sepsis and septic shock.

Psychogenic fever due to worry about COVID-19: A case report.

Psychogenic fever is stress-related hyperthermia that is recognized as a psychosomatic condition. We treated a 46-year-old Japanese man who was worrying about the coronavirus infection (COVID-19) and had a fever with a maximum temperature of 38.1℃.

Verification of negative pressure box for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission during upper gastrointestinal endoscopy.

During the COVID-19 pandemic era, multiple infection prevention and control measures to reduce the risk of SARS-CoV-2 transmission may be required in upper gastrointestinal endoscopy (UGI). We herein studied the verification tests of Endo barrier, which is one of the protective barrier enclosures. Endo barrier may be an alternative for minimizing SARS-CoV-2 transmission during UGI.

Premedication of hemin for eradication therapy of in patients with porphyria.

Eradication therapy of may be safe if hemin has been intravenously administered in advance, even in patients with a history of recurrent acute porphyria attack.

Rebleeding after placing over-the-scope clips: Rare complication of prophylactic closure after gastric endoscopic submucosal dissection.

Monopolar hemostatic forceps may still be able to treat for rebleeding with above mentioned challenging characteristics, and it is earning a lace in the new enodscopic hemostasis repertoire.

Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest in Adult Patients.

Extracorporeal cardiopulmonary resuscitation (ECPR) followed by targeted temperature management has been demonstrated to significantly improve the outcomes of out-of-hospital cardiac arrest (OHCA) in adult patients. Although recent narrative and systematic reviews on extracorporeal life support in the emergency department are available in the literature, they are focused on the efficacy of ECPR, and no comprehensively summarized review on ECPR for OHCA in adult patients is available. In this review, we aimed to clarify the prevalence, pathophysiology, predictors, management, and details of the complications of ECPR for OHCA, all of which have not been reviewed in previous literature, with the aim of facilitating understanding among acute care physicians.

Twelve-lead electrocardiography identifies the therapeutic target of paroxysmal supraventricular tachycardia.

Twelve-lead electrocardiography provides us the clue about the differential diagnosis between atrioventricular nodal reentrant tachycardia and atrioventricular reentrant tachycardia.

Long-term effects of low-intensity training with slow movement on motor function of elderly patients: a prospective observational study.

Background: Slow-motion training, which comprises exercising using extremely slow-movements, yields a training effect like that of high-intensity training, even when the applied load is small. We developed a slow-training exercise program that allows elderly people to safely use their own body weight without a machine. Previously, it was confirmed that functional gait and lower limb muscle strength were improved by low-intensity training using bodyweight training for 3 months.

Both Ser361 phosphorylation and the C-arrestin domain of thioredoxin interacting protein are important for cell cycle blockade at the G1/S checkpoint.

Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor that is down-regulated in several cancer tissues and tumor cell lines. Overexpression of TXNIP causes cell cycle arrest at the G1/S checkpoint in the hepatocellular carcinoma cell line HuH-7. TXNIP contains putative phosphorylation sites, but the effects of its phosphorylation have not been fully characterized.

2017 Clinical practice guidelines of the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis for the management of ANCA-associated vasculitis.

Objective: The Japan Research Committee for Intractable Vasculitis has fully revised the clinical practice guidelines (CPG) for the management of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) to improve and standardize the medical treatment of the disease in Japan.

Methods: The previous CPG was published in a classical review style in Japanese in 2011 and 2014. We adopted the Grading of Recommendations Assessment, Development and Evaluation system for this revision, and various stakeholders, including patients, participated in it.

The profile of Japanese Association for Acute Medicine - out-of-hospital cardiac arrest registry in 2014-2015.

Aim: To describe the registry design of the Japanese Association for Acute Medicine - out-of-hospital cardiac arrest (JAAM-OHCA) Registry as well as its profile on hospital information, patient and emergency medical service characteristics, and in-hospital procedures and outcomes among patients with OHCA who were transported to the participating institutions.

Methods: The special committee aiming to improve the survival after OHCA by providing evidence-based therapeutic strategies and emergency medical systems from the JAAM has launched a multicenter, prospective registry that enrolled OHCA patients who were transported to critical care medical centers or hospitals with an emergency care department. The primary outcome was a favorable neurological status 1 month after OHCA.

Effect of the volatile anesthetic agent isoflurane on lateral diffusion of cell membrane proteins.

The volatile anesthetic isoflurane (ISO) has previously been shown to increase the fluidity of artificial lipid membranes, but very few studies have used biological cell membranes. Therefore, to investigate whether ISO affects the mobility of membrane proteins, fluorescence-labeled transferrin receptor (TfR) and glycosylphosphatidylinositol (GPI)-anchored protein were expressed in human embryonic kidney 293T cells and neural cells and lateral diffusion was examined using fluorescence recovery after photobleaching. Lateral diffusion of the TfR increased with ISO treatment.

Phase I study of primary treatment with 5-FU, oxaliplatin, irinotecan, levofolinate, and panitumumab combination chemotherapy in patients with advanced/recurrent colorectal cancer involving the wild-type RAS gene: the JACCRO CC-14 study.

Background: FOLFOXIRI is now regarded as the chemotherapy regimen that offers the best platform for the treatment of colorectal cancer. However, the safety and efficacy of FOLFOXIRI + panitumumab has not been demonstrated. We conducted a phase I study to determine the recommended dose of FOLFOXIRI + panitumumab as first-line treatment for RAS wild-type metastatic colorectal cancer (mCRC).

Effects of 3 months continuous intake of supplement containing LPS to maintain normal bloodstream in adults: Parallel double-blind randomized controlled study.

In this study, the effects on the maintenance of normal bloodstream by lipopolysaccharide (LPS) were investigated in the parallel-group randomized double-blind study using supplement containing LPS (201.5 μg/tablet as LPS). Screening was previously performed in the implementation of the study.

Infective endocarditis and infected aneurysm caused by subsp. : a case report.

Endocarditis caused by subsp. (SDSE) is rare. Infected aneurysm is one of the most serious complications of infective endocarditis.

, a possible emergent organism resistant to carbapenem antimicrobials after stem cell transplantation.

A 64-year-old female was diagnosed with adult T-cell leukemia/lymphoma. She then underwent an unrelated allogeneic bone marrow transplantation with a reduced-intensity regimen. She achieved engraftment followed by HHV-6 encephalopathy.

Innovative method using circulating tumor cells for prediction of the effects of induction therapy on locally advanced non-small cell lung cancer.

Background: The existence of circulating tumor cells (CTCs) in patients with lung cancer has been reported. The purpose of this study was to assess whether CTCs are predictive of the pathological effects of induction chemoradiotherapy for patients with non-small cell lung cancer.

Methods: Patients who underwent induction chemoradiotherapy followed by surgery were compared with those who underwent surgery alone.