Bio-Mechanism Inhibitory Prediction of β-Sitosterol from Kemangi ( L.) as an Inhibitor of MurA Enzyme of Oral Bacteria: In vitro and in silico Study.

Background: Dental caries is a widespread disease that causes dental tissue destruction and leads to local and general complications. Gram-positive bacteria including , , and take part in dental caries formation. Gram-positive bacteria have cell walls that consistof a thick layer of peptidoglycan which maintains the strength and rigidity of the bacteria, as well as bacteria guard from internal osmotic pressure.