Interventions and implementation considerations for reducing pre-treatment loss to follow-up in adults with pulmonary tuberculosis: A scoping review.

Background: Tuberculosis (TB) is a leading cause of death worldwide with over 90% of reported cases occurring in low- and middle-income countries (LMICs). Pre-treatment loss to follow-up (PTLFU) is a key contributor to TB mortality and infection transmission.

Objectives: We performed a scoping review to map available evidence on interventions to reduce PTLFU in adults with pulmonary TB, identify gaps in existing knowledge, and develop a conceptual framework to guide intervention implementation.

Investigation of the Protective Effects of Dexmedetomidine, Midazolam, Propofol, and Intralipid on Oxidative Stress and Inflammation in Rats with Lidocaine-Induced Toxicity.

Aim: The aim of this study was to compare the effects of dexmedetomidine, midazolam, propofol, and intralipid on lidocaine-induced cardiotoxicity and neurotoxicity.

Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups (n = 8 per group): control (C), lidocaine (L), lidocaine + dexmedetomidine (LD), lidocaine + midazolam (LM), lidocaine + propofol (LP), and lidocaine + intralipid (LI). Dexmedetomidine (100 µg/kg), midazolam (4 mg/kg), propofol (40 mg/kg), and intralipid (10 mg/kg) were administered intraperitoneally as pretreatment.

Safety and Efficacy of Metformin for Idiopathic Intracranial Hypertension. A U.S-Based Real-World Data Retrospective Multicenter Cohort Study.

Introduction: Managing idiopathic intracranial hypertension (IIH) is challenging due to limited treatment options. This study evaluates metformin as a potential therapy for IIH, examining its impact on disease outcomes and safety.

Methods: We performed a retrospective cohort study using the TriNetX database, covering data from 2009 to August 2024.

A new parameter to increase the predictive value of multiparametric prostate magnetic resonance imaging for clinically significant prostate cancer in targeted biopsies: lesion density.

Aim: To investigate the predictive value of lesion length in multiparametric prostate magnetic resonance imaging with respect to prostate volume for clinically significant prostate cancer diagnosis in targeted biopsies.

Materials And Methods: The data of biopsy-naïve patients in the Turkish Urooncology Association Prostate Cancer Database who underwent targeted prostate biopsies were included in this study. Lesion density is calculated as the ratio of lesion length (mm) in MR to prostate volume (cc).

Critical care services in Bagmati province of Nepal: A cross sectional survey.

Background: This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a focus on access, infrastructure, human resources, and intensive care unit (ICU) services.

Methods: A cross-sectional survey was conducted among healthcare workers employed in 87 hospitals having medical/surgical ICUs across Bagmati Province. Data were collected through structured questionnaires administered via face-to-face and telephone interviews.

Current source density and functional connectivity extracted from resting-state electroencephalography as biomarkers for chronic low back pain.

Introduction: Chronic low back pain (CLBP) is a global health issue, and its nonspecific causes make treatment challenging. Understanding the neural mechanisms of CLBP should contribute to developing effective therapies.

Objectives: To compare current source density (CSD) and functional connectivity (FC) extracted from resting electroencephalography (EEG) between patients with CLBP and healthy controls and to examine the correlations between EEG indices and symptoms.

Repetitive transcranial magnetic stimulation for fibromyalgia: are we there yet?

Repetitive transcranial magnetic stimulation (rTMS) has increasingly been used to modify cortical maladaptive plastic changes shown to occur in fibromyalgia (FM) and to correlate with symptoms. Evidence for its efficacy is currently inconclusive, mainly due to heterogeneity of stimulation parameters used in trials available to date. Here, we reviewed the current evidence on the use of rTMS for FM control in the format of a narrative review, in which a systematic dissection of the different stimulation parameters would be possible.

Infant regulatory problems and the quality of dyadic emotional connection-a proof-of-concept study in a multilingual sample.

Background And Aims: Close autonomic emotional connections with others help infants reach and maintain homoeostasis. In recent years, infant regulatory problems (RPs, i.e.

Pyrazinyl-Substituted Aminoazoles as Covalent Inhibitors of Thrombin: Synthesis, Structure, and Anticoagulant Properties.

This study presents a novel series of -acylated 1,2,4-triazol-5-amines and 1-pyrazol-5-amines, featuring a pyrazin-2-yl moiety, developed as covalent inhibitors of thrombin. These compounds demonstrated potent inhibitory activity, with derivatives and achieving IC values as low as 0.7 and 0.

Digital solutions for migrant and refugee health: a framework for analysis and action.

Digital technologies can help support the health of migrants and refugees and facilitate research on their health issues. However, ethical concerns include security and confidentiality of information; informed consent; how to engage migrants in designing, implementing and researching digital tools; inequitable access to mobile devices and the internet; and access to health services for early intervention and follow-up. Digital technical solutions do not necessarily overcome problems that are political, social, or economic.

Social contact patterns and their impact on the transmission of respiratory pathogens in rural China.

Introduction: Social contact patterns significantly influence the transmission dynamics of respiratory pathogens. Previous surveys have quantified human social contact patterns, yielding heterogeneous results across different locations. However, significant gaps remain in understanding social contact patterns in rural areas of China.

A lifestyle educational course as an adjunct to biologic administration in patients with severe asthma: A feasibility study.

Objective: To assess the feasibility and acceptability of adapting a psychoeducation course (Body Reprogramming) for severe asthma and finding suggestions for improvement.

Methods: Severe asthma patients were recruited from a single centre and enrolled in an online group-based course. Each course consisted of four sessions: introduction to BR, stress, exercise, and diet.

Translation, Validity, and Reliability of the Indonesian Version of the Shoulder Pain and Disability Index (SPADI).

Background: The Shoulder Pain and Disability Index (SPADI) is a widely used 13-item shoulder-specific patient-reported outcome measure for shoulder pain disorders. The English version of SPADI is easy to use and demonstrates excellent measurement properties for clinical and research settings.

Purpose: To translate and culturally adapt an Indonesian version of SPADI (SPADI-IDN) and then validate its use in Indonesian patients.

Addressing Critical Mistakes in Administering Intravenous Medications at Omdurman Military Hospital, Khartoum, Sudan.

Objective: Errors in the preparation and administration of intravenous medications are significant contributors to morbidity and mortality rates in medical practice. Early reporting and the implementation of preventive measures can mitigate these errors. This study aims to identify patterns and frequencies of errors in IV medication preparation and administration, along with associated factors, at Omdurman Military Hospital in Khartoum, Sudan.

Utilization of mannan oligosaccharides as antibiotic substitutes in laying hens.

Among global concerns about antibiotic resistance, it is necessary to identify food-safe alternatives to enhance production. This study aimed to evaluate the impact of mannan oligosaccharides (MOS) inclusion to replace antibiotic growth promoters (AGP) in the diets of ISA Brown laying hens aged between 23 and 31 weeks. Two hundred forty hens were grouped into five treatments: Control, AGP (130 ppm of enramycin 8.

Effects of melatonin on the mitogen-activated protein kinase signaling genes in hypoxic Leydig cells.

Leydig cells play a crucial role in male reproductive physiology, and their dysfunction is often associated with male infertility. Hypoxia negatively affects the structure and function of Leydig cells. This study aimed to investigate the impact of melatonin on the c-Jun N-terminal kinase (Jnk), P38, and extra-cellular signal-regulated kinases 1 and 2 (Erk1/2) mitogen-activated protein kinase (MAPK) signaling pathways in TM3 mouse Leydig cells under hypoxia induced by cobalt (II) chloride (CoCl).

Occurrence of biofilm forming fungal species and in vitro evaluation of anti-biofilm activity of disinfectants used in drinking water.

Fungal contamination in drinking water has garnered considerable attention over the past few decades, especially considering the detrimental consequences of pathogenic fungal species on both human and animal health. The formation of biofilms by certain species is a considerable factor contributing to the emergence of severe fungal infections. This research was designed to isolate and identify fungi, particularly those capable of forming biofilms from 150 samples of drinking water sourced from various locations.

Parental use of routines, setting limits, and child screen use during COVID-19: findings from a large Canadian cohort study.

Background: An increase in child screen time has been observed throughout the COVID-19 pandemic. Home environment and parenting practices have been associated with child screen time. The purpose of this study was to examine associations between parental use of routines, limit setting, and child screen time during the (COVID-19) pandemic to inform harm-reducing strategies to limit the potential harms ensued by excessive screen use.

Psychological effects of psychedelics in adolescents.

This study aimed to investigate differences in long-term psychological effects, acute subjective effects, and side effects associated with psychedelic use in adolescents (aged 16-24), compared with adults (aged 25+). Data from two observational online survey cohorts was pooled, involving adolescents (average age 20.4 ± 2.

Cure for tantrums? Longitudinal associations between parental digital emotion regulation and children's self-regulatory skills.

Introduction: Parents often use digital devices to regulate their children's negative emotions, e.g., to stop tantrums.

Prediction of the severity of child abuse using nationwide survey data from Child Guidance Centers in Japan: focus on infancy and preschool age.

Introduction: The present study conducted a secondary data analysis of a comprehensive survey from Child Guidance Centers in Japan to identify factors that are associated with child abuse severity in infancy (0-3 years, 1,868 cases) and preschool age (4-6 years, 1,529 cases). A predictive model for abuse severity was developed.

Methods: The data originated from a nationwide survey that was conducted in April 2013, consisting of details of abuse cases, including child characteristics, abuser attributes, and family situation.

The association between the COVID-19 pandemic and interpersonal relationships among youth with a child maltreatment history.

Introduction: The COVID-19 pandemic had significant impacts on youth health and well-being. Youth with prior inequities, such as those exposed to child maltreatment, may have experienced greater psychosocial challenges and long-term difficulties than their peers, including sustained interpersonal relationships problems. Given the importance of healthy relationships during adolescence and early adulthood, the significant impact the pandemic had on youth, and the potential disproportionate challenges for youth with a child maltreatment history, the purpose of the present study was to better understand changes in relational conflict among youth with and without a child maltreatment history from the perspectives of youth themselves.

Construction of a prognostic survival model with tumor immune-related genes for breast cancer.

Background: Numerous studies have demonstrated that immune cell infiltration is a significant predictor in the prognosis of those with breast cancer. This study aimed to develop a prognostic model for undifferentiated breast cancer using immune-related markers.

Methods: Differentially expressed genes (DEGs) and prognostic factors were identified from The Cancer Genome Atlas (TCGA) database.

IRF5 as a potential immunological biomarker in lung adenocarcinoma.

Background: In the clinic, the primary conventional treatments of advanced non-small cell lung cancer (NSCLC) are surgery, radiation therapy, and chemotherapy. In recent years, immune checkpoint inhibitors (ICIs) have shown promise in optimizing therapeutic benefits when combined with other immunotherapies or standard therapies. However, effective biomarkers for distant metastasis or recurrence have yet to be identified, making it difficult to determine the best therapeutic approaches.

KIF18A and CDK1 as combined therapeutic targets in cervical and endometrial carcinomas: based on bioinformatics analysis and experiments.

Background: Chromosomal instability (CIN) has been identified as a factor that increases the susceptibility of tumor cells to kinesin family member 18A (KIF18A) inhibitors. Limited research exists on genes that are associated with sensitization to KIF18A inhibitors (KIF18Ais). Our study aimed to identify a gene linked to heightened sensitivity to KIF18Ais in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and uterine corpus endometrial carcinoma (UCEC).