The Parasite-Derived Peptide, FhHDM-1, Selectively Modulates miRNA Expression in -Cells to Prevent Apoptotic Pathways Induced by Proinflammatory Cytokines.

We have previously identified a parasite-derived peptide, FhHDM-1, that prevented the progression of diabetes in nonobese diabetic (NOD) mice. Disease prevention was mediated by the activation of the PI3K/Akt pathway to promote -cell survival and metabolism without inducing proliferation. To determine the molecular mechanisms driving the antidiabetogenic effects of FhHDM-1, miRNA:mRNA interactions and predictions of the gene networks were characterised in -cells, which were exposed to the proinflammatory cytokines that mediate -cell destruction in Type 1 diabetes (T1D), in the presence and absence of FhHDM-1.