2 results match your criteria: "Faculty of Biochemistry and Environmental Sciences and Regional Centre for Biomedical Research[Affiliation]"
Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effect of food restriction.
Nutr Neurosci
July 2022
Biochemistry Section, Faculty of Biochemistry and Environmental Sciences and Regional Centre for Biomedical Research, Universidad de Castilla-La Mancha, Toledo, Spain.
Introduction: Lipids regulate a wide range of biological processes. The mechanisms by which fatty acids (FA) and its metabolites influence the hypothalamic regulation of energy homeostasis have been highly studied. However, the effect of ageing and food restriction (FR) on this process is unknown.
View Article and Find Full Text PDFCentral s-resistin deficiency ameliorates hypothalamic inflammation and increases whole body insulin sensitivity.
Sci Rep
March 2018
Biochemistry Section, Faculty of Biochemistry and Environmental Sciences and Regional Centre for Biomedical Research, UCLM, Avda de Carlos III s/n, 45071, Toledo, Spain.
Article Synopsis
- S-resistin is a non-secretable isoform that plays a crucial role in regulating the maturation of fat cells and their inflammatory and insulin responses, yet its exact function in living organisms is not well understood.
- The study finds that reducing s-resistin levels in the hypothalamus enhances leptin and insulin signaling, decreases pro-inflammatory markers, and increases anti-inflammatory cytokines, suggesting a regulatory role in metabolism and inflammation.
- Downregulation of s-resistin not only improves insulin sensitivity but also links hypothalamic inflammation with metabolic health, particularly in aged rats, indicating its importance in the brain-fat communication pathway.