49 results match your criteria: "Faculty Hospital Hradec Kralove[Affiliation]"
Pancreatology
November 2022
Department of Surgical Science, Emergency Surgery Unit, University of Cagliari, Cagliari, Italy.
Background/objectives: Reports about the implementation of recommendations from acute pancreatitis guidelines are scant. This study aimed to evaluate, on a patient-data basis, the contemporary practice patterns of management of biliary acute pancreatitis and to compare these practices with the recommendations by the most updated guidelines.
Methods: All consecutive patients admitted to any of the 150 participating general surgery (GS), hepatopancreatobiliary surgery (HPB), internal medicine (IM) and gastroenterology (GA) departments with a diagnosis of biliary acute pancreatitis between 01/01/2019 and 31/12/2020 were included in the study.
Clin Nutr
April 2022
Department for Clinical Nutrition, University of Hohenheim, Stuttgart, Germany.
Background: Malnutrition and dehydration are widespread in older people, and obesity is an increasing problem. In clinical practice, it is often unclear which strategies are suitable and effective in counteracting these key health threats.
Aim: To provide evidence-based recommendations for clinical nutrition and hydration in older persons in order to prevent and/or treat malnutrition and dehydration.
Front Psychiatry
January 2022
Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.
Background: Negative symptoms are usually evaluated with scales based on observer ratings and up to now self-assessments have been overlooked. The aim of this paper was to validate the Self-evaluation of Negative Symptoms (SNS) in a large European sample coming from 12 countries. We wanted to demonstrate: (1) good convergent and divergent validities; (2) relationships between SNS scores and patients' functional outcome; (3) the capacity of the SNS compared to the Brief Negative Symptom Scale (BNSS) to detect negative symptoms; and (4) a five-domain construct in relation to the 5 consensus domains (social withdrawal, anhedonia, alogia, avolition, blunted affect) as the best latent structure of SNS.
View Article and Find Full Text PDFJ Thromb Thrombolysis
November 2021
Department of Neurosurgery, Charles University Medical Faculty and Faculty Hospital, Hradec Králové, Czech Republic.
Spontaneous spinal epidural hematoma (SSEH) is a very rare clinical entity with potential diagnostic difficulties and which can result in severe neurological deficit. The etiology of this rare condition is largely not known, but with potential predisposition in patients on anticoagulation medication. This includes the novel anticoagulants with direct inhibition of the factor Xa mechanism (DOACs).
View Article and Find Full Text PDFClin Nutr
May 2021
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
In evolution, genes survived that could code for metabolic pathways, promoting long term survival during famines or fasting when suffering from trauma, disease or during physiological growth. This requires utilization of substrates, already present in some form in the body. Carbohydrate stores are limited and to survive long, their utilization is restricted to survival pathways, by inhibiting glucose oxidation and glycogen synthesis.
View Article and Find Full Text PDFDiabetologia
June 2021
TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Aims/hypothesis: Women remain underrepresented in clinical trials and those with type 2 diabetes mellitus are at high risk for cardiovascular (CV) events. The sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin reduces the risk of CV death or heart failure hospitalisations in individuals with type 2 diabetes. Here, we performed a pre-specified analysis to examine whether sex modifies these effects.
View Article and Find Full Text PDFBiomed Res Int
May 2021
Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Introduction: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process.
Method: The experiment was performed on ten CHIAA. The 10% dimethylsulphoxide in 6% hydroxyethyl starch solution was used as the cryoprotectant; all CHIAA were cooled at a controlled rate and stored in the vapor phase of liquid nitrogen (-194°C).
Cent Eur J Public Health
September 2020
Department of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Objective: The two main aims of our study were to assess the quality of life (QOL) of patients with moderate or severe psoriasis treated by Goeckerman therapy and to compare QOL of our patients on the date of admission and 1 month after their discharge.
Methods: We performed a prospective study on 51 patients treated for chronic plaque psoriasis by Goeckerman regimen (GR). The psoriasis area involvement and severity was measured using the Psoriasis Area and Severity Index (PASI).
PLoS One
June 2020
Department of Cardio-Vascular Surgery, Nord Hospital and Karl Landsteiner Institute for Cardio-Vascular Research, Vienna, Austria.
Objectives And Design: At the present time there are two waiting list for patients with vascular prosthetic infection indicated for arterial transplantation in the Czech Republic. The inclusion of each patient for cold-stored or cryopreserved arterial transplantation is the preference of indicating surgeon. In this experimental work we studied the immunogenicity of rat aortal allografts treated by our new clinical cryopreservation/slow thawing protocol.
View Article and Find Full Text PDFWien Med Wochenschr
September 2020
The Fingerland Department of Pathology, Charles University Faculty of Medicine and Faculty Hospital Hradec Králové (Königgrätz), 500 05, Hradec Králové, Czech Republic.
During the entire 19th century, Czech lands (Bohemia and Moravia) were part of the Austrian Empire (from 1867, Austrian-Hungarian Monarchy). Obviously, there used to be quite frequent migration of Czechs of all social groups towards Austria, particularly to the capital Vienna. It is estimated that in the year 1900, from the 1.
View Article and Find Full Text PDFPLoS One
March 2020
Faculty Hospital Hradec Kralove, Department of Ophthalmology, Hradec Kralove, Czech Republic.
Eur Neuropsychopharmacol
August 2019
Department of Psychiatry, University of Campania "Luigi Vanvitelli", Largo Madonna delle Grazie, 80138 Naples, Italy.
Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent.
View Article and Find Full Text PDFAnticancer Res
February 2019
Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
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Blood Press
February 2019
a Internal Department II, Faculty of Medicine in Pilsen , Charles University, Prague , Czech Republic.
Aims: Unattended automated office blood pressure (uAutoOBP) has attracted more attention since SPRINT trial had been published. However, its long-term relationship to attended office blood pressure (AuscOBP) is not known.
Material And Methods: Stable treated hypertensive subjects were examined in four Czech academic hypertension centers.
PLoS One
February 2019
2nd Department of Surgery - Department of Cardiovascular Surgery, 1st Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
Objectives And Design: The aim of our study was to simulate in rats all aspects and techniques used in our new clinical program of cryopreserved alloarterial transplantation and investigate the influence of two immunosuppressive protocols with tacrolimus on acute rejection of these allografts.
Materials And Methods: Cryopreserved abdominal aortic grafts were transplanted between Brown-Norway and Lewis rats. Tacrolimus (0.
Clin Nutr
February 2019
Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
Background: Malnutrition and dehydration are widespread in older people, and obesity is an increasing problem. In clinical practice, it is often unclear which strategies are suitable and effective in counteracting these key health threats.
Aim: To provide evidence-based recommendations for clinical nutrition and hydration in older persons in order to prevent and/or treat malnutrition and dehydration.
Adv Clin Exp Med
August 2018
2nd Department of Cardiovascular Surgery, General University Hospital, Prague, Czech Republic.
Background: The aim of our experimental work was to assess the impact and morphological changes that arise during different thawing protocols on human aortic valve (AV) leaflets resected from cryopreserved aortic root allografts (CARAs).
Objectives: Two thawing protocols were tested: 1. CARAs were thawed at a room temperature (23°C); 2.
J Mol Diagn
July 2018
Department of Public Health and Primary Care, Biomedical Quality Assurance Research Unit, University of Leuven, Leuven, Belgium. Electronic address:
Molecular testing of EGFR is required to predict the response likelihood to targeted therapy in non-small cell lung cancer. Analysis of circulating tumor DNA in plasma may complement limitations of tumor tissue. This study evaluated the interlaboratory performance and reproducibility of a real-time PCR EGFR mutation test (cobas EGFR Mutation Test v2) to detect EGFR variants in plasma.
View Article and Find Full Text PDFBlood Press
October 2018
a Internal Department II, Faculty of Medicine in Pilsen , Charles University, Hradec Králové , Czech Republic.
Aims: Several papers reported that unattended automated office blood pressure (uAutoOBP) is closely related to daytime ambulatory blood pressure monitoring (ABPM). In the present study, we aim to study uAutoOBP and its relation to 24-hour ABPM and ABPM variability.
Material And Methods: Stable treated hypertensive subjects were examined in two Czech academic hypertension centres.
Nutrition
March 2018
Medical University Department, Clinic for Endocrinology, Metabolism and Clinical Nutrition, Kantonsspital Aarau, Aarau and Medical Faculty of the University of Basel, Basel, Switzerland. Electronic address:
Objectives: Refeeding syndrome (RFS) can be a life-threatening metabolic condition after nutritional replenishment if not recognized early and treated adequately. There is a lack of evidence-based treatment and monitoring algorithm for daily clinical practice. The aim of the study was to propose an expert consensus guideline for RFS for the medical inpatient (not including anorexic patients) regarding risk factors, diagnostic criteria, and preventive and therapeutic measures based on a previous systematic literature search.
View Article and Find Full Text PDFBlood Press
August 2018
a Internal Department II, Faculty of Medicine in Pilsen , Charles University, Plzen , Czech Republic.
Aims: Unattended automated office blood pressure (uAutoOBP) may eliminate white-coat effect. In the present study, we studied its relationships to attended office blood pressure (BP) and ambulatory BP monitoring (ABPM).
Material And Methods: Stable treated hypertensive subjects were examined in four Czech academic hypertension centres.
Int J Cardiol
January 2018
Harrington Heart &Vascular Institute, University Hospitals Case Medical Center, Cleveland, USA.
Aims: To assess the possible merits of optical coherence tomography (OCT) guidance in primary percutaneous coronary intervention (pPCI).
Methods And Results: 201 patients with ST-elevation myocardial infarction (STEMI) were enrolled in this study. Patients were randomized either to pPCI alone (angio-guided group, n=96) or to pPCI with OCT guidance (OCT-guided group, n=105) and also either to biolimus A9 or to everolimus-eluting stent implantation.
Molecules
July 2017
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and trimedoxime. The reactivating and neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose were evaluated. The reactivating efficacy of a newly developed oxime K305 is lower compared to the reactivating efficacy of the oxime K203 and trimedoxime while the ability of the oxime K307 to reactivate tabun-inhibited acetylcholinesterase (AChE) in the brain roughly corresponds to the reactivating efficacy of the oxime K203 and it is slightly lower compared to trimedoxime.
View Article and Find Full Text PDFPLoS One
May 2017
2nd Department of Cardiovascular Surgery, General University Hospital & 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Background: The aim of our experimental work was to assess morphological changes of arterial wall that arise during different thawing protocols of a cryopreserved human aortic root allograft (CHARA) arterial wall.
Methods: The experiment was performed on CHARAs. Two thawing protocols were tested: 1, CHARAs were thawed at a room temperature at +23°C; 2, CHARAs were placed directly into a water bath at +37°C.
Nutrition
March 2017
Medical University Department, Clinic for Endocrinology/Metabolism/Clinical Nutrition, Kantonsspital Aarau, Aarau and Medical Faculty of the University of Basel, Switzerland. Electronic address:
Objective: Although described >70 y ago, the refeeding syndrome (RFS) remains understudied with lack of standardized definition and treatment recommendations. The aim of this systematic review was to gather evidence regarding standardized definition, incidence rate and time course of occurrence, association with adverse clinical outcomes, risk factors, and therapeutic strategies to prevent or treat this condition.
Methods: We searched MEDLINE and EMBASE for interventional and observational clinical trials focusing on RFS, excluding case reports and reviews.