Factor XIII-A transglutaminase contributes to Neutrophil Extracellular Trap (NET)-mediated fibrin network formation and crosslinking.

Background: Neutrophil Extracellular Traps can contribute to thrombosis via stabilization fibrin network, which is normally conducted by plasma transglutaminase, Factor XIII-A as part of coagulation cascade. The possible presence and activity of FXIII-A in neutrophils or during NETosis is unknown. Here, we investigated potential presence of FXIII-A in neutrophils and participation in NET-fibrinogen interaction.

Influence of rainfall on physicochemical characteristics of runoff water and sediments in riverbeds affected by mining and agricultural activities.

Cartagena-La Union mining district (SE Spain) has unconnected dry riverbeds, which transport mining waste downstream under torrential rain events, polluting a coastal lagoon (Mar Menor). Additionally, in the cropland Campo de Cartagena, agricultural activities promote nitrate and phosphate accumulation in that lagoon. Therefore, this study aimed to evaluate the spatial-temporal trends of sediments and runoff water properties in El Albujón y La Carrasquilla riverbeds.

A Rare Case of Congenital Factor XIII Deficiency Secondary to Hyperconsumption: A Case Report.

Acquired Factor XIII (FXIII) deficiency is a rare condition often associated with underlying medical conditions or medications. We present a case of a 23-year-old male, who presented with prolonged bleeding from a traumatic ulcer site on his left leg. Initial laboratory investigations revealed a severe deficiency in FXIII activity (30%) and antigen levels (25%), with no evidence of congenital disorders or other underlying pathologies.

Recurrent Early Pregnancy Loss and Congenital Thrombophilia: A Prospective Study.

: This study aims to investigate the role of congenital single nucleotide thrombophilia in young females with early recurrent pregnancy loss (RPL). : We studied 120 pregnant females with RPL and 80 matched females as a control with no RPL. Females were aged ≤ 35 years, had at least two consecutive first-trimester RPLs, and the acquired cause of RPL was excluded.

A case of autoimmune factor XIII deficiency due to clearance-accelerating and inhibitory anti-FXIII autoantibodies.

A 63-year-old man, previously diagnosed with multiple autoimmune diseases, developed life-threatening bleeding after gastrectomy for stomach cancer. He survived due to treatment with factor XIII (FXIII) concentrates immediately after his FXIII antigen (Ag) level was reported to be < 5% of normal. Detailed examination by the Japanese Collaborative Research Group on autoimmune coagulation factor deficiencies revealed the presence of anti-FXIII-A and anti-FXIII-B subunit autoantibodies on immunoblot analyses, and thus autoimmune FXIII deficiency (AiF13D) was diagnosed based on the Japanese and international diagnostic criteria.

Cross-cultural adaptation and validation of the Spanish version of the Cardiopulmonary Resuscitation Motivation Scale (s-CPRMS): a cross sectional study.

Background: Cardiac arrest remains a serious global health issue worldwide which claims for review and improvement. High motivation among resuscitators could lead to high-quality resuscitation and better outcomes. This study aimed to translate and cross-culturally adapt the Cardiopulmonary Resuscitation Motivation Scale into Spanish and assess the psychometric properties of the Spanish version (s-CPRMS).

Expression Levels of PF4, ALOX12, ITGA2B, F131A in Pregnant COVID-19 Survivors.

COVID-19 is viral illness caused by SARS-CoV-2. The immediate complications of COVID-19 are well defined and associated with increased mortality. A global effort is required to determine its effects on implantation, fetal growth and labor.

Dengue virus NS1 leads to downregulation of HNF4 alpha in liver cells resulting in a decrease in coagulation factors I, V, X, and XIII, contributing to coagulopathy.

Unlabelled: Dengue virus NS1 protein is a major pathogenic protein. In this study, we examined the role of NS1 in coagulopathy associated with Dengue infection, a common feature of Dengue virus pathogenesis. Since most coagulation factors are produced by hepatocytes and liver is key organ affected during infection, we conducted transcriptomics using total-RNA extracted from Huh7 cells overexpressing NS1 protein.

Correlation of factor XIII subunit A with factor XIII activity in a population of parturient women.

Background: The role of factor XIII in acute bleeding situations is gaining more and more importance. It has previously been shown that prepartum factor XIII activity has a significant impact on postpartum blood loss. Whether factor XIII antigen behaves in a similar manner is unknown.

Assessment of Genetic Variants Linked to Susceptibility to Mechanical Prosthetic Valve Thrombosis.

Prosthetic valve thrombosis (PVT) is a critical and life-threatening condition driven by multifactorial etiologies, including genetic predispositions. The study was designed as a single-center retrospective manner. Echocardiographic features and genetic test including factor II/prothrombin (G20210A), factor V Leiden (G1691A), factor V R2 (A4070G), apolipoprotein (Apo) B-100 (G10708A), ApoE (C112R), ApoE (R158C), methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, factor XIII G103T (V34L), β-fibrinogen (455G>A), PAI-1 4G/5G, and HPA-1 GPIIIa (T196C) genotyping variations were assessed.

Cryo-EM structure of the human native plasma coagulation factor XIII complex.

The structure of human coagulation factor XIII (FXIII), a heterotetrameric plasma pro-transglutaminase that covalently crosslinks pre-formed fibrin polymers, remains elusive until today. The heterotetrameric complex is composed of two catalytic FXIII-A and two protective FXIII-B subunits. Structural etiology underlying FXIII deficiency has so far been derived from crystallographic structures, all of which are currently available for the FXIII-A2 homodimer only.

Acquired Low Factor XIII Activity Is Associated with an Increased Need for Blood Transfusions in Patients with Gastrointestinal Bleedings.

Background: Factor XIII plays a key role within the coagulation cascade.

Objective: We aimed to investigate the relevance of factor XIII activity on the outcome of patients with gastrointestinal bleedings.

Methods: In this retrospective, single-center study patients with gastrointestinal bleeding and measurement of factor XIII activity were included.

Can prothrombotic gene variants and Apoa1 rs5069 polymorphism be the predictors of early myocardial infarctions?

Background/aim: We aimed to determine the genetic risk factors in patients aged 45 years and below with a history of early myocardial infarction (MI), compared to individuals over 60 years of age with no history of MI.

Materials And Methods: In this study, we selected different age groups to more clearly distinguish genetic differences. Accordingly, we compared individuals who had experienced MI at an early age with those who were older and had not experienced any cardiovascular events.