11,109 results match your criteria: "Factor V"
Best Pract Res Clin Gastroenterol
December 2024
Aster Integrated Liver Care, Aster Medcity, Kochi, India.
Acute liver failure (ALF) is a rare and dynamic syndrome occurring as a sequela of severe acute liver injury (ALI). Its mortality ranges from 50% to 75% based on the aetiology, patients age and severity of encephalopathy at admission. With improvement in intensive care techniques, transplant-free survival in ALF has improved over time.
View Article and Find Full Text PDFDiabetologia
December 2024
Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China.
Aims/hypothesis: The key pancreatic beta cell transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MafA) is critical for the maintenance of mature beta cell function and phenotype. The expression levels and/or activities of MafA are reduced when beta cells are chronically exposed to diabetogenic stress, such as hyperglycaemia (i.e.
View Article and Find Full Text PDFRetin Cases Brief Rep
December 2024
Liverpool Ocular Oncology Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
Purpose: The Foldable Capsular Vitreous Bag (FCVB) implant is useful in maintaining ocular structure in cases of chronic hypotony secondary to trauma or repeated surgery. There are few published reports of long-term outcomes and no indication of the chronic cellular changes of the adjacent tissues associated with FCVB implantation. We describe one of few FCVB cases in the UK and present histological findings associated with it following secondary enucleation.
View Article and Find Full Text PDFJ Thromb Haemost
November 2024
Department of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm University, Solna, Sweden.
Background: In the splice variant factor (F)V-Short, 702 residues are deleted from the B domain, resulting in exposure of an acid region (AR2; 1493-1537) that binds TFPIα. FV-Short and protein S serve as synergistic TFPIα cofactors in inhibition of FXa. In the preAR2 region, a hydrophobic patch PLVIVGL (1481-1487) is crucial for synergistic TFPIα-cofactor activity and assembly of FV-Short, TFPIα, and protein S.
View Article and Find Full Text PDFWorld J Hepatol
November 2024
Department of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva 1205, Switzerland.
J Clin Med
November 2024
Thrombosis Hemostasis Laboratory, School of Medicine, The University of Jordan, Amman 11942, Jordan.
: This study aims to investigate the role of congenital single nucleotide thrombophilia in young females with early recurrent pregnancy loss (RPL). : We studied 120 pregnant females with RPL and 80 matched females as a control with no RPL. Females were aged ≤ 35 years, had at least two consecutive first-trimester RPLs, and the acquired cause of RPL was excluded.
View Article and Find Full Text PDFThromb Res
November 2024
Department of Pediatric Oncology and Hematology, Univ Montpellier, CHU Montpellier, Montpellier, France; Resources and Competence Center for Constitutional Bleeding Disorders, Univ Montpellier, CHU Montpellier, Montpellier, France; IRMB, University of Montpellier, INSERM, Montpellier, France. Electronic address:
Cureus
October 2024
Internal Medicine, County Emergency Clinical Hospital of Targu Mures, Targu Mures, ROU.
Although thrombotic events are uncommon in young individuals, patients with genetic mutations in coagulation factors may develop extensive multisite thrombosis. We present the case of a 26-year-old patient, a smoker for nine years, who was admitted to the hospital complaining of right thigh pain with swelling, right flank abdominal pain, dyspnea, and hemoptysis. A medical history provided by the patient indicated that one month prior to presentation, an accidental fall had resulted in multiple rib fractures, bilateral hemopneumothorax, and pneumomediastinum.
View Article and Find Full Text PDFMed Sci (Basel)
November 2024
Dietetetics and Biomedical Department, School of Health Sciences Aegean College, 45 Tsimiski Str., 54623 Thessaloniki, Greece.
Res Pract Thromb Haemost
October 2024
Haemophilia Centre for Children and Adolescents/Haemostasis and Thrombosis Unit, "Aghia Sofia" Children's Hospital, Athens, Greece.
Background: Adenoviral vector COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) is a heparin-independent platelet-activating disorder. An increasing number of VITT-like disorders without previous vaccination are being identified.
Key Clinical Question: To explore the association of the pediatric cluster of postinfectious thrombosis and thrombocytopenia with VITT-like disorders.
Medicine (Baltimore)
November 2024
Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu, People's Republic of China.
BMJ Case Rep
November 2024
UCLA Medical Center Olive View, Sylmar, California, USA.
Autoimmunity
December 2024
Tongde Hospital of Zhejiang Province, Pulmonary and Critical Care Medicine, Hangzhou, Zhejiang, China.
Asthma poses a major threat to human health. The aim of this study was to identify genetic markers of severe asthma and analyze the relationship between key genes and immune infiltration. Differentially expressed genes (DEGs) were first screened by downloading the training set GSE69683 and validation set GSE137268 from the GEO dataset.
View Article and Find Full Text PDFNurs Open
November 2024
Department of Nursing, Youngsan University, Yangsan, Republic of Korea.
Aims: To investigate public perceptions of telenursing in South Korea, an Asian country that is transitioning to the introduction of telenursing and possesses a high level of information and communication technology. This study sought to uncover strategies for the successful introduction and extension of telenursing by identifying the characteristics of existing perceptions.
Design: Q methodology was applied.
Arterioscler Thromb Vasc Biol
December 2024
Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.).
BMC Pregnancy Childbirth
November 2024
Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey.
Objective: Thrombophilia screening has been performed in patients with conditions such as previous fetal death, (fetal growth restriction) FGR, preeclampsia, (hemolysis. elevated liver enzyme, low platelet count) HELLP Syndrome, previous abruptio placentae, previous thrombosis in pregnancy, and abnormal placental histology. The actual role of hereditary thrombophilia in recurrent pregnancy loss (RPL) is still debated.
View Article and Find Full Text PDFCell Signal
January 2025
Department of Gastrointestinal surgery, Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying 257091, Shandong, China. Electronic address:
Objective: Gastric cancer is malignant cancer with high morbidity and mortality worldwide. Milk fat globule EGF and factor V/VIII domain containing (MFGE8) was involved in many cancers. Nevertheless, the role of MFGE8 in gastric cancer remained indistinct.
View Article and Find Full Text PDFNewborn (Clarksville)
March 2024
Global Newborn Society, Clarksville Maryland, United States of America.
Am J Cardiol
January 2025
Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital, Istanbul, Türkiye; Division of Health Sciences, Ardahan University, Ardahan, Türkiye.
Prosthetic valve thrombosis (PVT) is a critical and life-threatening condition driven by multifactorial etiologies, including genetic predispositions. The study was designed as a single-center retrospective manner. Echocardiographic features and genetic test including factor II/prothrombin (G20210A), factor V Leiden (G1691A), factor V R2 (A4070G), apolipoprotein (Apo) B-100 (G10708A), ApoE (C112R), ApoE (R158C), methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, factor XIII G103T (V34L), β-fibrinogen (455G>A), PAI-1 4G/5G, and HPA-1 GPIIIa (T196C) genotyping variations were assessed.
View Article and Find Full Text PDFToxins (Basel)
October 2024
Adaptive Biotoxicology Lab, School of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.
Pathophysiology
October 2024
Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
Thrombophilia, a predisposition to develop blood clots, is very common and can have serious sequelae. This study aimed to determine the prevalence of three thrombophilia-related genetic variants-factor V Leiden (FVL), prothrombin (F2) G20210A, and MTHFR C677T-in the Qatari population and their associations with self-reported thrombosis. We analysed samples from 408 Qatari participants [304 controls and 104 with self-reported thrombosis (deep vein thrombosis, pulmonary embolus, or ischaemic stroke)] from the Qatar Biobank.
View Article and Find Full Text PDFRes Pract Thromb Haemost
October 2024
Department of Mathematics and Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA.
Background: In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation.
Objectives: To assess the impact of protein level variations on simulated thrombin generation in normal and factor (F)VIII-, FIX-, or FXI-deficient blood.
J Med Case Rep
October 2024
Consultant anaesthetists, Leicester Royal Infirmary, Leicester, UK.
Background: This is an interesting and unexpected thromboembolic event in a hemophiliac patient.
Case Presentation: This is a case of a 33-year-old primigravidarum of Indian Asian origin with Factor V and Factor VIII deficiency who developed a case of pulmonary embolism during the course of her pregnancy after presenting to the emergency department in Leicester, United Kingdom, with hemoptysis, tachycardia, and tachypnea. Patient was subsequently diagnosed with pulmonary embolism after a computed tomography pulmonary angiogram and was treated with therapeutic daltaparin, a low-molecular-weight heparin.
J Am Heart Assoc
November 2024
INSERM, Bordeaux Population Health Research Center, UMR 1219, ELEANOR, University of Bordeaux Bordeaux France.
Front Microbiol
October 2024
Department of Chemistry, Umeå University, Umeå, Sweden.
Pathogenic serotypes of , transmitted through contaminated water and food, are responsible for outbreaks of cholera, an acute diarrheal disease. While the cholera toxin is the primary virulence factor, also expresses other virulence factors, such as the tripartite toxin MakABE that is secreted via the bacterial flagellum. These three proteins are co-expressed with two accessory proteins, MakC and MakD, whose functions remain unknown.
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