Patient's Perception of Primary Health Care Provision With Respect to Access, Continuity and Coordination-InCept: An International Qualitative Perspective.

Health care systems are confronted with an increasing burden of (multi-)morbidity and a shortfall of healthcare providers. Coordination and continuity of care in chronic and multi-morbid patient is especially important. As qualitative patient experience data within care processes is scarce, we aim to increase the understanding of chronically ill patient's perspectives by assessing patient experiences in different health systems while treated in primary care.

Fibrinolytic enzyme fromArthrospira platensisand its effects on breast cancer cells: Exploring its potential as an innovative therapy.

Fibrinolytic enzymes are promising in treating cardiovascular diseases due to their capacity to dissolve blood clots. The fibrinolytic enzyme from Arthrospira platensis (FEAP) was purified by ion exchange chromatography to investigate its ability to activate plasminogen, as well as its thrombolytic and fibrinogenolytic potential. Subsequently, two different cytotoxic assays (MTT and NR) and hemolysis test were performed to evaluate FEAP's safety.

Malnutrition/exercise interaction in the rat mother-pup dyad: a behavioral and electrophysiological analysis.

Objectives: Maternal protein malnutrition alters brain functioning, impairing fetal development. Physical exercise during gestation benefits the fetal organism from maternal adaptive changes that may be neuroprotective. This study evaluated the effect of a low-protein diet associated with maternal voluntary physical activity (VPA) on rats' behavioral and brain electrophysiological parameters in the mother-pup dyad.

Combining digital imaging and quantum dots for analytical purposes.

This review provides a critical assessment of the most recent advances in digital imaging (DI) methods, applied for the development of analytical methodologies combining quantum dots (QDs). The state-of-the-art, treatment of data, instrumental considerations, software, sensing approaches, and optimization of the resulting methods are reported. Applications of the technology for the analysis of food and beverages, biomedically relevant analytes, drugs, environmental samples and forensic samples are also discussed.

Influence of the addition of gum arabic and xanthan gum in the preparation of sodium alginate microcapsules coated with chitosan hydrochloride on the survival of Lacticaseibacillus rhamnosus GG.

The microencapsulation of Lactocaseibacillus rhamnosus GG in a matrix of sodium alginate, xanthan gum, gum arabic and chitosan hydrochloride is a promising strategy for protecting this probiotic during passage through the gastrointestinal tract. This study evaluated the influence on the viability of Lactocaseibacillus rhamnosus GG encapsulated with these polymers by external ionic gelation with vibratory extrusion and the microcapsules that showed the best results of capsulation efficiency, viability, size and morphology were analyzed by Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA) and exposure to environmental stress conditions and gastrointestinal simulation. The result revealed encapsulation efficiency values above 95 % for all formulations and survival rate higher than 6 log CFU/mL for most analyzed groups.

New series of 3-pyridyl-1,3-thiazoles: In vitro and in vivo anti-Trypanosomatidae profile, in vitro and in silico mechanism of action approach.

Trypanosomatidae diseases, such as Chagas disease and leishmaniasis, are caused by protozoan parasites of the Trypanosomatidae family, namely Trypanosoma cruzi and Leishmania species, respectively. There is an urgent need for new therapies. Both pyridine and thiazole rings are recognized as important scaffolds in medicinal chemistry.

Preoperative CT-Scan Angiography Reconstruction Before Right Colectomy with Complete Mesocolon Excision: A Systematic Review and Meta-analysis.

Background: Complete mesocolon excision (CME) and central vascular ligation for right colonic cancers have been developed to improve oncological outcomes. However, it has been linked with a higher risk of morbidity and technical difficulties in operating near major vessels. This study investigated the impact of preoperative surgical planning utilizing CT reconstruction on surgical outcomes in right colectomy with CME.

Hydrological modeling applied to water synergy evaluation in Castanhão Reservoir, Ceará, Brazil.

Arid and semiarid regions have particularities that make more difficult hydrological modeling, such as shallow soils, pronounced temporal and spatial irregularity of precipitation, and sometimes, lack of consistent data. In order to contribute to the hydrological studies in these regions, this research used the CAWM IV model (Campus Agreste Watershed Model Version IV), specially developed for applications in these areas. This model was used to simulate the input of natural flows in the Castanhão reservoir, the most important reservoir in the state of Ceará, northeast of Brazil.

Impact of body composition and muscle health phenotypes on survival outcomes in colorectal cancer: a multicenter cohort.

Body composition abnormalities are prognostic markers in several types of cancer, including colorectal cancer (CRC). Using our data distribution on body composition assessments and classifications could improve clinical evaluations and support population-specific opportune interventions. This study aimed to evaluate the distribution of body composition from computed tomography and assess the associations with overall survival among patients with CRC.

The endocannabinoid system's genetic polymorphisms in sickle cell anemia patients.

Sickle cell anemia (SCA) is a monogenic blood disease with complex and multifactorial pathophysiology. The endocannabinoid system (ECS) could be a candidate for modulating SCA complications, such as priapism, as it has demonstrated an essential role in hematopoiesis, platelet aggregation, and immune responses. We evaluated the association of ECS-related single nucleotide polymorphisms (SNP) (FAAH rs324420, MAGL rs604300, CNR1 rs7766029, and CNR2 rs35761398) with priapism in a Brazilian SCA cohort.

The Influence of Fluoxetine on the Sensorimotor Function of the Sciatic Nerve in Wistar Rats after Axonotmesis: An Experimental Animal Model.

Background: Fluoxetine, a serotonin reuptake inhibitor antidepressant, raises extracellular serotonin levels and promotes angiogenesis and neurogenesis. Numerous animal models have shown its beneficial effects on recovery from peripheral nerve injury.

Purpose: The primary objective of this study was to analyze the influence of fluoxetine on the sensory-motor function recovery of the sciatic nerve in Wistar rats after axonotmesis.

Bactericidal Metal-Organic Gallium Frameworks - Synthesis to Application.

Gallium, a trace metal not found in its elemental form in nature, has garnered significant interest as a biocide, given its ability to interfere with iron metabolism in bacteria. Consequently, several gallium compounds have been developed and studied for their antimicrobial properties but face challenges of poor solubility and formulation for delivery. Organizing the metal into three-dimensional, hybrid scaffolds, termed metal-organic frameworks (MOFs), is an emerging platform with potential to address many of these limitations.

Single-Leg Balance and Lower Limb Strength: Quantitative Analysis with the Balance Master System.

: This study investigates the relationship between lower limb strength and postural stability in single-leg stance using the Balance Master system. : The research involved 64 participants divided into sedentary and physically active groups based on metabolic equivalents of task (METs) values, normal weight, overweight, and obese according to body composition. Postural control was evaluated using the Sensory Organization Test.

Exploring the effects of climate change on child malnutrition: protocol for a scoping review.

Introduction: Rapid climate changes in the early 21st century have triggered a global syndemic intertwining obesity, undernutrition and climate change, profoundly affecting health, especially children. Despite increasing research, a significant gap persists in understanding the mechanisms linking climate change to child malnutrition, particularly in children under 5 years old. This protocol proposes a scoping review to address this gap, with the aim of mapping the available evidence on the relationship between climate change and malnutrition among children under 5 years old.

Synthesis of Silver Nanoparticles and Evaluation of Antimicrobial Activity Using the Aqueous Extract of Pterodon emarginatus Seeds.

The decline in research for new antimicrobials, combined with the rise in bacterial resistance, has become a critical issue that is expected to worsen over time. As an alternative, health sciences have integrated materials engineering to develop new bioactive compounds through the interaction of nanoparticles with plant-derived compounds. These compounds offer advantages such as high bioavailability and low cost, exemplified by , a plant native to the Brazilian Cerrado.

Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches.

Thiadiazines are heterocyclic compounds known for some pharmacological activities. However, the ability of these compounds and their derivatives to act as antibacterial agents and inhibitors of the efflux system in resistant bacteria remains unknown. This study aims to evaluate the antibacterial and NorA efflux pump inhibitory activities of thiadiazine-derived compounds (IJ14, IJ15, IJ16, IJ17, IJ18, IJ19, and IJ20) against the Staphylococcus aureus 1199B strain.

Repeat competition and ecological shifts drive the evolution of the mobilome in Rhynchospora Vahl. (Cyperaceae), the holocentric beaksedges.

Background And Aims: Genomic changes triggered by polyploidy, chromosomal rearrangements, and/ or environmental stress are among factors that affect the activity of mobile elements, particularly Long Terminal Repeats Retrotransposons (LTR-RTs) and DNA transposons. Because these elements can proliferate and move throughout host genomes, altering the genetic, epigenetic and nucleotypic landscape, they have been recognized as a relevant evolutionary force. Beaksedges (Rhynchospora) stand out for their wide cosmopolitan distribution, high diversity (~400 spp.

The effect of telehealth on clinical outcomes in patients with hypertension and diabetes: A meta-analysis of 106,261 patients.

Introduction: Telemedicine, propelled by recent technological advancements, has transformed healthcare delivery, notably benefiting patients with chronic non-communicable diseases (NCDs) such as systemic arterial hypertension and diabetes mellitus. This meta-analysis of randomized clinical trials aimed to assess the efficacy of telehealth-based interventions on disease control rates and clinical parameters among NCD patients, including systolic and diastolic blood pressure (SBP and DBP), fasting blood glucose (FBG), and glycated hemoglobin (HbA1c) levels.

Methods: We conducted searches in PubMed, Scopus, Web of Science, and the Cochrane Database for interventional studies that compared tele-monitoring with usual care in patients with hypertension and type 2 diabetes mellitus.

Earlier diagnosis of peripheral neuropathy in primary care in Latin America using a simple screening tool (ACT).

Peripheral Neuropathy (PN) can significantly impair quality of life, but often remains undiagnosed due to limited clinic time, lack of specialist expertise and lack of patient awareness. There are several validated questionnaires for diagnosing PN, but the time taken to administer them in busy primary care clinics limits their utilization. A new, simpler questionnaire was developed following an advisory board meeting in Southeast Asia and was further refined and translated to Portuguese and Spanish following a second advisory board meeting in Latin America.

Lectin from microalgae: Non-toxic to human cells and effective against Leishmania.

New leishmanicidal products are needed for the treatment to be effective, since current drugs are toxic to healthy human/animal cells and have low efficacy against the parasite. Bioactive compounds from microalgae, such as lectins, can be explored as new anti-Leishmania candidates. This study aimed to evaluate the cytotoxic and anti-Leishmania action of the cell extract (CE) and lectin (CVU) from Chlorella vulgaris biomass.

Efficacy of caffeine as an ergogenic aid in multiple cycling time trials.

Introduction: Evidence that caffeine supplementation is effective to improve performance in cycling time trials has been obtained in single rather than multiple time trials. We investigated whether 5 mg.kg of caffeine enhanced performance in multiple 4 km cycling time trials (TT4km) conducted within the same day and across different days.

Artificial Neural Network-Assisted Facial Analysis for Planning of Orthognathic Surgery.

Background: Facial analysis for orthognathic surgery aims to identify facial features and determine how occlusion should be corrected to achieve facial balance. Several artificial neural networks have been developed to detect facial landmarks; however, no publications have reported the application of neural networks to measure facial proportions specifically for orthognathic surgery planning. Objectives: To develop a computer program that automates facial measurements through photograph capture, as well as to present the development stages of the program and the test results evaluating its effectiveness.